Protein Alignment GluRIA and Ir41a

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_995744.4
• Gene: Ir41a / 2768714
• FlyBaseID: FBgn0040849
• Length: 648
• Species: Drosophila melanogaster
• Alignment Length: 729
• Identity: 144/729 - (19%)
• Similarity: 245/729 - (33%)
• Gaps: 216/729 - (29%)

  Fly   272 SDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAV 336
            ||.:.|..|||..|.  |:....:.|....:|.|      |:::......:..|.....:.:...
  Fly    40 SDYISFVGINIKSFD--DNGGHYIIDTGLKKKEL------QNKHLFLDELVIKIIISIEVTHCET 96

  Fly   337 FVL--------VEAFNR-----ILRKKPDQFRSNHL-----QRRSHGGSSSSS---ATGTNESSA 380
            ||:        |.|||:     |.|...::|...|:     :.|:|......:   ....:.|::
  Fly    97 FVVFDKDIDRFVNAFNKASVYSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDHSSAS 161

  Fly   381 LLDCNTSKGWVTPWEQGEKISRVLRKVEIDG-LSGEIRF------------DEDGRRI------- 425
            ..|..|:| :|     |.|.....:.:.:|. |:.|.||            :..||.:
  Fly   162 SFDIKTNK-FV-----GRKAENPSQMILVDRYLASEQRFQFGKSLFADKLNNLQGREVIIAGFDY 220

  Fly   426 -NYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEP 489
             .||:....||.|:         .|.|:                  :|:.|..:.||..:   |.
  Fly   221 PPYTVIKHNMSTNA---------QDMGV------------------SGESDFKNVYIDGT---ET 255

  Fly   490 YLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGE 554
            .:.|                .:|:        |.....:|......::|  ..|.....||.:|.
  Fly   256 RIVL----------------NFCE--------QFNCTIQIDSSAANDWG--KVYPNMSGDGALGM 294

  Fly   555 LIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVIL 619
            ||.::|||.|.||....|....:|.|...:..||:.::..|::.|..... |.|..:.:|.:::|
  Fly   295 LINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLP-LEPFKETLWAAILL 358

  Fly   620 SYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSF 684
            ...                        |::|     |:: .|..||...:|.|.....:....||
  Fly   359 CLC------------------------AEAT-----GLV-LAYKSEQALYVLPGYREGWWTCTSF 393

  Fly   685 WY--SLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLT 747
            ..  :...|:.|..:....|:..|:.....:...:|:.|.|...||:.||:..|.....|...|.
  Fly   394 GVCTTFKLFISQSGNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTVTRLR 458

  Fly   748 MQTDVNYGTLLYGSTWEFFRRSQIGLHNKMW--------EYMNANQHHSVHTY--DEGIRRVRQS 802
                              |.|.|...:::.|        |.:..:..::.|.|  ||.:|..:..
  Fly   459 ------------------FHRLQWAANSEAWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQ 505

  Fly   803 KGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKG--------------FGVA-TPIGSPLRKRL 852
            ..:....||         |.|.....:|..:..:.              :.|| .|...||..:|
  Fly   506 HMRIGFTVE---------RLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKL 561

  Fly   853 NEAVLTLKENGELLRIRNKWW-FDKTECNLD-------QETST------PNELSLSNVAGIYYIL 903
            |..:.:...:|     .:|:| :.....||:       |||.|      |..|.:||.||...:.
  Fly   562 NTLIYSWHSSG-----FDKYWEYRVVADNLNLKIQQQVQETMTGTKDIGPVPLGMSNFAGFIIVW 621

  Fly   904 IGGLLLAVIVAIME 917
            |.|..:|.:..::|
  Fly   622 ILGSAIATLTFLLE 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	46/225 (20%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	80/429 (19%)
		Lig_chan	610..906	CDD:459656	64/336 (19%)
Ir41a	NP_995744.4	None