Protein Alignment GluRIA and Ir60a

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_611901.1
• Gene: Ir60a / 37881
• FlyBaseID: FBgn0034994
• Length: 716
• Species: Drosophila melanogaster
• Alignment Length: 735
• Identity: 128/735 - (17%)
• Similarity: 248/735 - (33%)
• Gaps: 217/735 - (29%)

  Fly   341 EAFNRILRK------KPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEK 399
            |.|::::.:      .||  |....|.|.  .|..:...||.:...|:   .:..:|...:..::
  Fly    95 EGFSKLINEAVTNPGPPD--REELFQMRV--ASDYNITNGTEDKGELI---LADNYVIVVDSVDR 152

  Fly   400 ISRVLRK--VEIDGLSGEIRF--------------------DEDGRRINYTLHVVEMSVNSTL-- 440
            :..:::|  ||:...:...||                    .:|...:.|...|..:..|||:
  Fly   153 LKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPLGVASNIFKDLMEMFYVHRVALLYANSTMNY 217

  Fly   441 ------------------QQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLE 487
                              |.|.:..|.    .|:.:|....:......:|...||.|:...|.:.
  Fly   218 NLLVNDYYSNVNCRILNVQSVGQCHDG----KLYPNNAVVKASMQDYVSGFSPRNCTFFACSSIS 278

  Fly   488 EPYLSLKQYTYGESLVGND-RFEGYCKDLADMLAAQLGIKYEI--------RLVQDGNYGAENQY 543
            .|::.      .:.::|.: |..|:.|:         .:|:::        |...||
  Fly   279 APFVE------ADCILGLEMRILGFMKN---------RLKFDVNQTCSLESRGEMDG-------- 320

  Fly   544 APGGWDGMVGELIRKEADIAISAMTITAERERVID-------FSKPFMTLGISIMIKKPVKQT-P 600
             |..|.|::|::...|.|..........|   |.|       :.:...|..|.:..::|..|. .
  Fly   321 -PANWTGLLGKVQNNECDFVFGGYYPDNE---VADHFWGSDTYLQDAHTWYIKMADRRPAWQALV 381

  Fly   601 GVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSE 665
            |:|....      ||..||..: :|::.:|....                           .|.|
  Fly   382 GIFEAYT------WIGFILILI-ISWLFWFTLVM---------------------------ILPE 412

  Fly   666 PQAHVPPVPPNEFTMLNSFWYSLAAFMQQG--CDITPPSIAGRIAAAVWWFFTIILISSYTANLA 728
            |:.:    .....|.:|:...:::..:|:.  |:.|      |:      ||  :.::.|..|:.
  Fly   413 PKYY----QQLSLTAINALAVTISIAVQERPICETT------RL------FF--MALTLYGLNVV 459

  Fly   729 AFLTVERMVAPIKTP---EDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVH 790
            |..| .:|:|..:.|   ..|...|:|....:.:|...|  .|......:.||.:         :
  Fly   460 ATYT-SKMIATFQDPGYLHQLDELTEVVAAGIPFGGHEE--SRDWFENDDDMWIF---------N 512

  Fly   791 TYDEGIRRVRQSK-------GKYALL------VESPKNEYVNARPPCDTMKVGRNIDTKGFGVAT 842
            .|:.....:.|||       |:..:|      ::||..:.:.|.|        .|:.:....:..
  Fly   513 GYNISPEFIPQSKNLEAVKWGQRCILSNRMYTMQSPLADVIYAFP--------NNVFSSPVQMIM 569

  Fly   843 PIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECN-----LDQETSTPNELSLSNVAGIYYI 902
            ..|.|....:|..:..:::.|...:|...:.::.|..|     ..|...|...|:..::.|.::|
  Fly   570 KAGFPFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPETAIVLTTEHLKGPFFI 634

  Fly   903 LIGGLLLAVIVAIMEFFCRNKTPQLKSPGSNGSAGGVPGMLASSTYQRDSLSDAIMHSQAKLAMQ 967
            |:.|...|.:..|.|........|                |.|::.|:|..||.....:.:...:
  Fly   635 LVVGSCWAALTFIGELIIHRWRTQ----------------LVSTSEQQDRRSDKRRRRRRRRKPE 683

  Fly   968 ASSEYDERLVGVELASNVRY 987
            ..:.:..:   |::|..||:
  Fly   684 KDNRWQRQ---VQVAPVVRF 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	26/162 (16%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	76/436 (17%)
		Lig_chan	610..906	CDD:459656	56/318 (18%)
Ir60a	NP_611901.1	None