DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GluRIIE

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	979	Identity:	270/979 - (27%)
Similarity:	458/979 - (46%)	Gaps:	127/979 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 HFICASSIF-------WPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVS 69
            ||:...|:|       |.::.:........|| |.:|:|.:.:|.|:.:...|.:|:...|..|.
  Fly     5 HFVILWSLFSIHISVNWAQYENFGGYDNYQSL-ESVPIGLLTDQNTEQMNIVFDHAIDVANQEVG 68

  Fly    70 SRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFP 134
            :   .|.:..:.:|..||::....:|.....|:..:.|..|..:...|.|..:...:|.:..:..
  Fly    69 T---SLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMS 130

  Fly   135 EKVLAPSSGLLDFAISMRP-DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQEL-KPGNET 197
            |.    :.|   |.:...| |..:|:...|..:.|...|:||:|.:.|..|.::...| |.|.
  Fly   131 EN----AEG---FNLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGT-- 186

  Fly   198 FRVQMVKRIANVTMAI--EFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYL 260
                 |..:....|.:  .:...|..:.:....|||:...:|...|.:.| .:.:.:....|.|:
  Fly   187 -----VITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQ-AQQVGIINEDYKYI 245

  Fly   261 LSGLVMDNH-WPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPA 324
            :..|  |.| :..:..::...||||.|:....:.||::.  ..|...|:.|.:.:|...|
  Fly   246 IGNL--DFHSFDLEEYKYSEANITGLRLFSPEKMAVKEL--LMKLGYPTDQDEFRNGSCP----- 301

  Fly   325 ISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKG 389
            |:.:.||.|||    |:.|.:.|:..|  |:.                         :..|.|:.
  Fly   302 ITVEMALTYDA----VQLFAQTLKNLP--FKP-------------------------MPQNCSQR 335

  Fly   390 WVTPWEQGEKISRVLRKVEIDG--LSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGL 452
            ..:..:.|......:|.:.:..  |:|.|.|:.:.|: .|.|.|:|:. .|.:.:|..|.:|...
  Fly   336 TESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRK-GYHLDVIELQ-PSGIVKVGTWDEDRQY 398

  Fly   453 LPLHSHNYASSSRSASASTGDYD------RNHTYIV-SSLLEEPYLSLKQYTYGESLVGNDRFEG 510
            .|          :..:.:|..:|      .|.|:|: .|:..:||..|.: || :.|.||.::||
  Fly   399 RP----------QRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVE-TY-KQLEGNSQYEG 451

  Fly   511 YCKDLADMLAAQLGIKYEIRLVQDGN-YGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERE 574
            |..||...||.:||  :....|..|| ||:.|: :.....||:.|::...||:||:.:|||:|||
  Fly   452 YGVDLIKELADKLG--FNFTFVNGGNDYGSYNK-STNESTGMLREIMTGRADLAITDLTITSERE 513

  Fly   575 RVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEW 639
            :.:||:.|||.|||:|:..||.|.||.:|:|::|.|:|:|..:..|::|||...:.:.|..|.||
  Fly   514 QALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEW 578

  Fly   640 RIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIA 704
                        ..|          .|....|....|:||:.||.|::..|.:|||.:|.|.:::
  Fly   579 ------------DNP----------YPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALS 621

  Fly   705 GRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTD-VNYGTLLYGSTWEFFRR 768
            .|..|:.|||||:|::||||||||||||:|:..:.|.:.:||....| |.||....|||..||..
  Fly   622 TRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMT 686

  Fly   769 SQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNI 833
            |....:.||.::|:.|..:......||:.||: :...||.|:||...|| |.:..|:..|:|..:
  Fly   687 SAEERYKKMNKFMSENPQYLTEDNMEGVNRVK-TNTHYAFLMESTSIEY-NTKRECNLKKIGDAL 749

  Fly   834 DTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTE--CNLDQETSTPNELSLSNV 896
            |.||:|:|.....|.|.:.|.|:|.|:|.|.|.:::||||.:...  |...::......|.::|:
  Fly   750 DEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNL 814

  Fly   897 AGIYYILIGGLLLAVIVAIMEF--FCRNKTPQLKSPGSNGSAGGVPGMLASSTYQRDSLSDAIMH 959
            .|::::|:.|...|::..|:.:  |...|....:.|..:........::..:.|.|...:.|.::
  Fly   815 EGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVLKNSASIY 879

  Fly   960 SQAK 963
            |:::
  Fly   880 SRSR 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	90/418 (22%)
		ANF_receptor	53..434	CDD:279440	81/387 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	154/406 (38%)
		Lig_chan	612..907	CDD:278489	101/297 (34%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	88/413 (21%)
		ANF_receptor	51..382	CDD:279440	82/389 (21%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	153/399 (38%)
		Lig_chan	551..824	CDD:278489	101/296 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462529
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.740