DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GRIK3

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens

Alignment Length:	968	Identity:	315/968 - (32%)
Similarity:	509/968 - (52%)	Gaps:	150/968 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RLKFLAYLHF----ICASSIFW-PEFSSAQQQQQTVSLTEKIPLGAIFE-------QGTDDVQSA 56
            ||:.|.:.::    :||   || |:         :..:...|.:|.|||       |..:..:.|
Human     7 RLRSLVWEYWAGLLVCA---FWIPD---------SRGMPHVIRIGGIFEYADGPNAQVMNAEEHA 59

  Fly    57 FKYA--MLNHN---LNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDT 116
            |:::  ::|.|   |..::..:::|.    |:..|:|:.::..|:|.:.||.::.|.......:.
Human    60 FRFSANIINRNRTLLPNTTLTYDIQR----IHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA 120

  Fly   117 LHSYSNTFQMPFV-TPWFPEKVLAPSSGLLDFAISMRPDY---HQAIIDTIQYYGWQSIIYLYDS 177
            :.|..|..::|.: ..|...    |......|.:::.|||   ..||:|.:||..|:|...:||.
Human   121 VQSICNALEVPHIQLRWKHH----PLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDD 181

  Fly   178 HDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEI 242
            ..||:|||::.......|...:::.:...::.:..:     |:::.|..:.||:.||...||.:|
Human   182 STGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPL-----LKEMKRGREFRIIFDCSHTMAAQI 241

  Fly   243 IVQHVRDIKLGRRT--YHYLLSGL---VMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHD-- 300
            :.|   .:.:|..|  ||::.:.|   .:|    .:...:..:|:|||||::.:...|....:
Human   242 LKQ---AMAMGMMTEYYHFIFTTLDLYALD----LEPYRYSGVNLTGFRILNVDNPHVSAIVEKW 299

  Fly   301 SRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHG 365
            |.:||:.:.:|:|....|     .:...|||:||||.::...:.|     ..|...|.||
Human   300 SMERLQAAPRSESGLLDG-----VMMTDAALLYDAVHIVSVCYQR-----APQMTVNSLQ----- 349

  Fly   366 GSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDE-DGRRINYTL 429
                              |:..|.    |..|.:....:::.:.:||:|.|.|:: .|.|.::.|
Human   350 ------------------CHRHKA----WRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDL 392

  Fly   430 HVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLK 494
            .::.:..:. |::|..|....||      |....::....:..|...|.:.||:::||||::..:
Human   393 DIISLKEDG-LEKVGVWSPADGL------NITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFR 450

  Fly   495 QYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKE 559
            :  ...:|.|||||||||.||...||..||..||||||:||.|||::.  .|.|:|||.|||..:
Human   451 K--SDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDD--KGQWNGMVKELIDHK 511

  Fly   560 ADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGV 624
            ||:|::.:|||..||:.|||||||||||:||:.:||....|.|||||||||.:||:.|:|:|:||
Human   512 ADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGV 576

  Fly   625 SFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLA 689
            |.||:.:.||.||||       .|:....|     |:.:.|          |.||:|||||:.:.
Human   577 SCVLFVIARFSPYEW-------YDAHPCNP-----GSEVVE----------NNFTLLNSFWFGMG 619

  Fly   690 AFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNY 754
            :.||||.::.|.:::.||...:|||||:|:|||||||||||||||||.:||.:.:||..||.:.|
Human   620 SLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY 684

  Fly   755 GTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVN 819
            |.:..|:|..||::|:|....|||.:|::.....|...:|||:|...:  .||||:||...|||.
Human   685 GAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTA--DYALLMESTTIEYVT 747

  Fly   820 ARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQE 884
            .| .|:..::|..||:||:|:.||:|||.|.::..|:|.|:|..:|..::.||| ..:.|. ::|
Human   748 QR-NCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWW-RGSGCP-EEE 809

  Fly   885 TSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF--------------FCRNKTPQLK 928
            ....:.|.:..:.||:.:|..||:|:|:||:.||              ||.....:::
Human   810 NKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIR 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	100/435 (23%)
		ANF_receptor	53..434	CDD:279440	91/397 (23%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	187/401 (47%)
		Lig_chan	612..907	CDD:278489	118/294 (40%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	103/446 (23%)
		ANF_receptor	55..398	CDD:279440	91/399 (23%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	187/397 (47%)
		Lig_chan	564..832	CDD:278489	118/294 (40%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.680