DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GRIK5

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens

Alignment Length:	1005	Identity:	317/1005 - (31%)
Similarity:	491/1005 - (48%)	Gaps:	178/1005 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FEQGTDDVQSAFKYAMLNHNLNVSSR---------RFELQAYVDVINTA----DAFKLSR----- 92
            |...:..|.|:.:.|.:..:..|..|         |.::...::|...|    |.|:|.|
Human    13 FASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYE 77

  Fly    93 ---LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFA-ISMR 152
               .:|....:||.|:|| :.||.|..|:.......::|.:... ||:  .|....|.|| :|:.
Human    78 TTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG-PEE--TPRLQYLRFASVSLY 139

  Fly   153 P---DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIE 214
            |   |...|:...::.:.:.|...:....:.||||:::.:......||..|:|:....:.|
Human   140 PSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPT---- 200

  Fly   215 FLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLS----------GLVMDNH 269
              ..|:::.......|::|..|.:: .:|::...::.:....|.|:|:          |:|.|:.
Human   201 --PLLKEIRDDKVSTIIIDANASIS-HLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSS 262

  Fly   270 WPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSL-PAISAQAALMY 333
                       ||.||.:.:::.....:|      :.....|..:|......| ||:|  ||||:
Human   263 -----------NILGFSMFNTSHPFYPEF------VRSLNMSWRENCEASTYLGPALS--AALMF 308

  Fly   334 DAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGE 398
            |||.|:|.|.             ..|.|....|....:.|..|                .|..|.
Human   309 DAVHVVVSAV-------------RELNRSQEIGVKPLACTSAN----------------IWPHGT 344

  Fly   399 KISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASS 463
            .:...||.||.|||:|.:.|:..|:|.||||.::|.| ....:::..|             |::.
Human   345 SLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKS-RQGHREIGVW-------------YSNR 395

  Fly   464 SRSASASTGDYD-----RNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQL 523
            :.:.:|:|.|.:     .|.|.:|:::||.||: :::..: ::|.||:||||:|.|:...||..|
Human   396 TLAMNATTLDINLSQTLANKTLVVTTILENPYV-MRRPNF-QALSGNERFEGFCVDMLRELAELL 458

  Fly   524 GIKYEIRLVQDGNYGAENQYAPGGWDGMVGELI-RKEADIAISAMTITAERERVIDFSKPFMTLG 587
            ..:|.:|||:||.|||..  ..|.|.||||||| |::||:|::|.|||||||:||||||||||||
Human   459 RFRYRLRLVEDGLYGAPE--PNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLG 521

  Fly   588 ISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQ 652
            |||:.:..:.:.||.||||:|.|..:|:.::|:|:.||.||:...|..||||   ..|.....|:
Human   522 ISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW---YNPHPCLRAR 583

  Fly   653 QPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTI 717
                              |.:..|::|:.||.|:.:..|||||.:|.|.:::.|..:.|||.||:
Human   584 ------------------PHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTL 630

  Fly   718 ILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMN 782
            |:||||||||||||||:||..|:::.:||..||::.|||:..|||..||:.|:...:.:||.||.
Human   631 IIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQ 695

  Fly   783 ANQHH-SVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGS 846
            :.|.. .|.:.:|||.||..|  :||.|:||..||| :.|..|:..::|..:||||:|:..|:||
Human   696 SKQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKGYGIGMPLGS 757

  Fly   847 PLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAV 911
            |.|..:..|:|.|:||..|..::.||| :...|. .:|......|.:.|:.||:.:||.||::||
Human   758 PFRDEITLAILQLQENNRLEILKRKWW-EGGRCP-KEEDHRAKGLGMENIGGIFIVLICGLIIAV 820

  Fly   912 IVAIMEFFCRNK-------TPQLKSPGSNGSAGG--------------VPGMLASSTYQRDSLSD 955
            .||:|||....:       ||.|.......||.|              ||.......:.|.||..
Human   821 FVAVMEFIWSTRRSAESEETPALHPAACQCSALGPRTPLKEPSMLLVKVPSTRVQVAFSRTSLRQ 885

  Fly   956 A----IMHSQAKLAMQASSEYDERLVGVEL 981
            .    :.|       |.||.|..:...|::
Human   886 VCPFLLQH-------QLSSLYWIQATNVQI 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	101/443 (23%)
		ANF_receptor	53..434	CDD:279440	97/417 (23%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	178/403 (44%)
		Lig_chan	612..907	CDD:278489	114/295 (39%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	99/445 (22%)
		ANF_receptor	42..379	CDD:279440	92/394 (23%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	178/399 (45%)
		Lig_chan	546..816	CDD:278489	114/295 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155751
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.780