DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grin2d

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_038951440.1	Gene:	Grin2d / 24412	RGDID:	2740	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	955	Identity:	207/955 - (21%)
Similarity:	346/955 - (36%)	Gaps:	259/955 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 VSSRRFELQAYVDVINTADAFKLSRLICNQFS----RGVY----SMLGAVSPDSFDTLHSYSNTF 124
            |.|...:::....|:|.:|...|...:|:..|    .||.    |...||:|    .|...|...
  Rat    74 VRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAP----ILDFLSAQT 134

  Fly   125 QMPFV----------TPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHD 179
            .:|.|          ||  .||    .|..|....|..... |.|.:.::.|.|.|.:.:
  Rat   135 SLPIVAVHGGAALVLTP--KEK----GSTFLQLGSSTEQQL-QVIFEVLEEYDWTSFVAV----- 187

  Fly   180 GLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIV 244
                     ....||:..|              :.::..|.|
  Rat   188 ---------TTRAPGHRAF--------------LSYIEVLTD----------------------- 206

  Fly   245 QHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAV----RDFHDSRKRL 305
                             ..||...|..:..::.||    |..::.:..|:|    |....:|:..
  Rat   207 -----------------GSLVGWEHRGALTLDPGA----GEAVLGAQLRSVSAQIRLLFCAREEA 250

  Fly   306 EP------------------------SGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRI 346
            ||                        :|...|...|.|..||..|...|    .:|.:..|..|
  Rat   251 EPVFRAAEEAGLTGPGYVWFMVGPQLAGGGGSGVPGEPLLLPGGSPLPA----GLFAVRSAGWR- 310

  Fly   347 LRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALL-----------DCNTSKGWVTPWEQGEKI 400
                      :.|.||...|    .|.....:.|||           ||.|.    ....:||.:
  Rat   311 ----------DDLARRVAAG----VAVVARGAQALLRDYGFLPELGHDCRTQ----NRTHRGESL 357

  Fly   401 SRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSR 465
            .|....:..|  :.:..|:|||..:|.:|.|:.::.:.|.:.|..|......|     .|...||
  Rat   358 HRYFMNITWD--NRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRL-----KYPLWSR 415

  Fly   466 SASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGN------------DR----------- 507
            .........|..| ..|::|.|.|::.::.   .:.:.|.            :|
  Rat   416 YGRFLQPVDDTQH-LTVATLEERPFVIVEP---ADPISGTCIRDSVPCRSQLNRTHSPPPDAPRP 476

  Fly   508 ----FEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMT 568
                .:|:|.|:...||..:|..|::.||.:|.:|.:   ..|.|:||:||:..:.||:||.::|
  Rat   477 EKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKK---IDGVWNGMIGEVFYQRADMAIGSLT 538

  Fly   569 ITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFL-----------NPLSQEIWISVILSYV 622
            |..||..::|||.||:..|||:|:.:. ..|....:||           .|.|..:|:.:.:..:
  Rat   539 INEERSEIVDFSVPFVETGISVMVARS-NGTVSPSAFLAFAWLTPPMSPEPYSPAVWVMMFVMCL 602

  Fly   623 GVSFVLYFVTRF-PPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWY 686
            .|..|..|:..: .|..:.     ::.:|.::|    ||:|               ||:..|.|.
  Rat   603 TVVAVTVFIFEYLSPVGYN-----RSLATGKRP----GGST---------------FTIGKSIWL 643

  Fly   687 SLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQ- 749
            ..|........: .|.....:|...||.||.:|.::|||||||||:..|..|..:....|...|
  Rat   644 LWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQR 708

  Fly   750 -----TDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALL 809
                 ..:.:||:..|||.:..|.:...:|:.|..|   ||..    .:|.:.:::..|....:.
  Rat   709 PQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRY---NQPR----VEEALTQLKAGKLDAFIY 766

  Fly   810 VESPKNEYVNARPPCD--TMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKW 872
            ..:..|........|.  |:..|:...|.|:|:|...||..::.::.|:|....:.|:..:...|
  Rat   767 DAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLW 831

  Fly   873 WFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIME 917
            .  ...|:.|:.....::|.:.|:||::|:|:..:.|:::|...|
  Rat   832 L--SGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWE 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	83/441 (19%)
		ANF_receptor	53..434	CDD:279440	80/422 (19%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	108/449 (24%)
		Lig_chan	612..907	CDD:278489	70/304 (23%)
Grin2d	XP_038951440.1	PBP1_iGluR_NMDA_NR2	46..410	CDD:380601	84/448 (19%)
		PBP2_iGluR_NMDA_Nr2	427..838	CDD:270436	109/451 (24%)
		PHA03307	<1125..>1312	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810