Protein Alignment GluRIA and GRIK2

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_068775.1
• Gene: GRIK2 / 2898
• HGNCID: 4580
• Length: 908
• Species: Homo sapiens
• Alignment Length: 927
• Identity: 326/927 - (35%)
• Similarity: 507/927 - (54%)
• Gaps: 124/927 - (13%)

  Fly    19 IFWPEFSSAQQQQQTVSLTEKIPLGAIFE------QGTDDVQSAFKYAM--LNHN---LNVSSRR 72
            :.|..:|.        ..|..:..|.|||      .|.:::  ||::|:  :|.|   |..::..
Human    23 LLWIGYSQ--------GTTHVLRFGGIFEYVESGPMGAEEL--AFRFAVNTINRNRTLLPNTTLT 77

  Fly    73 FELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKV 137
            ::.|.    ||..|:|:.|:..|:|.|.||.::.|.....|.:.:.|..|...:|.:...:..:|
Human    78 YDTQK----INLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQV 138

  Fly   138 LAPSSGLLDFAISMRPDY---HQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFR 199
               |.....|.:|:.||:   .:||:|.:|::.|:::..:||...||:|||::.:  .|.....|
Human   139 ---SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIK--APSRYNLR 198

  Fly   200 VQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRT--YHYLLS 262
            :::.:..|:...|...   |:::.|..:..::.||..|||..|:.|   .:.:|..|  |||:.:
Human   199 LKIRQLPADTKDAKPL---LKEMKRGKEFHVIFDCSHEMAAGILKQ---ALAMGMMTEYYHYIFT 257

  Fly   263 GLVMDNHWPSDV--VEFGAINITGFRIVDSNRRAVRDFHD--SRKRLEPSGQSQSQNAGGPNSLP 323
            .|.:   :..||  ..:..:|:|||||:::....|....:  |.:||:...:..|....|
Human   258 TLDL---FALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDG----- 314

  Fly   324 AISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSK 388
            .::..||||||||.|:..|    :::.|....|:                        |.||..|
Human   315 FMTTDAALMYDAVHVVSVA----VQQFPQMTVSS------------------------LQCNRHK 351

  Fly   389 GWVTPWEQGEKISRVLRKVEIDGLSGEIRFDE-DGRRINYTLHVVEMSVNSTLQQVAEWRDDAGL 452
                ||..|.:...::::...:||:|.|.|:: :|.|.::.|.|:.:. ...|:::..|...:||
Human   352 ----PWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLK-EEGLEKIGTWDPASGL 411

  Fly   453 LPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLAD 517
                  |...|.:...|:..|...|.:.||:::|||||:..|:  ..:.|.|||||||||.||..
Human   412 ------NMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKK--SDKPLYGNDRFEGYCIDLLR 468

  Fly   518 MLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKP 582
            .|:..||..||||||:||.|||::. |.|.|:|||.|||..:||:|::.:.||..||:|||||||
Human   469 ELSTILGFTYEIRLVEDGKYGAQDD-ANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532

  Fly   583 FMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQA 647
            ||||||||:.:||....|||||||||||.:||:.::|:|:|||.||:.:.||.||||........
Human   533 FMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNP 597

  Fly   648 DSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVW 712
            ||                      .|..|.||:|||||:.:.|.||||.::.|.:::.||...:|
Human   598 DS----------------------DVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIW 640

  Fly   713 WFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKM 777
            ||||:|:|||||||||||||||||.:||.:.:||..||.:.||.:..|:|..||::|:|..::||
Human   641 WFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKM 705

  Fly   778 WEYMNA-NQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVA 841
            |.:|:: .|...|.:.:|||:||..|  .||.|:||...|:|..| .|:..::|..||:||:||.
Human   706 WAFMSSRRQSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQR-NCNLTQIGGLIDSKGYGVG 767

  Fly   842 TPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGG 906
            ||:|||.|.::..|:|.|:|.|:|..::.||| ....|. ::|:...:.|.:.|:.||:.:|..|
Human   768 TPMGSPYRDKITIAILQLQEEGKLHMMKEKWW-RGNGCP-EEESKEASALGVQNIGGIFIVLAAG 830

  Fly   907 LLLAVIVAIMEFFCRNK 923
            |:|:|.||:.||..::|
Human   831 LVLSVFVAVGEFLYKSK 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	110/435 (25%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	193/402 (48%)
		Lig_chan	610..906	CDD:459656	122/296 (41%)
GRIK2	NP_068775.1	PBP1_iGluR_Kainate	37..414	CDD:380605	111/440 (25%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	193/398 (48%)