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Protein Alignment GluRIA and Gria2

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001077280.1	Gene:	Gria2 / 29627	RGDID:	61862	Length:	883	Species:	Rattus norvegicus

Alignment Length:	952	Identity:	384/952 - (40%)
Similarity:	537/952 - (56%)	Gaps:	170/952 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRG 101
            :..|.:|.:|.:|.|...|||:..|    :..|:..|.|..::|.:..|::|.::...|:|||||
  Rat    24 SNSIQIGGLFPRGADQEYSAFRVGM----VQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 84

  Fly   102 VYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYY 166
            ||::.|.....|.:|:.|:..|..:.|:||.|      |:.|...|.|.||||...|::..|:||
  Rat    85 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSF------PTDGTHPFVIQMRPDLKGALLSLIEYY 143

  Fly   167 GWQSIIYLYDSHDGLLRLQQIYQE----------LKPGN-------ETFRVQMVKRIANVTMAIE 214
            .|....|||||..||..||.:...          :..||       ||:|
  Rat   144 QWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYR--------------- 193

  Fly   215 FLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDV--V 275
              ...:||....::|::|||..:...:|:.|   .|.:|:  :.|||:::.|...:   .|:  :
  Rat   194 --SLFQDLELKKERRVILDCERDKVNDIVDQ---VITIGKHVKGYHYIIANLGFTD---GDLLKI 250

  Fly   276 EFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLV 340
            :||..|::||:|||.:...|..|.:....||......:..|       .|...:||.||||.|:.
  Rat   251 QFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTA-------TIKYTSALTYDAVQVMT 308

  Fly   341 EAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLR 405
            ||| |.|||:..:     :.||.:.|                ||..:.  ..||.||.:|.|.|:
  Rat   309 EAF-RNLRKQRIE-----ISRRGNAG----------------DCLANP--AVPWGQGVEIERALK 349

  Fly   406 KVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNS---------------TLQQVAEWRDDAGLLPL 455
            :|:::||||.|:||::|:|||||::::|:..|.               ||.::....|.:||
  Rat   350 QVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGL--- 411

  Fly   456 HSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLA 520
                                .|.|.:|:::||.||:.:|:  ..|.|.||:|:||||.|||..:|
  Rat   412 --------------------ENKTVVVTTILESPYVMMKK--NHEMLEGNERYEGYCVDLAAEIA 454

  Fly   521 AQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMT 585
            ...|.||::.:|.||.|||.:.... .|:||||||:..:|||||:.:|||..||.|||||||||:
  Rat   455 KHCGFKYKLTIVGDGKYGARDADTK-IWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMS 518

  Fly   586 LGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIV-----RRP 645
            ||||||||||.|..|||||||:||:.|||:.::.:|:|||.||:.|:||.||||...     |..
  Rat   519 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRET 583

  Fly   646 QADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAA 710
            |:..:.                        |||.:.||.|:||.|||:|||||:|.|::|||...
  Rat   584 QSSEST------------------------NEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGG 624

  Fly   711 VWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHN 775
            ||||||:|:||||||||||||||||||:||::.|||:.||::.||||..|||.||||||:|.:.:
  Rat   625 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFD 689

  Fly   776 KMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFG 839
            |||.|| :|.....|.|..||:.|||:||||||.|:||..|||:..|.||||||||.|:|:||:|
  Rat   690 KMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG 754

  Fly   840 VATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNL---DQETSTPNELSLSNVAGIYY 901
            :|||.||.|...:|.|||.|.|.|.|.:::||||:||.||..   |.:..| :.||||||||::|
  Rat   755 IATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKT-SALSLSNVAGVFY 818

  Fly   902 ILIGGLLLAVIVAIMEFFCRN----------KTPQLKSPGSN 933
            ||:|||.||::||::||..::          |.||..:|.|:
  Rat   819 ILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSS 860

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.