Protein Alignment GluRIA and GRIK4

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_055434.2
• Gene: GRIK4 / 2900
• HGNCID: 4582
• Length: 956
• Species: Homo sapiens
• Alignment Length: 891
• Identity: 289/891 - (32%)
• Similarity: 451/891 - (50%)
• Gaps: 137/891 - (15%)

  Fly    76 QAYVDVINTADAFKLSR--------LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMP---- 127
            :|.|:|    |.|:|.|        .:|....:||.::|| :.||.|...:.:.....::|
Human    61 KAKVEV----DIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKV 121

  Fly   128 -------FVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQ 185
                   |....|....|.||:          .|...|:...:.::...:...:....:.||.|:
Human   122 APEEFVKFQFQRFTTLNLHPSN----------TDISVAVAGILNFFNCTTACLICAKAECLLNLE 176

  Fly   186 QIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDI 250
            ::.::.....:|..|:|:....:.|      ..|:::.......|::...|.|:..|::: ..::
Human   177 KLLRQFLISKDTLSVRMLDDTRDPT------PLLKEIRDDKTATIIIHANASMSHTILLK-AAEL 234

  Fly   251 KLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQN 315
            .:....|.|:.:.|.........:|: ..:||.||.|.:.:....::|..|   |..|.|....:
Human   235 GMVSAYYTYIFTNLEFSLQRMDSLVD-DRVNILGFSIFNQSHAFFQEFAQS---LNQSWQENCDH 295

  Fly   316 AGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSA 380
            .  |.:.||:|  :||::|||:.:|.|...:.|                     |...|...
Human   296 V--PFTGPALS--SALLFDAVYAVVTAVQELNR---------------------SQEIGVKP--- 332

  Fly   381 LLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAE 445
             |.|.:::    .|:.|..:...||.||::||:|.|.|:..|:|.||.|.:::.:.|. .:|:.:
Human   333 -LSCGSAQ----IWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNG-FRQIGQ 391

  Fly   446 WRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYG--ESLVGNDRF 508
            |....| |.:.||.|||       :..|...|.|.:|:::||.|||.||    |  :.:.||||:
Human   392 WHVAEG-LSMDSHLYAS-------NISDTLFNTTLVVTTILENPYLMLK----GNHQEMEGNDRY 444

  Fly   509 EGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAER 573
            ||:|.|:...||..|...|:||||.||.||...  |.|.|.|||||||.::||:|::.:||||||
Human   445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE--ANGTWTGMVGELIARKADLAVAGLTITAER 507

  Fly   574 ERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYE 638
            |:|||||||||||||||:.:..:.:.||.||||:|.|..:|:.::|:|:.||.||:.|.|..|||
Human   508 EKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYE 572

  Fly   639 WRIVRRPQADSTAQQP-PGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPS 702
            |            ..| |...|...|.          .|::::.||.|:.:..|||||..|.|.:
Human   573 W------------YSPHPCAQGRCNLL----------VNQYSLGNSLWFPVGGFMQQGSTIAPRA 615

  Fly   703 IAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFR 767
            ::.|..:.|||.||:|:||||||||||||||:||..||::.:||..||.:.|||:..||:..||:
Human   616 LSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQ 680

  Fly   768 RSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGR 831
            .|:...:.:||.||.:.|.. .|.:.:|||.||..|  .||.|:||..|||...| .|:..::|.
Human   681 NSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS--NYAFLLESTMNEYYRQR-NCNLTQIGG 742

  Fly   832 NIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNV 896
            .:||||:|:..|:||..|...:.|:|.|:||..|..::.||| :..:|. .:|......|.:.|:
Human   743 LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWW-EGGKCP-KEEDHRAKGLGMENI 805

  Fly   897 AGIYYILIGGLLLAVIVAIMEFF-------------CRNKTPQLKS 929
            .||:.:||.||::|:.:|::||.             |:....:|:|
Human   806 GGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVCQEMVTELRS 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	86/399 (22%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	180/405 (44%)
		Lig_chan	610..906	CDD:459656	115/297 (39%)
GRIK4	NP_055434.2	PBP1_iGluR_Kainate_KA1_2	24..402	CDD:380616	86/400 (22%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	180/401 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956