Protein Alignment GluRIA and GluRIIB

DIOPT Version :9

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Alignment Length: 1042
• Identity: 249/1042 - (23%)
• Similarity: 432/1042 - (41%)
• Gaps: 213/1042 - (20%)

  Fly     1 MHSRLKFLAYLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHN 65
            ||. |:||..|....|        |.|.:.      |..|.:||||......:..||..|:  ..
  Fly     1 MHG-LQFLVLLALAIA--------SGANED------TLVIKIGAIFFDTEMKLADAFSAAL--EE 48

  Fly    66 LNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVT 130
            :|..:...:|.|....:...|:..|..:.|:....||.::.|..|..:.|.:....|...:|.:.
  Fly    49 VNAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQ 113

  Fly   131 -PWFPEKV------------LAPSSGLLDFAISMRPDYHQAIIDTI--QYYGWQSIIYLYDSHDG 180
             .|.|::.            :||....|..|.|          |.:  :.:.|:|....|:....
  Fly   114 FDWHPQQSNRERMNHQLTVNVAPMELFLSAAFS----------DILASKTFDWKSFTIAYERSSH 168

  Fly   181 LLRLQQI------------YQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLD 233
            |:|||.|            .||.:.|:: :|: :.|||.|.                .:|.::||
  Fly   169 LIRLQHILAWKQLHKAGIKMQEFERGDD-YRI-LWKRINNA----------------REKFVLLD 215

  Fly   234 CPAEMAKEIIVQHVRDIKLGRRTYHYL------LSGLVMDNHWPSD-VVEFGAINITGFRIVDSN 291
            ||:::..::|...:.....|...:.:|      |||:  |..:..| .|...|:.|..:
  Fly   216 CPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGI--DGFYSRDFTVAVAAVRIRTY------ 272

  Fly   292 RRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRS 356
              .....||.....:.|..::..:.|           :.|:||::.:..
  Fly   273 --VPPPVHDEIDVFDNSVDTRFSSLG-----------SQLVYDSIVLFY---------------- 308

  Fly   357 NHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTP--------WEQGEKISRVLRK-----VE 408
                                  :|||:.:...|:..|        |:.|.::...:::     |:
  Fly   309 ----------------------NALLEISQRPGFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVK 351

  Fly   409 IDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAE-WRDDAGLL---PLHSHNYASSSRSASA 469
            ....:..::.:.||:|.::.|.|    .|..:.:|.. |..:..|:   .|..::..:..:....
  Fly   352 PPFKTQRLQINADGQREDFNLEV----YNPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQ 412

  Fly   470 STGDYDRNH-TYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQ 533
            :..|:.:.. .|.|::.:.:||.|.::...|....||:|||||..||..|||.:....:....|:
  Fly   413 NKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVR 477

  Fly   534 DGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQ 598
            |..||:.:... ..|||::.:||...|.|.|..:|||..|..|:||:.|||.|||||:..|....
  Fly   478 DNKYGSYDANT-DEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPP 541

  Fly   599 TPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATL 663
            ...:::||||.:.|:|:.|:::.:..:|.|.|..|...|||            .||...:...
  Fly   542 KADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEW------------DQPVENVNRE-- 592

  Fly   664 SEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLA 728
            .|.|        |.:.:.|:.|..|.:.:.||||:.|..:..|:..|.||.|.:::..:|.|.||
  Fly   593 MERQ--------NIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLA 649

  Fly   729 AFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHS-VHTY 792
            ||:|..::...|.:..||..|..|.:||:..|:|..:|..|....:...|..|.:.:..: ....
  Fly   650 AFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNN 714

  Fly   793 DEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVL 857
            :||:.||:.|||.||.|:|:...:|...| .|:..::|.:...|.:|:|.|:.:..|..|:..:|
  Fly   715 EEGVDRVKLSKGTYAFLMETTNLQYYVQR-NCELTQIGESFGEKHYGIAVPLNADFRSNLSVGIL 778

  Fly   858 TLKENGELLRIRNKWWFDKTE--CNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFC 920
            .|.|.|||.::||| ||:..|  |:.:..|....:..:.:|.|::.:||.|:::.:::.:.||..
  Fly   779 RLSERGELFKLRNK-WFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLW 842

  Fly   921 RNKTPQLKSPGSNGSAGGVPGMLASS-----------------TYQRDSLSDAIMHSQAKLAMQA 968
            ..:...:|..        :|.|||..                 ||::...|.:..:|..:....|
  Fly   843 HVQRISVKEK--------IPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSA 899

  Fly   969 SS 970
            ||
  Fly   900 SS 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	83/459 (18%)
		ANF_receptor	53..434	CDD:279440	76/427 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	131/405 (32%)
		Lig_chan	612..907	CDD:278489	87/297 (29%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	83/459 (18%)
		ANF_receptor	41..378	CDD:279440	77/429 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	129/397 (32%)
		Lig_chan	555..822	CDD:278489	85/290 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462512
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840