DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and GRID1

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	940	Identity:	262/940 - (27%)
Similarity:	429/940 - (45%)	Gaps:	150/940 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAY-VDVINTADAFKLSRLICNQFSRGVY 103
            |.:|||||:........|:.|:.:.:||....:.|...| :.||...:.|:..:..|:..::|:.
Human    24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGIL 88

  Fly   104 SMLGAVSPDSFDTLHSYSNTFQMP--FV--TPWFPEKV---LAPSSGLLDFAISMRPD--YHQAI 159
            :::.:....|.:.|.|.::...:|  ||  .|....:.   |.||.....:.::.||.  .:..:
Human    89 ALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVM 153

  Fly   160 IDTIQYYGWQSIIYLYDSHDGLLRLQQ-IYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLG 223
            :..:....||..:..|||...:..||. :.|..:.|.:....::.|.|::|..::......|:|.
Human   154 LRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELN 218

  Fly   224 RF--SKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHW---------PS--DVV 275
            |:  :.:|.:|....:.|...|.:.| :..|..:           |:||         |.  |:|
Human   219 RYRDTLRRAILLLSPQGAHSFINEAV-ETNLASK-----------DSHWVFVNEEISDPEILDLV 271

  Fly   276 EFGAINITGFRIV----DSNRRAVRDFHDSRKRL-EPSGQSQSQNAGGPNSLPAISAQAALMYDA 335
            ......:|..|.:    ..|::..|:.|.....| :|.          ...|..:......:||:
Human   272 HSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQ----------EGYLQMLQISNLYLYDS 326

  Fly   336 VFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDC--NTSKGWVTPWEQGE 398
            |.:|..||:|.|.           .|:.|             |.|.|:|  .::|    ||..|.
Human   327 VLMLANAFHRKLE-----------DRKWH-------------SMASLNCIRKSTK----PWNGGR 363

  Fly   399 KISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNST----LQQVAEWRDDAGLLPLHSHN 459
            .:...::|..|.||:|.:.|.||.........::..:.:.|    ::::|.|..:.||      |
Human   364 SMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGL------N 422

  Fly   460 YASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGN-DRFEGYCKDLADMLAAQL 523
            .:...|    ..|...:..|..|.::||||::.:     .|:::|. .|::|:..|:.|.||..|
Human   423 GSLQER----PMGSRLQGLTLKVVTVLEEPFVMV-----AENILGQPKRYKGFSIDVLDALAKAL 478

  Fly   524 GIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGI 588
            |.||||....||.||  :|.....|:||:||||.|.||:||||:|||.|||.|:||||.:|...:
Human   479 GFKYEIYQAPDGRYG--HQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSV 541

  Fly   589 SIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQ 653
            .|:|||| ::...:||...|....:|..:..:...|..:::.:.|        ::..:|.|.||
Human   542 GILIKKP-EEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNR--------IQAVRAQSAAQ- 596

  Fly   654 PPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTII 718
                              |.|....|:.::.|....||:|||.:.:..|:|.||....||.||:|
Human   597 ------------------PRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLI 643

  Fly   719 LISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRR------SQIGLHNKM 777
            :.|||||||||||||.||..||:|.:||:.|.:::|||:...:.:|:||.      .|.....::
Human   644 VCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAEL 708

  Fly   778 WEYM--NANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVN-ARPPCDTMKVGRNIDTKGFG 839
            |..:  |....:.|.:..||||:.:  ||.||.|.:....||.. ....|....:|.:|.:||:|
Human   709 WRTISKNGGADNCVSSPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYG 771

  Fly   840 VATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTP---NELSLSNVAGIYY 901
            :|...|||.|...::.:|.|::.|:|..::.|||.....|:|....|..   ..|.|.:.||::.
Human   772 IALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFC 836

  Fly   902 ILIGGLLLAVIVAIMEFF-----CRNKTPQ 926
            ||..|||||.:||.:|.:     |..:||:
Human   837 ILAIGLLLACLVAALELWWNSNRCHQETPK 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	93/446 (21%)
		ANF_receptor	53..434	CDD:279440	84/411 (20%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	144/411 (35%)
		Lig_chan	612..907	CDD:278489	94/306 (31%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		98/471 (21%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	94/453 (21%)
		ANF_receptor	41..400	CDD:279440	84/408 (21%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	143/406 (35%)
		Lig_chan	564..841	CDD:278489	94/305 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740