DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GluRIA and GRIN2C

DIOPT Version :9

Sequence 1:NP_476855.1 Gene:GluRIA / 38742 FlyBaseID:FBgn0004619 Length:991 Species:Drosophila melanogaster
Sequence 2:XP_016880033.1 Gene:GRIN2C / 2905 HGNCID:4587 Length:1337 Species:Homo sapiens


Alignment Length:1075 Identity:217/1075 - (20%)
Similarity:372/1075 - (34%) Gaps:314/1075 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SSIF--WPEFSSAQ-QQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAY 78
            :|:|  |......| :|..||         |:....:...|:.|:            .|...|::
Human    87 TSLFGAWAGLGPGQGEQGMTV---------AVVFSSSGPPQAQFR------------ARLTPQSF 130

  Fly    79 VDV----------INTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDT------LHSYSNTFQMP 127
            :|:          :||.:...|...||...  |...:.|.|..|:.||      |...|:...:|
Human   131 LDLPLEIQPLTVGVNTTNPSSLLTQICGLL--GAAHVHGIVFEDNVDTEAVAQILDFISSQTHVP 193

  Fly   128 F----------VTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDG-- 180
            .          :||      ..|.|..|...:|:.... |.:...::.|.|.:...:...|.|  
Human   194 ILSISGGSAVVLTP------KEPGSAFLQLGVSLEQQL-QVLFKVLEEYDWSAFAVITSLHPGHA 251

  Fly   181 -LLR---------------LQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKR 229
             .|.               |..:..||.||....|.|.:.|..:..:.:.:              
Human   252 LFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAY-------------- 302

  Fly   230 IVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNH-WPSDVVEFGAINITGFRIVDSNRR 293
                |..|.|:.:..:..:             :|||...| |                       
Human   303 ----CSREEAEVLFAEAAQ-------------AGLVGPGHVW----------------------- 327

  Fly   294 AVRDFHDSRKRLEPS---GQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFR 355
                       |.|:   |.:.:..|..|..|             :.|:.|::...||:|   .|
Human   328 -----------LVPNLALGSTDAPPATFPVGL-------------ISVVTESWRLSLRQK---VR 365

  Fly   356 SN--------HLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGL 412
            ..        |...|.||...:.:.          ||....|.|:|  ..|...|.|..|..:| 
Human   366 DGVAILALGAHSYWRQHGTLPAPAG----------DCRVHPGPVSP--AREAFYRHLLNVTWEG- 417

  Fly   413 SGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRN 477
             .:..|...|..:..|:.|:.::.:...:.|..|  :.|:|.:   .|....|.:::.....|..
Human   418 -RDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRW--EHGVLYM---KYPVWPRYSASLQPVVDSR 476

  Fly   478 HTYIVSSLLEEPYLSLKQYTYGES----------LVGNDRF-------------EGYCKDLADML 519
            | ..|::|.|.|::.::....|..          ...|..|             :|:|.|:...|
Human   477 H-LTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKL 540

  Fly   520 AAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFM 584
            |..:...|::.||.:|.:|   :...|.|:||:||:..|.||:||.::||..||..::|||.||:
Human   541 ARVVKFSYDLYLVTNGKHG---KRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFV 602

  Fly   585 TLGISIMIKKPVKQTPGVFSFLNPLSQEIWISV-ILSYVGVSFVLYFVTRFPP--YEWRIVRRPQ 646
            ..|||:|:.:. ..|....:||.|.|..:|:.: ::....|:..::....|.|  |...:.|..:
Human   603 ETGISVMVARS-NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKK 666

  Fly   647 ADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAA 710
            :...|                          ||:..|.|...|........| .|.....:|...
Human   667 SGGPA--------------------------FTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVL 705

  Fly   711 VWWFFTIILISSYTANLAAFLTVERMVAPI---------------------KT--------PEDL 746
            ||.||.:|.::|||||||||:..|:.:..:                     ||        |:| 
Human   706 VWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKSLHLENTGVAWTAFKTFCSDYFQRPQD- 769

  Fly   747 TMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVE 811
             ......:||:..|||....|.:...:|..|.::...:...::.:...|.......:...|.:.:
Human   770 -QYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGSEAQPVPRKLDAFIYD 833

  Fly   812 SPKNEYVNARPP-CD--TMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWW 873
            :....|:..:.. |.  |:..|:...|.|:|:|....|..::.::.|:|....:||..::...|.
Human   834 AAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL 898

  Fly   874 FDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIME--------------------- 917
              ...|..::.....::|.:.|:||::|:|:..:.||::|...|                     
Human   899 --SGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLL 961

  Fly   918 ------FFCRNKTPQLKSPGSNGSAGGVPGMLASS 946
                  :.|.:....|.||....|    |.:.|||
Human   962 AFSRGIYSCFSGVQSLASPPRQAS----PDLTASS 992

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIANP_476855.1 PBP1_iGluR_AMPA 41..453 CDD:107375 81/467 (17%)
ANF_receptor 53..434 CDD:279440 77/436 (18%)
PBP2_iGluR_AMPA 477..879 CDD:270433 105/460 (23%)
Lig_chan 612..907 CDD:278489 65/330 (20%)
GRIN2CXP_016880033.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155745
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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