DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GluRIIC

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	953	Identity:	239/953 - (25%)
Similarity:	394/953 - (41%)	Gaps:	180/953 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTA 85
            |..|...:.:.|      :|.:||.|.....:::..|...:...|...|.:.......:..:...
  Fly    12 WSAFFMCRSRGQ------QINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPE 70

  Fly    86 D-AFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAI 149
            | :..:....|:....||.::.|..|..:.|.:....|:..:|.:                :|.|
  Fly    71 DGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHI----------------EFDI 119

  Fly   150 S------MRPDYH--------QAII-----DTIQYYGWQSIIYLYDSHD--GLLRLQQIYQELKP 193
            |      .:|::.        |||:     |.:|.:||:....:||:.|  ...|||.:.|..:.
  Fly   120 SDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREV 184

  Fly   194 GNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSK-----KRIVLDCPAEMAKEII---------- 243
            .|:..||:.             .|..:|.....|     :|:||||...|..|::
  Fly   185 HNDVVRVRK-------------FHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTG 236

  Fly   244 -VQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEP 307
             ..|:....|...|.|  |..|..||       |..|:|||..|::.:        .|......|
  Fly   237 QYNHIFLTNLETYTDH--LEELAADN-------ETFAVNITAARLLVN--------PDPPPYSLP 284

  Fly   308 SGQ-SQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSS 371
            .|. :|..|....:|.|..:....|::||:.:..:::.......||:.
  Fly   285 YGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRM----------------- 332

  Fly   372 ATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGE---------IRFDEDGRRINY 427
                  ....:.|:.:......|..|..::|:::     |.||.         ::|||||:||.:
  Fly   333 ------VVPRITCDFAASGGRTWAMGRYLARLMK-----GTSGVNNTNFRTSILQFDEDGQRITF 386

  Fly   428 TLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYD----RNHTYIVSSLLEE 488
            .:.|.:                    ||.....|........:..:.|    :...|.|::.:..
  Fly   387 NIEVYD--------------------PLDGIGIAIWDPRGQITQLNVDVKAQKKMIYRVATRIGP 431

  Fly   489 PYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVG 553
            ||.|..:.....:|.||..::||..||.|.:|..:|.:|....|.|..||..::... .|:|::|
  Fly   432 PYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETK-QWNGIIG 495

  Fly   554 ELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVI 618
            |:|..:|.:.|..:|||..|:..:||:.|||.||:||:..|.......:.::|.|...|:||.::
  Fly   496 EIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL 560

  Fly   619 LSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNS 683
            :|...::|:...|.|....:|            :.|          .|....|.|..|::.:.|:
  Fly   561 ISVFVMTFLKTIVARISKMDW------------ENP----------HPCNRDPEVLENQWRIHNT 603

  Fly   684 FWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTM 748
            .|.::|:.|..||||.|.|...|:..|.||.|.||:.:|||||||||||..:|...|...:||:.
  Fly   604 GWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSA 668

  Fly   749 QTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYD--EGIRRVRQSKGKYALLVE 811
            |..|.:||:..|||:.....|...::...:..|| |...|.:|.|  ||:.|||:::|.|..|:|
  Fly   669 QKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMN-NDDPSAYTKDNLEGVDRVRKNRGDYMFLME 732

  Fly   812 SPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFD- 875
            :...|| :....||...||.....|.:.:|.|.|:..|..|:.|:|.|.|.|||..::.|||.:
  Fly   733 TTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNP 796

  Fly   876 KTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF 918
            ...|..:.:.....:::...:.||:|.|..|:|:|.::.|.||
  Fly   797 NASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEF 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	87/459 (19%)
		ANF_receptor	53..434	CDD:279440	84/428 (20%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	133/404 (33%)
		Lig_chan	612..907	CDD:278489	95/297 (32%)
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	90/471 (19%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	16/111 (14%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	132/395 (33%)
		Lig_chan	554..828	CDD:278489	95/297 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462515
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.940