Protein Alignment GluRIA and Ir25a

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 1064
• Identity: 238/1064 - (22%)
• Similarity: 419/1064 - (39%)
• Gaps: 287/1064 - (26%)

  Fly     6 KFLAYLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSS 70
            |.|..|.|:...|.|..|.::     ||   |:.|.:..|.|...:....|.:..:.....|:
  Fly    10 KILWLLGFLSLLSSFSLEIAA-----QT---TQNINVLFINEVDNEPAAKAVEVVLTYLKKNI-- 64

  Fly    71 RRFELQAYVDVI--NTADAFKLSRLICNQFSRGV------YSMLGAV-SPDSFDTLHSYSNTFQM 126
             |:.|...:|.|  |.:||..|...|||:::..:      :.:|... |..:.:|:.|::....:
  Fly    65 -RYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGL 128

  Fly   127 PFVTPWFPEKVLAPSSGLLD-----FAISMRPD---YHQAIIDTIQYYGWQSIIYLYD-----SH 178
            |.::..:.::........||     :.:.:.|.   ..:||...:.:....:...|||     .|
  Fly   129 PTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDH 193

  Fly   179 DGLLRLQQIYQE------LKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDC--P 235
            .....||.|...      .|.|... |.:.::::.|:.:...|:     ||.....|:||:.  |
  Fly   194 KYKSLLQNIQTRHVITAIAKDGKRE-REEQIEKLRNLDINNFFI-----LGTLQSIRMVLESVKP 252

  Fly   236 A----EMAKEIIVQHVRDI----------------------KLG--RRTYH-------------- 258
            |    ..|...|.|:..:|                      :||  |.||:
  Fly   253 AYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFD 317

  Fly   259 ------YLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRR--AVRDFHDSRKRLEPSGQSQSQN 315
                  ..:..::....||.| :|:  :|...|:..::.:|  .:||:.  .|..||:...
  Fly   318 LALRSFLTIKEMLQSGAWPKD-MEY--LNCDDFQGGNTPQRNLDLRDYF--TKITEPTSYG---- 373

  Fly   316 AGGPNSLPAISAQAALMYDAVFVLVEAFN--RILRKKPDQFRSNHLQRRSHGGSSSSSATGTNES 378
                            .:|.|....:.||  ..::.:.|   .|.||.|  ||||.:|.:
  Fly   374 ----------------TFDLVTQSTQPFNGHSFMKFEMD---INVLQIR--GGSSVNSKS----- 412

  Fly   379 SALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQV 443
                        :..|              |.||:.|:...::.:..|.|...|
  Fly   413 ------------IGKW--------------ISGLNSELIVKDEEQMKNLTADTV----------- 440

  Fly   444 AEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRF 508
                                                |.:.::::.|:: ::..|..:.      :
  Fly   441 ------------------------------------YRIFTVVQAPFI-MRDETAPKG------Y 462

  Fly   509 EGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAER 573
            :|||.||.:.:||.:...|.|:.|:||.:|  |....|.|:|:|.:|:.|:|||.:.:|::.|||
  Fly   463 KGYCIDLINEIAAIVHFDYTIQEVEDGKFG--NMDENGQWNGIVKKLMDKQADIGLGSMSVMAER 525

  Fly   574 ERVIDFSKPFMTL-GISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPY 637
            |.||||:.|:..| ||:||:::| .....:|.||..|...:|:.::.:|...||:::...|:.||
  Fly   526 EIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPY 589

  Fly   638 EWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPS 702
            .::..|....|...::                       ||.:....|:.:.:...||....|.:
  Fly   590 SYQNNREKYKDDEEKR-----------------------EFNLKECLWFCMTSLTPQGGGEAPKN 631

  Fly   703 IAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFF- 766
            ::||:.||.||.|..|:|:||||||||||||.|:..|:::.:||..|..:.|..|...|...:|
  Fly   632 LSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFE 696

  Fly   767 -------------------------RRSQIGL--------HNKMWEYMNANQHHSVHTYDEGIRR 798
                                     .||::.:        :.|||:.|...:..:  |.||.:.|
  Fly   697 RMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA--TLDEAVAR 759

  Fly   799 VRQSKGK--YALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKE 861
            ||.|...  :|.|.::....|:.. ..||...||.....|.:.:|...||.|:.:.|.|:|||..
  Fly   760 VRNSTAATGFAFLGDATDIRYLQL-TNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLN 823

  Fly   862 NGELLRIRNKWW-FDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF--FCRNK 923
            ..:|.:::.||| .|:.....|:.....:.:|:.|:.|::.::..|:.:|.|..:.|:  :...|
  Fly   824 KRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRK 888

  Fly   924 TPQL----KSPGSNGSAGGVPGML 943
            .|::    ::.....:|...||.|
  Fly   889 NPRIIDVAEANAERSNAADHPGKL 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	87/496 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	126/439 (29%)
		Lig_chan	610..906	CDD:459656	84/332 (25%)
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	80/450 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	125/480 (26%)