Protein Alignment GluRIA and GRID2

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_011530195.2
• Gene: GRID2 / 2895
• HGNCID: 4576
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 958
• Identity: 236/958 - (24%)
• Similarity: 418/958 - (43%)
• Gaps: 190/958 - (19%)

  Fly    43 GAIFEQGTDDV-----------QSAFKYAMLNHNLNV-SSRRFELQAYVDVINTAD-AFKLSRLI 94
            |....||:.|:           |..|...|:.....| ::.|..|:.......||. |..|.:..
Human    30 GLYHVQGSSDLVTQVLWPSRVSQRVFCSVMVVVRSGVTAATRMPLRETRGTNTTASPATALPQKT 94

  Fly    95 CNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLA--PSSGL--------LDFAI 149
            |...::|:.:::.::...|..:|.|.::...:|.:   |.::..|  |.||.        .|:.:
Human    95 CELMNQGILALVSSIGCTSAGSLQSLADAMHIPHL---FIQRSTAGTPRSGCGLTRSNRNDDYTL 156

  Fly   150 SMRPD--YHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIAN--VT 210
            |:||.  .|..|:..:..|.||..|..|||...:..:|:...::........:|.|:...|  :|
Human   157 SVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMIT 221

  Fly   211 MAIEFLHTLEDLGRF--SKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLV-MDNHW-- 270
            ...:.:. :|:|.|:  :.:|.:|......||..|.:.|.             :.|| .|.||
Human   222 TLFDTMR-IEELNRYRDTLRRAILVMNPATAKSFITEVVE-------------TNLVAFDCHWII 272

  Fly   271 ------PSDVVEFGAINITGFRIV--------DSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNS 321
                  ..||.|....:|....|:        :.::|..|..|.....|.......:||
Human   273 INEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQN------ 331

  Fly   322 LPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDC-- 384
               :......:||.|.:|..||::.|.           .|:.|             |.|.|.|
Human   332 ---MEISNLYIYDTVLLLANAFHKKLE-----------DRKWH-------------SMASLSCIR 369

  Fly   385 NTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVV----------------- 432
            ..||    ||:.|..:...::|..:.||:||:.|.|:|...|....::
Human   370 KNSK----PWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKNER 430

  Fly   433 ---EMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYI---VSSLLEEPYL 491
               :.|......|:..|....||             :.|.:....:.|...:   |.::||||::
Human   431 IRPQGSTGKIWPQLGCWNPVTGL-------------NGSLTDKKLENNMRGVVLRVVTVLEEPFV 482

  Fly   492 SLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELI 556
            .:.:...|:.    .:::|:..|:.|.|:..||..|||.:..|..||:..:  .|.|:|:||||:
Human   483 MVSENVLGKP----KKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQE--DGTWNGLVGELV 541

  Fly   557 RKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSY 621
            .|.|||.|||:|||.:||.|:||:..:|...:.::::: .::|..:|:.|.|....:|..:..:.
Human   542 FKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRR-AEKTVDMFACLAPFDLSLWACIAGTV 605

  Fly   622 VGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWY 686
            :.|..::|.:      .|            ..||.:..|:..|.             |:.||.|:
Human   606 LLVGLLVYLL------NW------------LNPPRLQMGSMTST-------------TLYNSMWF 639

  Fly   687 SLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTD 751
            ...:|:|||.::...::|.|:....||.|.:|:|||||||||||||:.|:.:.|::.:||:.||:
Human   640 VYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTE 704

  Fly   752 VNYGTLLYGSTWEFFRRSQI------GLHNKMWEYMNAN--QHHSVHTYDEGIRRVRQSKGKYAL 808
            :.|||:|..:.:|..|...:      .::::||..:|.:  ..::|.....||::|:.  |.||.
Human   705 IPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKY--GNYAF 767

  Fly   809 LVESPKNEYVNAR-PPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKW 872
            :.::...|||... |.|....:|..:..:|:|:|...|||.|...::.:|.|::||::..:::||
Human   768 VWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKW 832

  Fly   873 WFDKTECNLDQETSTPNE---LSLSNVAGIYYILIGGLLLAVIVAIME 917
            |....:|:|.....|..:   |.:.:.||::.||..|::|:..:|::|
Human   833 WPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLE 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	100/480 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	123/413 (30%)
		Lig_chan	610..906	CDD:459656	85/307 (28%)
GRID2	XP_011530195.2	Periplasmic_Binding_Protein_type1	92..457	CDD:471960	86/431 (20%)
		PBP2_iGluR_delta_2	468..834	CDD:270449	121/405 (30%)