DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Ir21a

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster

Alignment Length:	836	Identity:	168/836 - (20%)
Similarity:	287/836 - (34%)	Gaps:	242/836 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 NHWPSDVVEFG-----AINITGFRIVDSNRRAVRDFHDSRKRLEPSGQ-------SQSQNAGGPN 320
            ||:..:...||     ..|...||   ..||.|..|..:.:   |.|:       ..|.|....|
  Fly    37 NHYQLNKEIFGVGMCDGNNENEFR---QKRRIVPTFQGNPR---PRGELLASKFHVNSYNFEQTN 95

  Fly   321 SLPAISAQAA----------LMYDAV------FVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSS 369
            ||..:..:.|          :.||:.      .:|...|..|    |..|        .||..::
  Fly    96 SLVGLVNKIAQEYLNKCPPVIYYDSFVEKSDGLILENLFKTI----PITF--------YHGEINA 148

  Fly   370 SSATGTNESSALLDCNTSKGWV---------------------------TPWEQGEKISRVLRKV 407
            .........::.:||| .|.::                           |.|...:.:|..|...
  Fly   149 DYEAKNKRFTSHIDCN-CKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLRDFLSSELSSN 212

  Fly   408 EIDGL-SGEIRFDEDGRRINYTLHVVEMSV----NSTLQQVAEWRDDAGLLPLHSHNYASSSRSA 467
            .::.| .||....:..|...|.|:..::..    ::|...:..|...|...| |.:.:.|..:..
  Fly   213 IVNLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRP-HINLFPSKFQFG 276

  Fly   468 SASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLV 532
            .|       .|.:.:|:..:.|:: .:..|...|.:|..|::|....|..|::.:|
  Fly   277 FA-------GHRFQISAANQPPFI-FRIRTLDSSGMGQLRWDGVEFRLLTMISKRL--------- 324

  Fly   533 QDGNYGAENQYAP------GGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGIS-- 589
               |:..:....|      |..|.:..::|.:..||.:|.:.||  :||::|.:   |::|.|
  Fly   325 ---NFSIDITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYIT--QERLMDSA---MSVGHSPD 381

  Fly   590 --IMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQ 652
              ..|....|..|...:.:.|....:|:::|..|:|..|.:.|..|.
  Fly   382 CAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRL------------------ 428

  Fly   653 QPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAG------------ 705
                     |||....:...|.       |.|||....|....      |..|
  Fly   429 ---------TLSHLMGNWGEVE-------NMFWYVFGMFTNAF------SFTGKYSWSNTRKNST 471

  Fly   706 RIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQ 770
            |:....:|.||||:.|.||.::.||:|:...      |:.:....|      |.|.   |||
  Fly   472 RLLIGAYWLFTIIITSCYTGSIIAFVTLPAF------PDTVDSVLD------LLGL---FFR--- 518

  Fly   771 IG-LHNKMWEYMNANQHH-----------SVHTYDEGIRRVRQS-KGKYALLVESPKNEYVNARP 822
            :| |:|..||....|..|           .|.:.||||..|.|| ...||.|....:.||:....
  Fly   519 VGTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSN 583

  Fly   823 PCDTMKVGRNIDTKG-------------FGVATPIGSPLRKRLNEAVLTLKENGELLRIRNK--W 872
            ..|     .||..:.             .|...|..|..:.:::..:|..:::|.:.:|.|:  |
  Fly   584 FSD-----ENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSW 643

  Fly   873 WFDKTECNLDQETSTPN----------ELSLSNVAGIYYILIGGLLLAVIVAIMEFF--CRNKTP 925
            ...::......:.|:.|          :|:.::..|::.::..|..|.....:.|..  ..||..
  Fly   644 VMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCR 708

  Fly   926 QL-----KSPGSNGSAGGVPGMLASSTYQRDSLSDAIMHSQAKLAMQASSEYDERL 976
            |:     ||..|:.|:.....||.::..|       :.|.:.|...:.::|..:::
  Fly   709 QIIKRSRKSAASSWSSASSGSMLRTNAEQ-------LSHDKRKANRREAAEVAQKM 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	45/244 (18%)
		ANF_receptor	53..434	CDD:279440	42/221 (19%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	99/451 (22%)
		Lig_chan	612..907	CDD:278489	72/344 (21%)
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	86/369 (23%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	70/317 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910