DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Ir8a

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	152/510 - (29%)
Similarity:	249/510 - (48%)	Gaps:	87/510 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   490 YLSLKQYTYGESLVGNDR-----FEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWD 549
            ||..::.| ||.:  .||     :||||.|....|:.:|..::||...:.|:.|..|:.  |.||
  Fly   398 YLRREEGT-GELI--RDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNEL--GEWD 457

  Fly   550 GMVGELIRKEADIAISAMTITAERERVIDFSKPFM-TLGISIMIKKPVKQTPGVFSFLNPLSQEI 613
            |:||:|:|.|.|.||:|:.:.:|||.||||..|:. ..||||.|:|||::| .:|.|:..|..|:
  Fly   458 GVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRT-SLFKFMTVLRLEV 521

  Fly   614 WISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEF 678
            |:|::.:.||.:.:::|:.::.||..|                       :..||:  |....||
  Fly   522 WLSIVAALVGTAIMIWFMDKYSPYSSR-----------------------NNRQAY--PYACREF 561

  Fly   679 TMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTP 743
            |:..|||::|.:|..||....|.:|:||:..|.:|.|.:::::::|||||||||||||..|:::.
  Fly   562 TLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSL 626

  Fly   744 EDLTMQTDVNYGTLLYGSTWEFFRR------------SQIGLHN-------KMWEY--------- 780
            |.|..|:.:||..:....|.::|..            .::.|:.       ::|:|
  Fly   627 EQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHI 691

  Fly   781 -MNANQHHSVHTYDEGIRRV-RQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATP 843
             :..|....|....||...| ......||.:.:|.:.:|...| .|:..:||.....:.:.||..
  Fly   692 LLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITR-NCNLTEVGEVFAEQPYAVAVQ 755

  Fly   844 IGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKT--ECNL--DQETSTPNELSLSNVAGIYYILI 904
            .||.|...|:.|:|.|:::.....::.|:|....  .|.|  |||     .::|.::.|::...:
  Fly   756 QGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQE-----GITLESLGGVFIATL 815

  Fly   905 GGLLLAVIVAIMEFFCRNK----------TPQLKSPGSNGSAGGVPGMLASSTYQ 949
            .||:||::...||.....|          .|...|.||.|::...|....|:|.|
  Fly   816 FGLVLAMMTLGMEVLYYKKKQNALEITQVRPVNDSSGSGGNSSTAPPTATSTTKQ 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375
		ANF_receptor	53..434	CDD:279440
		PBP2_iGluR_AMPA	477..879	CDD:270433	129/426 (30%)
		Lig_chan	612..907	CDD:278489	84/328 (26%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	128/419 (31%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	84/328 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.910