back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grik1

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001104587.1	Gene:	Grik1 / 29559	RGDID:	2732	Length:	949	Species:	Rattus norvegicus

Alignment Length:	962	Identity:	326/962 - (33%)
Similarity:	508/962 - (52%)	Gaps:	170/962 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFE----QGTDDVQSAFKYAMLNHNLN---- 67
            |:|:|   ...|:.|           .:.:.:|.|||    :..:..:.|||:|:.:.|.|
  Rat    22 LYFLC---YILPQTS-----------PQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLM 72

  Fly    68 -VSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFV-T 130
             .::..:::|.    ||..|:|:.||..|:|.:.||.::.|.....|...:.|..|..::|.: |
  Rat    73 PNTTLTYDIQR----INLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQT 133

  Fly   131 PWFPEKVLAPSSGLLD-FAISMRPDY---HQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQI---- 187
            .|     ..||....| |.|::.|||   .:|::|.:.||.|:::..:|:...||:|||::
  Rat   134 RW-----KHPSVDSRDLFYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQELIKAP 193

  Fly   188 --------YQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIV 244
                    .::|.|.|:..:                 ..|:::.:..:..::.||..|.|.||:.
  Rat   194 SRYNIKIKIRQLPPANKDAK-----------------PLLKEMKKSKEFYVIFDCSHETAAEILK 241

  Fly   245 QHVRDIKLGRRT--YHYLLSGL---VMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHD--SR 302
            |   .:.:|..|  |||..:.|   .:|    .::..:..:|:||||:::.:...|....:  |.
  Rat   242 Q---ILFMGMMTEYYHYFFTTLDLFALD----LELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSM 299

  Fly   303 KRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGS 367
            :||:...:.::....|     .::.:||||||||:::..|                    ||..|
  Rat   300 ERLQAPPRPETGLLDG-----MMTTEAALMYDAVYMVAIA--------------------SHRAS 339

  Fly   368 SSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDE-DGRRINYTLHV 431
            ..:.::        |.|:..|    ||..|.:...::::...|||:|.|.|:: ||.|.::.|.:
  Rat   340 QLTVSS--------LQCHRHK----PWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDI 392

  Fly   432 VEMSVNST--------------LQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIV 482
            :.:....|              .:::..|..::||      |....:|..|.:..|...|.|.||
  Rat   393 ISLKEEGTEKASGEVSKHLYKVWKKIGIWNSNSGL------NMTDGNRDRSNNITDSLANRTLIV 451

  Fly   483 SSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGG 547
            :::|||||:..::  ..:.|.|||||||||.||...|:..||..|:::||.||.|||:|.  .|.
  Rat   452 TTILEEPYVMYRK--SDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQND--KGE 512

  Fly   548 WDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQE 612
            |:|||.|||...||:|::.:|||..||:|||||||||||||||:.:||....|||||||||||.:
  Rat   513 WNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPD 577

  Fly   613 IWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNE 677
            ||:.|:|:.:|||.||:.:.||.||||........||                      .|..|.
  Rat   578 IWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDS----------------------DVVENN 620

  Fly   678 FTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKT 742
            ||:|||||:.:.|.||||.::.|.:::.||...:|||||:|:|||||||||||||||||.:||.:
  Rat   621 FTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 685

  Fly   743 PEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHS-VHTYDEGIRRVRQSKGKY 806
            .:||..||.:.||.:..|||..||::|:|..:.|||.:|::.|..: |...||||:||..:  .|
  Rat   686 ADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTT--DY 748

  Fly   807 ALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNK 871
            |||:||...|||..| .|:..::|..||:||:||.||||||.|.::..|:|.|:|.|:|..::.|
  Rat   749 ALLMESTSIEYVTQR-NCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEK 812

  Fly   872 WWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            || ....|. ::::...:.|.:.|:.||:.:|..||:|:|.|||.||..:::
  Rat   813 WW-RGNGCP-EEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFLYKSR 862

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.