Protein Alignment GluRIA and GRIA4

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_000820.4
• Gene: GRIA4 / 2893
• HGNCID: 4574
• Length: 902
• Species: Homo sapiens
• Alignment Length: 951
• Identity: 388/951 - (40%)
• Similarity: 545/951 - (57%)
• Gaps: 108/951 - (11%)

  Fly    40 IPLGAIFEQGTDDVQSAFKYAMLNHNL--NVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 102
            :.:|.:|.:.||...:||:.|:..||.  |.|...|.|..:||.|.||::|.::...|:|:||||
Human    27 VQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGV 91

  Fly   103 YSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYG 167
            :::.|.....|..||.|:.:...:..:||.|      |:.|...|.:.:||....|::..:.:|.
Human    92 FAIFGLYDKRSVHTLTSFCSALHISLITPSF------PTEGESQFVLQLRPSLRGALLSLLDHYE 150

  Fly   168 WQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVL 232
            |...::|||:..|...||.|.:  |.|...:.|..: .:.|.. .:.:...||:|.|..:|:.|:
Human   151 WNCFVFLYDTDRGYSILQAIME--KAGQNGWHVSAI-CVENFN-DVSYRQLLEELDRRQEKKFVI 211

  Fly   233 DCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAV 295
            ||..|..:.|:.|.|   .:|:  :.|||:::.|...:......:..|| |:|||::||.|...|
Human   212 DCEIERLQNILEQIV---SVGKHVKGYHYIIANLGFKDISLERFIHGGA-NVTGFQLVDFNTPMV 272

  Fly   296 RDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQ 360
            ....|..|:|:      .:...|..:.|..:  :||.||.|.|:.|.|..:.|:|.|      :.
Human   273 IKLMDRWKKLD------QREYPGSETPPKYT--SALTYDGVLVMAETFRSLRRQKID------IS 323

  Fly   361 RRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRI 425
            ||.:.|                ||..:.  ..||.||..:.|.|::|.|.||:|.::||..|||:
Human   324 RRGNAG----------------DCLANP--AAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRV 370

  Fly   426 NYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPY 490
            |||:.|.|:. ::..::|..|.|...|:.:.......:..:|.       .|.|.:|::::|.||
Human   371 NYTMDVFELK-STGPRKVGYWNDMDKLVLIQDVPTLGNDTAAI-------ENRTVVVTTIMESPY 427

  Fly   491 LSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGEL 555
            :..|:  ..|...|||::||||.|||..:|..:||||:|.:|.||.|||.:.... .|:||||||
Human   428 VMYKK--NHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTK-IWNGMVGEL 489

  Fly   556 IRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILS 620
            :..:|:|||:.:|||..||.|||||||||:||||||||||.|..|||||||:||:.|||:.::.:
Human   490 VYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFA 554

  Fly   621 YVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFW 685
            |:|||.||:.|:||.||||.         |.:...|..|.:          ..|||||.:.||.|
Human   555 YIGVSVVLFLVSRFSPYEWH---------TEEPEDGKEGPS----------DQPPNEFGIFNSLW 600

  Fly   686 YSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQT 750
            :||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||:||::.|||..||
Human   601 FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQT 665

  Fly   751 DVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLVESPK 814
            ::.||||..|||.||||||:|.::.|||.|| :|.......|..||:.|||:||||:|.|:||..
Human   666 EIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTM 730

  Fly   815 NEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTEC 879
            |||:..|.||||||||.|:|:||:|||||.||.||..:|.|||.|.|.|.|.:::||||:||.||
Human   731 NEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGEC 795

  Fly   880 NLDQETS--TPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFC------------------RNKT 924
            ......|  ..:.||||||||::|||:|||.||::||::| ||                  |||.
Human   796 GPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIE-FCYKSRAEAKRMKLTFSEAIRNKA 859

  Fly   925 PQLKSPGSNGSAGGV-----PGMLASSTYQRDSLSDAIMHS 960
             :|...||.|..|.|     |..:.:.|..|.|...|::.|
Human   860 -RLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIAS 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	125/418 (30%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	223/402 (55%)
		Lig_chan	610..906	CDD:459656	162/298 (54%)
GRIA4	NP_000820.4	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	125/418 (30%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	223/402 (55%)