Protein Alignment GluRIA and gria4b

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_997917.2
• Gene: gria4b / 336069
• ZFINID: ZDB-GENE-030131-8013
• Length: 904
• Species: Danio rerio
• Alignment Length: 984
• Identity: 396/984 - (40%)
• Similarity: 550/984 - (55%)
• Gaps: 126/984 - (12%)

  Fly    11 LHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNL--NVSSRRF 73
            |.|.|...:....|.|:.|            :|.:|.:.||...:||:.|:..||.  |.|...|
Zfish    10 LLFSCVWGLTMGAFPSSVQ------------IGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPF 62

  Fly    74 ELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVL 138
            .|..:||.|.||::|.::...|:|:||||:::.|.....|..||.|:.....:..:||.|
Zfish    63 NLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCGALHISLITPSF----- 122

  Fly   139 APSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMV 203
             |:.|...|.:.:||....|::..:.:|.|...::|||:..|...||.|.:  |.|...::|..:
Zfish   123 -PTEGESQFVLQLRPSIRGALLSLLDHYDWNRFVFLYDTDRGYSILQAIME--KAGQNGWQVSAI 184

  Fly   204 KRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVM 266
             .:.|...| .:...||||.|..:|..|:|..||....::.|.|   .:|:  :.|||:::.|..
Zfish   185 -CVENFNDA-SYRQLLEDLDRRQEKTFVIDLEAERLNNMLEQIV---SVGKHVKGYHYIMANLGF 244

  Fly   267 DNHWPSDVVEF--GAINITGFRIVD-SNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQ 328
            .:   .::..|  |..|:|||::|| ||...:       |.::...:...:...|.::.|..:
Zfish   245 KD---INLERFMHGGANVTGFQLVDFSNPMVI-------KLMQRWNKLDQREYPGSDAPPKYT-- 297

  Fly   329 AALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTP 393
            :||.||.|.|:.|||..:.|:|.|      :.||...|                ||..:.  ..|
Zfish   298 SALTYDGVMVMAEAFRNLRRQKVD------ISRRGIAG----------------DCLANP--AAP 338

  Fly   394 WEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSH 458
            |.||..:.|.|::|.:.||:|.::||..|||:|||:.|.|:..|.. :::..|.|...|:....|
Zfish   339 WNQGIDMERTLKQVHLQGLTGNVQFDHYGRRVNYTMDVFELKSNGP-RRIGYWNDADKLVLTQDH 402

  Fly   459 NYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQL 523
            ....:..|..       .|.|.||::::|.||:.||:  ..|...||:::||||.|||..:|..:
Zfish   403 ALLPNETSGM-------ENRTVIVTTIMEGPYVMLKK--NWEMYEGNEQYEGYCVDLASEIAKHI 458

  Fly   524 GIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGI 588
            |.||:|.:|.||.|||.:.... .|:||||||:..:|:||::.:|||..||.|||||||||:|||
Zfish   459 GFKYKISIVPDGKYGARDPETK-IWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGI 522

  Fly   589 SIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQ 653
            |||||||.|..|||||||:||:.|||:.::.:|:|||.||:.|:||.||||.         |.:.
Zfish   523 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH---------TEEP 578

  Fly   654 PPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTII 718
            ..|..|   |...|      |||||.:.||.|:||.|||||||||:|.|::|||...||||||:|
Zfish   579 EEGTDG---LPSDQ------PPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 634

  Fly   719 LISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-N 782
            :||||||||||||||||||:||::.|||..|||:.||||..|||.||||||:|.::.|||.|| :
Zfish   635 IISSYTANLAAFLTVERMVSPIESAEDLAKQTDIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKS 699

  Fly   783 ANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSP 847
            |.......|..||:.|||:||||||.|:||..|||...|.||||||||.|:|:||:|||||.||.
Zfish   700 AEPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQ 764

  Fly   848 LRKRLNEAVLTLKENGELLRIRNKWWFDKTECNL---DQETSTPNELSLSNVAGIYYILIGGLLL 909
            ||..:|.|||.|.|.|.|.:::||||:||.||..   .::..:...||||||||::|||:|||.|
Zfish   765 LRSAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGGEKDKSSQALSLSNVAGVFYILVGGLGL 829

  Fly   910 AVIVAIMEFFC------------------RNKTPQLKSPGSNGSAGGV-----PGMLASSTYQRD 951
            |::||::| ||                  |||. :|...||.|..|.|     |..:.|....|.
Zfish   830 AMLVALIE-FCYKSRNEAKRMKLTFTEAMRNKA-RLSITGSVGENGRVLTPDCPKAVHSGPSLRQ 892

  Fly   952 SLSDAIMHS 960
            |...|::.|
Zfish   893 SSGLALVSS 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	124/421 (29%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	226/402 (56%)
		Lig_chan	610..906	CDD:459656	165/299 (55%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_type1	28..400	CDD:471960	125/433 (29%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	224/399 (56%)
		Lig_chan	546..826	CDD:459656	165/297 (56%)