DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and gria3b

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	893	Identity:	373/893 - (41%)
Similarity:	531/893 - (59%)	Gaps:	83/893 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KIPLGAIFEQGTDDVQSAFKYA--MLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRG 101
            :|.:|.:|.:.|....|||::|  :.|.|.|::.:.|.|...||.:.::::|.::...|:|||||
Zfish    23 QINIGGLFMRSTVQEHSAFRFAVQLYNTNQNMTEKPFHLNYNVDNLESSNSFSVTHAFCSQFSRG 87

  Fly   102 VYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYY 166
            ||::.|.....|.:||.|:.......||||.:      |....:.|.|.|||....|::..:.:|
Zfish    88 VYAIFGFYDKKSMNTLTSFCGALHTSFVTPSY------PIDSDVQFVIQMRPPLKGAVLSLLSHY 146

  Fly   167 GWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIV 231
            .|...:||||:..|...||.|.:.....|  ::| ..:.:.::|...||...:|::.|..:||.:
Zfish   147 KWDKFVYLYDTDRGFSILQAIMEAAVANN--WQV-TARSVGSITDPQEFRRIIEEMDRRQEKRYL 208

  Fly   232 LDCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRA 294
            :||..:....|:.|.|   .||:  |.|||:::.|...| ...|.|..|..||:||:|::.....
Zfish   209 IDCEVDRINVILEQVV---TLGKNSRGYHYIIANLGFTN-ISLDKVFLGGANISGFQIINPENLV 269

  Fly   295 VRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHL 359
            |:.|.....||:.....:::|.       .:...:||.|||:.|:.|||..:.|::.|      :
Zfish   270 VQQFLQRWDRLDEREFPEAKNT-------PLKYTSALSYDAILVIAEAFRYLRRQRVD------V 321

  Fly   360 QRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRR 424
            .||...|                ||..:.  ..||.||..|.|.|:.|::.|::|.|:||..|||
Zfish   322 SRRGSAG----------------DCLANP--AVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRR 368

  Fly   425 INYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEP 489
            .|||:.|.||..... :::..|.:....:.:....:.:.|.|.        .|.|.:|::::|.|
Zfish   369 TNYTIDVYEMKTGGP-RKIGYWNEFERFVNIMDQQFTNDSSSV--------ENRTIVVTTIMEAP 424

  Fly   490 YLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGE 554
            |:..|:...  .|.||:::||||.|||..:|..:||||.:.:|.||.|||.:.... .|:|||||
Zfish   425 YVMYKKNHM--HLEGNEKYEGYCVDLASEIAKHVGIKYRLSIVMDGKYGARDPETK-SWNGMVGE 486

  Fly   555 LIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVIL 619
            |:...||||::.:|||..||.|||||||||:||||||||||.|..|||||||:||:.|||:.::.
Zfish   487 LVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVF 551

  Fly   620 SYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSF 684
            :|:|||.||:.|:||.||||      |.|.|.:          :.:||  .||.|||:|.:.||.
Zfish   552 AYIGVSVVLFLVSRFSPYEW------QLDETDE----------VKDPQ--TPPDPPNDFGIFNSL 598

  Fly   685 WYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQ 749
            |:||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||:||::.|||..|
Zfish   599 WFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ 663

  Fly   750 TDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLVESP 813
            |::.||||..|||.||||||:|.::.|||.|| :|.......|..:|:.|||:||||:|.|:||.
Zfish   664 TEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFAKTTPDGVARVRKSKGKFAFLLEST 728

  Fly   814 KNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTE 878
            .|||:..|.||||||||.|:|:||:|||||.||.||..:|.|||.|.|.|.|.:::||||:||.|
Zfish   729 MNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGE 793

  Fly   879 CNL---DQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            |..   |.:..| :.||||||||::|||:|||.||::||::||..:::
Zfish   794 CGSGGGDSKDKT-SALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSR 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	123/415 (30%)
		ANF_receptor	53..434	CDD:279440	117/384 (30%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	223/402 (55%)
		Lig_chan	612..907	CDD:278489	166/298 (56%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	123/415 (30%)
		ANF_receptor	36..379	CDD:279440	118/386 (31%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	223/402 (55%)
		Lig_chan	544..824	CDD:278489	166/298 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590952
Domainoid	1	1.000	371	1.000	Domainoid score	I851
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37353
Inparanoid	1	1.050	698	1.000	Inparanoid score	I657
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm6377
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800