Protein Alignment GluRIA and GluRIIA

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Alignment Length: 908
• Identity: 268/908 - (29%)
• Similarity: 429/908 - (47%)
• Gaps: 126/908 - (13%)

  Fly    39 KIPLGAIFEQGTDDVQSAFKYAMLN-HNLNVSSRRF-ELQAYVDVINTADAFKLSRLICNQFSRG 101
            :|.:||||.:...:::.:|..|... :|:..|..|| .::.|:.   |.|:|.|.::.|...|.|
  Fly    31 EITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMP---TNDSFLLQQITCELISNG 92

  Fly   102 VYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLD--FAISMRPD---YHQAIID 161
            |.::.|..|..:.|.:...:|...:|.:.  :..|:.|.....|:  .:|::.|.   ..:|..:
  Fly    93 VAAIFGPSSKAASDIVAQIANATGIPHIE--YDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFE 155

  Fly   162 TIQ-YYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRF 225
            .|: .|.|::...:|::.:||.|||.: ..::..|..:  ..::.:|:.......|....| ..|
  Fly   156 IIKSNYEWRTFTLIYETPEGLARLQDL-MNIQALNSDY--VKLRNLADYADDYRILWKETD-ETF 216

  Fly   226 SKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVV--EFGAINITGFR-- 286
            .::||:|||..:..||::...: |.||.....::.|:.|...|....|:.  :|.| |||..|
  Fly   217 HEQRIILDCEPKTLKELLKVSI-DFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKA-NITSVRLK 279

  Fly   287 IVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLV-EAFNRILRKK 350
            :||:|     .|...:.||    ....|..|....||      .|:||||.:.. .|.|.|...:
  Fly   280 VVDAN-----PFERKKTRL----TKVDQILGNQTMLP------ILIYDAVVLFASSARNVIAAMQ 329

  Fly   351 PDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGL--- 412
            |     .|...| |.||||                       ||..|..|...::.:..|.:
  Fly   330 P-----FHPPNR-HCGSSS-----------------------PWMLGAFIVNEMKTISEDDVEPH 365

  Fly   413 --SGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGL------LPLHSHNYASSSRSASA 469
              :..::.||.|:||::.|.:.:.:||   :.:..|..|.|:      |.|.|          :.
  Fly   366 FKTENMKLDEYGQRIHFNLEIYKPTVN---EPMMVWTPDNGIKKRLLNLELES----------AG 417

  Fly   470 STGDY-DRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQ 533
            :|.|: ::...|.|.:..||||..:|:  ..|:..|.:::|||..||...|:..:...||..:|.
  Fly   418 TTQDFSEQRKVYTVVTHYEEPYFMMKE--DHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVN 480

  Fly   534 -DGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVK 597
             :|.|..|.:.    |||::.:||...|.|.:..:|||..|..|:||:.|||.|||||:..|...
  Fly   481 GNGKYNPETKQ----WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPP 541

  Fly   598 QTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGAT 662
            :....|:||.|.:.|:||.:|.:.:.::....|:.|....||             .||
  Fly   542 EPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREW-------------LPP------- 586

  Fly   663 LSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANL 727
              .|....|....|.:.:.||.|..:.:.|||||||.|.....||...:||||.::::|:|||||
  Fly   587 --NPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANL 649

  Fly   728 AAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHT 791
            |||||..:..:.||:.:||..|..|::|::..|||..||..|....:.:.|..| :.|......|
  Fly   650 AAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTST 714

  Fly   792 YDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAV 856
            ..||:.|||:.||.||.|:|:....| |....||..::|..|..|.:|:|.|:||..|..|:.::
  Fly   715 NKEGVARVRKEKGGYAFLMETTSLTY-NIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSI 778

  Fly   857 LTLKENGELLRIRNKWWFD-KTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF 918
            |.|.|.|||.:::||||.: ...|:...|.. .:|||:..:.|::.:|.||:|:.||:.|.||
  Fly   779 LQLSERGELQKMKNKWWKNHNVTCDSYHEVD-GDELSIIELGGVFLVLAGGVLIGVILGIFEF 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	107/438 (24%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	141/404 (35%)
		Lig_chan	610..906	CDD:459656	100/297 (34%)
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	106/429 (25%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	140/398 (35%)
		Lig_chan	555..828	CDD:459656	100/296 (34%)