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Protein Alignment GluRIA and GRIK1

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	952	Identity:	326/952 - (34%)
Similarity:	514/952 - (53%)	Gaps:	146/952 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AYLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFE----QGTDDVQSAFKYAMLNHNLN-- 67
            |.|:|:|   ...|:           :..:.:.:|.|||    :..:..:.|||:|:.:.|.|
Human    20 ALLYFLC---YILPQ-----------TAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRT 70

  Fly    68 ---VSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFV 129
               .::..:::|.    ||..|:|:.||..|:|.:.||.::.|.....|...:.|..|..::|.:
Human    71 LMPNTTLTYDIQR----INLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHI 131

  Fly   130 -TPWFPEKVLAPSSGLLD-FAISMRPDY---HQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQ 189
             |.|     ..||....| |.|::.|||   .:||:|.:.||.|:::..:|:...||:|||::.:
Human   132 QTRW-----KHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIK 191

  Fly   190 ELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGR 254
              .|.....::: ::::.:.....:.|  |:::.:..:..::.||..|.|.||:.|   .:.:|.
Human   192 --APSRYNIKIK-IRQLPSGNKDAKPL--LKEMKKGKEFYVIFDCSHETAAEILKQ---ILFMGM 248

  Fly   255 RT--YHYLLSGL---VMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHD--SRKRLEPSGQSQ 312
            .|  |||..:.|   .:|    .::..:..:|:||||:::.:...|....:  |.:||:...:.:
Human   249 MTEYYHYFFTTLDLFALD----LELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPE 309

  Fly   313 SQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNE 377
            :....|     .::.:||||||||:::..|                    ||..|..:.::
Human   310 TGLLDG-----MMTTEAALMYDAVYMVAIA--------------------SHRASQLTVSS---- 345

  Fly   378 SSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDE-DGRRINYTLHVVEMSVNSTLQ 441
                |.|:..|    ||..|.:...::::...|||:|.|.|:: :|.|.::.|.::.:....|.:
Human   346 ----LQCHRHK----PWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEK 402

  Fly   442 QVAE--------------WRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLS 492
            ...|              |..::||      |...|::..|::..|...|.|.||:::|||||:.
Human   403 AAGEVSKHLYKVWKKIGIWNSNSGL------NMTDSNKDKSSNITDSLANRTLIVTTILEEPYVM 461

  Fly   493 LKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIR 557
            .::  ..:.|.|||||||||.||...|:..||..|:::||.||.|||:|.  .|.|:|||.|||.
Human   462 YRK--SDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQND--KGEWNGMVKELID 522

  Fly   558 KEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYV 622
            ..||:|::.:|||..||:|||||||||||||||:.:||....|||||||||||.:||:.|:|:.:
Human   523 HRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACL 587

  Fly   623 GVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYS 687
            |||.||:.:.||.||||........||                      .|..|.||:|||||:.
Human   588 GVSCVLFVIARFTPYEWYNPHPCNPDS----------------------DVVENNFTLLNSFWFG 630

  Fly   688 LAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDV 752
            :.|.||||.::.|.:::.||...:|||||:|:|||||||||||||||||.:||.:.:||..||.:
Human   631 VGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKI 695

  Fly   753 NYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHS-VHTYDEGIRRVRQSKGKYALLVESPKNE 816
            .||.:..|||..||::|:|..:.|||.:|::.|..: |...||||:||..:  .||||:||...|
Human   696 EYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTT--DYALLMESTSIE 758

  Fly   817 YVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNL 881
            ||..| .|:..::|..||:||:||.||||||.|.::..|:|.|:|.|:|..::.||| ....|.
Human   759 YVTQR-NCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWW-RGNGCP- 820

  Fly   882 DQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            :::....:.|.:.|:.||:.:|..||:|:|.|||.||..:::
Human   821 EEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSR 862

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.