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Protein Alignment GluRIA and GRIA3

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	896	Identity:	382/896 - (42%)
Similarity:	538/896 - (60%)	Gaps:	90/896 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IPLGAIFEQGTDDVQSAFKYA--MLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 102
            |.:|.:|.:.|....|||::|  :.|.|.|.:.:.|.|..:||.::::::|.::...|:||||||
Human    34 ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGV 98

  Fly   103 YSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYG 167
            |::.|.....|.:||.|:.......||||.|      |:...:.|.|.|||....||:..:.:|.
Human    99 YAIFGFYDQMSMNTLTSFCGALHTSFVTPSF------PTDADVQFVIQMRPALKGAILSLLGHYK 157

  Fly   168 WQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVL 232
            |:..:||||:..|...||.|.:.....|.....:.|..|.:|.   ||...:|::.|..:||.::
Human   158 WEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQ---EFRRIIEEMDRRQEKRYLI 219

  Fly   233 DCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDV----VEFGAINITGFRIVDSN 291
            ||..|....|:.|.|   .||:  |.|||:|:.|..     :|:    |..|..|||||:||::.
Human   220 DCEVERINTILEQVV---ILGKHSRGYHYMLANLGF-----TDILLERVMHGGANITGFQIVNNE 276

  Fly   292 RRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRS 356
            ...|:.|.....||:.....:::||       .:...:||.:||:.|:.|||..:.|::.|
Human   277 NPMVQQFIQRWVRLDEREFPEAKNA-------PLKYTSALTHDAILVIAEAFRYLRRQRVD---- 330

  Fly   357 NHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDED 421
              :.||...|                ||..:.  ..||.||..|.|.|:.|::.|::|.|:||..
Human   331 --VSRRGSAG----------------DCLANP--AVPWSQGIDIERALKMVQVQGMTGNIQFDTY 375

  Fly   422 GRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLL 486
            |||.|||:.|.||.|:.: ::...|.:....:|......::.|.|:        .|.|.:|:::|
Human   376 GRRTNYTIDVYEMKVSGS-RKAGYWNEYERFVPFSDQQISNDSASS--------ENRTIVVTTIL 431

  Fly   487 EEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGM 551
            |.||:..|:  ..|.|.||:|:||||.|||..:|..:.|||::.:|.||.|||.:.... .|:||
Human   432 ESPYVMYKK--NHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETK-IWNGM 493

  Fly   552 VGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWIS 616
            ||||:...||||::.:|||..||.|||||||||:||||||||||.|..|||||||:||:.|||:.
Human   494 VGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMC 558

  Fly   617 VILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTML 681
            ::.:|:|||.||:.|:||.||||.:      :...::|         .:||:  ||.|||||.:.
Human   559 IVFAYIGVSVVLFLVSRFSPYEWHL------EDNNEEP---------RDPQS--PPDPPNEFGIF 606

  Fly   682 NSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDL 746
            ||.|:||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||:||::.|||
Human   607 NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 671

  Fly   747 TMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLV 810
            ..||::.||||..|||.||||||:|.::.|||.|| :|.......|..:|:.|||:||||:|.|:
Human   672 AKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLL 736

  Fly   811 ESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFD 875
            ||..|||:..|.||||||||.|:|:||:|||||.||.||..:|.|||.|.|.|.|.:::||||:|
Human   737 ESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYD 801

  Fly   876 KTECNL---DQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923
            |.||..   |.:..| :.||||||||::|||:|||.||::||::||..:::
Human   802 KGECGSGGGDSKDKT-SALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSR 851

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.