Protein Alignment GluRIA and GRIN2C

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_054171851.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 1075
• Identity: 217/1075 - (20%)
• Similarity: 372/1075 - (34%)
• Gaps: 314/1075 - (29%)

  Fly    17 SSIF--WPEFSSAQ-QQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAY 78
            :|:|  |......| :|..||         |:....:...|:.|:            .|...|::
Human    12 TSLFGAWAGLGPGQGEQGMTV---------AVVFSSSGPPQAQFR------------ARLTPQSF 55

  Fly    79 VDV----------INTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDT------LHSYSNTFQMP 127
            :|:          :||.:...|...||...  |...:.|.|..|:.||      |...|:...:|
Human    56 LDLPLEIQPLTVGVNTTNPSSLLTQICGLL--GAAHVHGIVFEDNVDTEAVAQILDFISSQTHVP 118

  Fly   128 F----------VTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDG-- 180
            .          :||      ..|.|..|...:|:.... |.:...::.|.|.:...:...|.|
Human   119 ILSISGGSAVVLTP------KEPGSAFLQLGVSLEQQL-QVLFKVLEEYDWSAFAVITSLHPGHA 176

  Fly   181 -LLR---------------LQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKR 229
             .|.               |..:..||.||....|.|.:.|..:..:.:.:
Human   177 LFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAY-------------- 227

  Fly   230 IVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNH-WPSDVVEFGAINITGFRIVDSNRR 293
                |..|.|:.:..:..:             :|||...| |
Human   228 ----CSREEAEVLFAEAAQ-------------AGLVGPGHVW----------------------- 252

  Fly   294 AVRDFHDSRKRLEPS---GQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFR 355
                       |.|:   |.:.:..|..|..|             :.|:.|::...||:|   .|
Human   253 -----------LVPNLALGSTDAPPATFPVGL-------------ISVVTESWRLSLRQK---VR 290

  Fly   356 SN--------HLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGL 412
            ..        |...|.||...:.:.          ||....|.|:|  ..|...|.|..|..:|
Human   291 DGVAILALGAHSYWRQHGTLPAPAG----------DCRVHPGPVSP--AREAFYRHLLNVTWEG- 342

  Fly   413 SGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRN 477
             .:..|...|..:..|:.|:.::.:...:.|..|  :.|:|.:   .|....|.:::.....|..
Human   343 -RDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRW--EHGVLYM---KYPVWPRYSASLQPVVDSR 401

  Fly   478 HTYIVSSLLEEPYLSLKQYTYGES----------LVGNDRF-------------EGYCKDLADML 519
            | ..|::|.|.|::.::....|..          ...|..|             :|:|.|:...|
Human   402 H-LTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKL 465

  Fly   520 AAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFM 584
            |..:...|::.||.:|.:|   :...|.|:||:||:..|.||:||.::||..||..::|||.||:
Human   466 ARVVKFSYDLYLVTNGKHG---KRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFV 527

  Fly   585 TLGISIMIKKPVKQTPGVFSFLNPLSQEIWISV-ILSYVGVSFVLYFVTRFPP--YEWRIVRRPQ 646
            ..|||:|:.:. ..|....:||.|.|..:|:.: ::....|:..::....|.|  |...:.|..:
Human   528 ETGISVMVARS-NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKK 591

  Fly   647 ADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAA 710
            :...|                          ||:..|.|...|........| .|.....:|...
Human   592 SGGPA--------------------------FTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVL 630

  Fly   711 VWWFFTIILISSYTANLAAFLTVERMVAPI---------------------KT--------PEDL 746
            ||.||.:|.::|||||||||:..|:.:..:                     ||        |:|
Human   631 VWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKSLHLENTGVAWTAFKTFCSDYFQRPQD- 694

  Fly   747 TMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVE 811
             ......:||:..|||....|.:...:|..|.::...:...::.:...|.......:...|.:.:
Human   695 -QYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGSEAQPVPRKLDAFIYD 758

  Fly   812 SPKNEYVNARPP-CD--TMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWW 873
            :....|:..:.. |.  |:..|:...|.|:|:|....|..::.::.|:|....:||..::...|.
Human   759 AAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL 823

  Fly   874 FDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIME--------------------- 917
              ...|..::.....::|.:.|:||::|:|:..:.||::|...|
Human   824 --SGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLL 886

  Fly   918 ------FFCRNKTPQLKSPGSNGSAGGVPGMLASS 946
                  :.|.:....|.||....|    |.:.|||
Human   887 AFSRGIYSCFSGVQSLASPPRQAS----PDLTASS 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	82/470 (17%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	105/460 (23%)
		Lig_chan	610..906	CDD:459656	66/331 (20%)
GRIN2C	XP_054171851.1	PBP1_iGluR_NMDA_NR2	28..384	CDD:380601	85/485 (18%)
		PBP2_iGluR_NMDA_Nr2	400..829	CDD:270436	106/463 (23%)
		NMDAR2_C	866..>941	CDD:463148	9/56 (16%)