DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GluRIA and Gria2

DIOPT Version :10

Sequence 1:NP_476855.1 Gene:GluRIA / 38742 FlyBaseID:FBgn0004619 Length:991 Species:Drosophila melanogaster
Sequence 2:NP_058957.1 Gene:Gria2 / 29627 RGDID:61862 Length:883 Species:Rattus norvegicus


Alignment Length:951 Identity:383/951 - (40%)
Similarity:535/951 - (56%) Gaps:168/951 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 TEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRG 101
            :..|.:|.:|.:|.|...|||:..|    :..|:..|.|..::|.:..|::|.::...|:|||||
  Rat    24 SNSIQIGGLFPRGADQEYSAFRVGM----VQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 84

  Fly   102 VYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYY 166
            ||::.|.....|.:|:.|:..|..:.|:||.|      |:.|...|.|.||||...|::..|:||
  Rat    85 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSF------PTDGTHPFVIQMRPDLKGALLSLIEYY 143

  Fly   167 GWQSIIYLYDSHDGLLRLQQIYQE----------LKPGN-------ETFRVQMVKRIANVTMAIE 214
            .|....|||||..||..||.:...          :..||       ||:|               
  Rat   144 QWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYR--------------- 193

  Fly   215 FLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDV--V 275
              ...:||....::|::|||..:...:|:.|   .|.:|:  :.|||:::.|...:   .|:  :
  Rat   194 --SLFQDLELKKERRVILDCERDKVNDIVDQ---VITIGKHVKGYHYIIANLGFTD---GDLLKI 250

  Fly   276 EFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLV 340
            :||..|::||:|||.:...|..|.:....||......:..|       .|...:||.||||.|:.
  Rat   251 QFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTA-------TIKYTSALTYDAVQVMT 308

  Fly   341 EAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLR 405
            ||| |.|||:..:     :.||.:.|                ||..:.  ..||.||.:|.|.|:
  Rat   309 EAF-RNLRKQRIE-----ISRRGNAG----------------DCLANP--AVPWGQGVEIERALK 349

  Fly   406 KVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNS---------------TLQQVAEWRDDAGLLPL 455
            :|:::||||.|:||::|:|||||::::|:..|.               ||.::....|.:||   
  Rat   350 QVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGL--- 411

  Fly   456 HSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLA 520
                                .|.|.:|:::||.||:.:|:  ..|.|.||:|:||||.|||..:|
  Rat   412 --------------------ENKTVVVTTILESPYVMMKK--NHEMLEGNERYEGYCVDLAAEIA 454

  Fly   521 AQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMT 585
            ...|.||::.:|.||.|||.:.... .|:||||||:..:|||||:.:|||..||.|||||||||:
  Rat   455 KHCGFKYKLTIVGDGKYGARDADTK-IWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMS 518

  Fly   586 LGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIV-----RRP 645
            ||||||||||.|..|||||||:||:.|||:.::.:|:|||.||:.|:||.||||...     |..
  Rat   519 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRET 583

  Fly   646 QADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAA 710
            |:..:.                        |||.:.||.|:||.|||:|||||:|.|::|||...
  Rat   584 QSSEST------------------------NEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGG 624

  Fly   711 VWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHN 775
            ||||||:|:||||||||||||||||||:||::.|||:.||::.||||..|||.||||||:|.:.:
  Rat   625 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFD 689

  Fly   776 KMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFG 839
            |||.|| :|.....|.|..||:.|||:||||||.|:||..|||:..|.||||||||.|:|:||:|
  Rat   690 KMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG 754

  Fly   840 VATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETS--TPNELSLSNVAGIYYI 902
            :|||.||.|...:|.|||.|.|.|.|.:::||||:||.||......|  ..:.||||||||::||
  Rat   755 IATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYI 819

  Fly   903 LIGGLLLAVIVAIMEFFCRN----------KTPQLKSPGSN 933
            |:|||.||::||::||..::          |.||..:|.|:
  Rat   820 LVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSS 860

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIANP_476855.1 PBP1_iGluR_AMPA 41..456 CDD:380603 134/450 (30%)
PBP2_iGluR_AMPA 477..879 CDD:270433 220/407 (54%)
Lig_chan 610..906 CDD:459656 158/303 (52%)
Gria2NP_058957.1 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 129/433 (30%)
PBP2_iGluR_AMPA 413..794 CDD:270433 220/407 (54%)
Required for interaction with IQSEC1. /evidence=ECO:0000269|PubMed:20547133 867..877
Blue background indicates that the domain is not in the aligned region.

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