Protein Alignment GluRIA and Grin2c

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_017452477.1
• Gene: Grin2c / 24411
• RGDID: 2739
• Length: 1250
• Species: Rattus norvegicus
• Alignment Length: 1091
• Identity: 225/1091 - (20%)
• Similarity: 387/1091 - (35%)
• Gaps: 295/1091 - (27%)

  Fly    21 WPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHN-LNVSSRRFELQAYVDVINT 84
            |....:.|.:|   ::|..:..|:     :..:|:..:..:.:.| |::.   .|:|.....:|.
  Rat    31 WARLGAGQGEQ---AVTVAVVFGS-----SGPLQTQARTRLTSQNFLDLP---LEIQPLTVGVNN 84

  Fly    85 ADAFKLSRLICNQFSRGVYSMLGAVSPDSFDT------LHSYSNTFQMPF----------VTPWF 133
            .:...:...||...  |...:.|.|..|:.||      |...|:...:|.          :||
  Rat    85 TNPSSILTQICGLL--GAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTP-- 145

  Fly   134 PEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDG---LLR------------ 183
                ..|.|..|...:|:.... |.:...::.|.|.:...:...|.|   .|.
  Rat   146 ----KEPGSAFLQLGVSLEQQL-QVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLS 205

  Fly   184 ---LQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQ 245
               |..:..||.||....|.|.:.|..:..:.:.:                  |..|.|:.:..:
  Rat   206 WRLLDVLTLELGPGGPRARTQRLLRQVDAPVLVAY------------------CSREEAEVLFAE 252

  Fly   246 HVRDIKLGRRTYHYLLSGLVMDNH-WPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPS- 308
            ..:             :|||...| |                                  |.|:
  Rat   253 AAQ-------------AGLVGPGHVW----------------------------------LVPNL 270

  Fly   309 --GQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSN--------HLQRRS 363
              |.:.:..|..|..|             :.|:.|::...||:|   .|..        |..||.
  Rat   271 ALGSTDAPPAAFPVGL-------------ISVVTESWRLSLRQK---VRDGVAILALGAHSYRRQ 319

  Fly   364 HGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYT 428
            :|...:.:.          ||.:..|.|:|  ..|...|.|..|..:|  .:..|...|..:..|
  Rat   320 YGTLPAPAG----------DCRSHPGPVSP--AREAFYRHLLNVTWEG--RDFSFSPGGYLVRPT 370

  Fly   429 LHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSL 493
            :.|:.::.:...:.|..|  |.|:|.:   .|....|.:::.....|..| ..|::|.|.|::.:
  Rat   371 MVVIALNRHRLWEMVGRW--DHGVLYM---KYPVWPRYSTSLQPVVDSRH-LTVATLEERPFVIV 429

  Fly   494 KQYTYGES----------LVGNDRF-------------EGYCKDLADMLAAQLGIKYEIRLVQDG 535
            :....|..          ...|..|             :|:|.|:...||..:...|::.||.:|
  Rat   430 ESPDPGTGGCVPNTVPCRRQSNHTFSSGDLTPYTKLCCKGFCIDILKKLAKVVKFSYDLYLVTNG 494

  Fly   536 NYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTP 600
            .:|   :...|.|:||:||:..|.||:||.::||..||..:||||.||:..|||:|:.:. ..|.
  Rat   495 KHG---KRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRS-NGTV 555

  Fly   601 GVFSFLNPLSQEIWISV-ILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLS 664
            ...:||.|.|..:|:.: ::....|:..::....|.|..:.     |..:..::|.|
  Rat   556 SPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYN-----QNLTKGKKPGG-------- 607

  Fly   665 EPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTANLA 728
                      |: ||:..|.|...|........| .|.....:|...||.||.:|.::|||||||
  Rat   608 ----------PS-FTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLA 661

  Fly   729 AFLTVERMVAPIKTPEDLTMQ------TDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHH 787
            ||:..|:.:..:....|...|      ....:||:..|||....|.:...:|..|.::...:...
  Rat   662 AFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVED 726

  Fly   788 SVHT----------YDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVAT 842
            ::.:          ||..:......|.:...||               |:..|:...|.|:|:|.
  Rat   727 ALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLV---------------TIGSGKVFATTGYGIAM 776

  Fly   843 PIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGL 907
            ...|..::.::.|:|.|..:||..::...|.  ...|..::.....::|.:.|:||::|:|:..:
  Rat   777 QKDSHWKRAIDLALLQLLGDGETQKLETVWL--SGICQNEKNEVMSSKLDIDNMAGVFYMLLVAM 839

  Fly   908 LLAVIVAIME---------------------------FFCRNKTPQLKSPGSNGSAGGVPGMLAS 945
            .||::|...|                           :.|.|....|.||....|    |.:.|.
  Rat   840 GLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIYSCFNGVQSLPSPARPPS----PDLTAD 900

  Fly   946 STY---------QRDSLSDAIMHSQAKLAMQASSEY-DERLVGVELASNVR 986
            |..         .||.::.|.:.|....|.:....: :.|.|....||..|
  Rat   901 SAQANVLKMLQAARDMVNTADVSSSLDRATRTIENWGNNRRVPAPTASGPR 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	81/461 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	107/442 (24%)
		Lig_chan	610..906	CDD:459656	67/313 (21%)
Grin2c	XP_017452477.1	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601	83/475 (17%)
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	108/445 (24%)
		NMDAR2_C	850..>925	CDD:463148	12/78 (15%)