Protein Alignment GluRIA and GRIN2A

DIOPT Version :9

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Alignment Length: 1000
• Identity: 216/1000 - (21%)
• Similarity: 372/1000 - (37%)
• Gaps: 260/1000 - (26%)

  Fly    44 AIFEQGTDDVQSAFKYAMLNHNLNVSSRRFE----------LQAYVDVI----NTADAFKLSRLI 94
            |..|:|...:..|   .||.|:.:|:.|...          |...|:|:    |..|...|...:
Human    77 AAAEKGPPALNIA---VMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHV 138

  Fly    95 CNQFS---------------RGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLA---PS 141
            |:..|               ..|..||..:|..:|..:........|          ::|   |:
Human   139 CDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASM----------IMADKDPT 193

  Fly   142 SGLLDFAISMRPDYHQA--IIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVK 204
            |....|..|::   .||  ::..:|.|.|              .:..:...:.||...| :..||
Human   194 STFFQFGASIQ---QQATVMLKIMQDYDW--------------HVFSLVTTIFPGYREF-ISFVK 240

  Fly   205 -------------RIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRT 256
                         .:..:..:.|...|...|.:.....|:|.|..:.| .:|:...|.:.|....
Human   241 TTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEA-VLILSEARSLGLTGYD 304

  Fly   257 YHYLLSGLVMDN------HWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQN 315
            :.:::..||..|      .:||     |.|:::              :.|....||
Human   305 FFWIVPSLVSGNTELIPKEFPS-----GLISVS--------------YDDWDYSLE--------- 341

  Fly   316 AGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSA 380
                          |.:.|.:.:|..|            .|:.|::.|:...:.:|..|..|
Human   342 --------------ARVRDGIGILTTA------------ASSMLEKFSYIPEAKASCYGQME--- 377

  Fly   381 LLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAE 445
                       .|......:...:..|..||  .::.|.|:|.:::..|.|:.::.:...::|.:
Human   378 -----------RPEVPMHTLHPFMVNVTWDG--KDLSFTEEGYQVHPRLVVIVLNKDREWEKVGK 429

  Fly   446 WRDDAGLLPLH--SHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQY-TYGESLVGND- 506
            |.:       |  |..:|...|..|.|..:.|.||..|| :|.|.|::.::.. ...|:.|.|.
Human   430 WEN-------HTLSLRHAVWPRYKSFSDCEPDDNHLSIV-TLEEAPFVIVEDIDPLTETCVRNTV 486

  Fly   507 ---RF-----------------EGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGM 551
               :|                 :|:|.|:...|:..:...|::.||.:|.:|.:   ....|:||
Human   487 PCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKK---VNNVWNGM 548

  Fly   552 VGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWIS 616
            :||::.:.|.:|:.::||..||..|:|||.||:..|||:|:.:. ..|....:||.|.|..:|:.
Human   549 IGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS-NGTVSPSAFLEPFSASVWVM 612

  Fly   617 VILSYVGVSFVLYFVTR-FPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTM 680
            :.:..:.||.:..||.. |.|..:   .|..|...|...|                     .||:
Human   613 MFVMLLIVSAIAVFVFEYFSPVGY---NRNLAKGKAPHGP---------------------SFTI 653

  Fly   681 LNSFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPE 744
            ..:.|............: .|.....:|..:||.||.:|.::|||||||||:..|..|..:....
Human   654 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLS 718

  Fly   745 DLTMQTDVNY------GTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIR--RVRQ 801
            |...|...:|      ||:..|||....|.:...:|..|.::   ||        :|:.  .|..
Human   719 DKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKF---NQ--------KGVEDALVSL 772

  Fly   802 SKGKY-ALLVESPKNEYVNARPP-CDTMKVGRN--IDTKGFGVATPIGSPLRKRLNEAVLTLKEN 862
            ..||. |.:.::....|...|.. |..:.:|..  ..|.|:|:|...|||.:::::.|:|....:
Human   773 KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGD 837

  Fly   863 GELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF-------FC 920
            ||:..:...|.  ...|:.::.....::|.:.|:||::|:|...:.|::|..|.|.       ||
Human   838 GEMEELETLWL--TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFC 900

  Fly   921 RNKTPQLKSPGSNGSAGGVPGMLAS 945
                       ..|.....||:|.|
Human   901 -----------FTGVCSDRPGLLFS 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	79/461 (17%)
		ANF_receptor	53..434	CDD:279440	74/433 (17%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	112/437 (26%)
		Lig_chan	612..907	CDD:278489	73/308 (24%)
GRIN2A	XP_016878661.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810