DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Nmdar2

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster

Alignment Length:	920	Identity:	204/920 - (22%)
Similarity:	360/920 - (39%)	Gaps:	237/920 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 ICNQFSR-GVYSMLGAVSPDSFDTLHSYSNT---------FQMPFVTPWFPEKVLAPSSGL---- 144
            :|.:|.| .|.::|..::.:.|.  ||.::.         ..:|.:: |     .|.:|||
  Fly   167 LCKEFLRVNVSAILYMMNNEQFG--HSTASAQYFLQLAGYLGIPVIS-W-----NADNSGLERRA 223

  Fly   145 ------LDFAISMRPDYHQ--AIIDTIQYYGWQSIIYLYD---SHDGLLRLQQIYQELKPGNETF 198
                  |..|.|:.   ||  |::..::.|.|.....:..   .||..  :|.:.:.:....|.|
  Fly   224 SQSTLQLQLAPSIE---HQSAAMLSILERYKWHQFSVVTSQIAGHDDF--VQAVRERVAEMQEHF 283

  Fly   199 RVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSG 263
            :..::..|. ||...:.:..:.     |:.|::|....:.....|::...::||....|.:::|.
  Fly   284 KFTILNSIV-VTRTSDLMELVN-----SEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQ 342

  Fly   264 LVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQ 328
            .|::.                           :|.|             ||...|...:...::.
  Fly   343 SVIEK---------------------------KDAH-------------SQFPVGMLGVHFDTSS 367

  Fly   329 AALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNE---SSALLDC-NTSKG 389
            ||||           |.|         ||.::..|:|..:..:.....:   ::..|.| :..:|
  Fly   368 AALM-----------NEI---------SNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRG 412

  Fly   390 WVTPWEQGEKISRVLRKVEIDG--LSGEIRFDEDGRRINYTLHVVEM-----SVNSTLQQVAEW- 446
               .|:.||...:.||.|.|:|  ....|.|..||...:..|.::.:     :.|...:::..|
  Fly   413 ---RWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWK 474

  Fly   447 ---------RDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEE-PYLSLK--QYTYG 499
                     ||.|  .|.:||         :...|..::.|..|  :.||| ||::|.  ....|
  Fly   475 SWETQKLDIRDIA--WPGNSH---------APPQGVPEKFHLKI--TFLEEAPYINLSPADPVSG 526

  Fly   500 ESL--------------------VG----NDRF----EGYCKDLADMLAAQLGIKYEIRLVQDGN 536
            :.|                    ||    |:.|    .|:|.||.:..|.:||..||:..|:||.
  Fly   527 KCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGK 591

  Fly   537 YGA-ENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTP 600
            :|. ||    |.|:|::.:|:.::.|:.::::.|..|||.|:|||:|||..||:|::.|    ..
  Fly   592 WGTLEN----GKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RT 648

  Fly   601 GVFS---FLNPLSQEIWISV-ILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGA 661
            |:.|   ||.|.....|:.| |::....:|:::.      :||            ..|.|.....
  Fly   649 GIISPTAFLEPFDTASWMLVGIVAIQAATFMIFL------FEW------------LSPSGYDMKL 695

  Fly   662 TLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTA 725
            .|....     |.|..|::..::|...|...|....: :|.....|....||..|.::.::.|||
  Fly   696 YLQNTN-----VTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTA 755

  Fly   726 NLAAF------------LTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMW 778
            |||||            |...|:|.|      .:.:....:||:.|..|.....:....:||.|.
  Fly   756 NLAAFMITREEFHEFSGLNDSRLVHP------FSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMR 814

  Fly   779 EYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNAR-PPCDTMKVGRNIDTKGFGVAT 842
            :|...       :..:|:..|... ...:.:.:....:|:.|: ..|..|.||......|:|:|.
  Fly   815 QYNKT-------SVADGVAAVLNG-NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAF 871

  Fly   843 PIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGL 907
            ...|...:..|:.:|..:.||:|.|:| ::|...|.....||..:.:.|:|......:.:|:.|:
  Fly   872 SRNSKYVQMFNKRLLEFRANGDLERLR-RYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGI 935

  Fly   908 LLAVIVAIME 917
            |||.::.::|
  Fly   936 LLAALLLLLE 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	75/404 (19%)
		ANF_receptor	53..434	CDD:279440	70/370 (19%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	115/451 (25%)
		Lig_chan	612..907	CDD:278489	66/309 (21%)
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	75/406 (18%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	115/453 (25%)
		Lig_chan	665..928	CDD:278489	65/300 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462559
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.890