Protein Alignment GluRIA and Nmdar2

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Alignment Length: 920
• Identity: 204/920 - (22%)
• Similarity: 360/920 - (39%)
• Gaps: 237/920 - (25%)

  Fly    94 ICNQFSR-GVYSMLGAVSPDSFDTLHSYSNT---------FQMPFVTPWFPEKVLAPSSGL---- 144
            :|.:|.| .|.::|..::.:.|.  ||.::.         ..:|.:: |     .|.:|||
  Fly   167 LCKEFLRVNVSAILYMMNNEQFG--HSTASAQYFLQLAGYLGIPVIS-W-----NADNSGLERRA 223

  Fly   145 ------LDFAISMRPDYHQ--AIIDTIQYYGWQSIIYLYD---SHDGLLRLQQIYQELKPGNETF 198
                  |..|.|:.   ||  |::..::.|.|.....:..   .||..  :|.:.:.:....|.|
  Fly   224 SQSTLQLQLAPSIE---HQSAAMLSILERYKWHQFSVVTSQIAGHDDF--VQAVRERVAEMQEHF 283

  Fly   199 RVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSG 263
            :..::..|. ||...:.:..:.     |:.|::|....:.....|::...::||....|.:::|.
  Fly   284 KFTILNSIV-VTRTSDLMELVN-----SEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQ 342

  Fly   264 LVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQ 328
            .|::.                           :|.|             ||...|...:...::.
  Fly   343 SVIEK---------------------------KDAH-------------SQFPVGMLGVHFDTSS 367

  Fly   329 AALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNE---SSALLDC-NTSKG 389
            ||||           |.|         ||.::..|:|..:..:.....:   ::..|.| :..:|
  Fly   368 AALM-----------NEI---------SNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRG 412

  Fly   390 WVTPWEQGEKISRVLRKVEIDG--LSGEIRFDEDGRRINYTLHVVEM-----SVNSTLQQVAEW- 446
               .|:.||...:.||.|.|:|  ....|.|..||...:..|.::.:     :.|...:::..|
  Fly   413 ---RWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWK 474

  Fly   447 ---------RDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEE-PYLSLK--QYTYG 499
                     ||.|  .|.:||         :...|..::.|..|  :.||| ||::|.  ....|
  Fly   475 SWETQKLDIRDIA--WPGNSH---------APPQGVPEKFHLKI--TFLEEAPYINLSPADPVSG 526

  Fly   500 ESL--------------------VG----NDRF----EGYCKDLADMLAAQLGIKYEIRLVQDGN 536
            :.|                    ||    |:.|    .|:|.||.:..|.:||..||:..|:||.
  Fly   527 KCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGK 591

  Fly   537 YGA-ENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTP 600
            :|. ||    |.|:|::.:|:.::.|:.::::.|..|||.|:|||:|||..||:|::.|    ..
  Fly   592 WGTLEN----GKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RT 648

  Fly   601 GVFS---FLNPLSQEIWISV-ILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGA 661
            |:.|   ||.|.....|:.| |::....:|:::.      :||            ..|.|.....
  Fly   649 GIISPTAFLEPFDTASWMLVGIVAIQAATFMIFL------FEW------------LSPSGYDMKL 695

  Fly   662 TLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTA 725
            .|....     |.|..|::..::|...|...|....: :|.....|....||..|.::.::.|||
  Fly   696 YLQNTN-----VTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTA 755

  Fly   726 NLAAF------------LTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMW 778
            |||||            |...|:|.|      .:.:....:||:.|..|.....:....:||.|.
  Fly   756 NLAAFMITREEFHEFSGLNDSRLVHP------FSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMR 814

  Fly   779 EYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNAR-PPCDTMKVGRNIDTKGFGVAT 842
            :|...       :..:|:..|... ...:.:.:....:|:.|: ..|..|.||......|:|:|.
  Fly   815 QYNKT-------SVADGVAAVLNG-NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAF 871

  Fly   843 PIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGL 907
            ...|...:..|:.:|..:.||:|.|:| ::|...|.....||..:.:.|:|......:.:|:.|:
  Fly   872 SRNSKYVQMFNKRLLEFRANGDLERLR-RYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGI 935

  Fly   908 LLAVIVAIME 917
            |||.::.::|
  Fly   936 LLAALLLLLE 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	76/407 (19%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	115/451 (25%)
		Lig_chan	610..906	CDD:459656	66/310 (21%)
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	72/399 (18%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	115/453 (25%)