Protein Alignment GluRIA and Grin2b

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_036706.1
• Gene: Grin2b / 24410
• RGDID: 2738
• Length: 1482
• Species: Rattus norvegicus
• Alignment Length: 1009
• Identity: 217/1009 - (21%)
• Similarity: 388/1009 - (38%)
• Gaps: 230/1009 - (22%)

  Fly    15 CASSIFW-------PEFSSAQQQQQTVSLTEKIPLG-AIFEQGTDDVQSAFKYAMLN---HNLNV 68
            |.|..||       ...|.|:.|:...|      :| |:...||.| :.|.|.|...   |:|:|
  Rat     7 CCSPKFWLVLAVLAVSGSKARSQKSPPS------IGIAVILVGTSD-EVAIKDAHEKDDFHHLSV 64

  Fly    69 SSRRFELQAYVDVINTADAFKLSRLICNQFS-RGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPW 132
            .. |.||.|    :|..|...:...||:..| |.:..::.|...|. :.:....:......:||.
  Rat    65 VP-RVELVA----MNETDPKSIITRICDLMSDRKIQGVVFADDTDQ-EAIAQILDFISAQTLTPI 123

  Fly   133 F-----PEKVLA---PSSGLLDFAISMRPDYHQA--IIDTIQYYGWQSIIYLYDSHDGLLRLQQI 187
            .     ...::|   .||....|..|:.   .||  :::.::.|.|    |::          .|
  Rat   124 LGIHGGSSMIMADKDESSMFFQFGPSIE---QQASVMLNIMEEYDW----YIF----------SI 171

  Fly   188 YQELKPGNETFRVQMVKRIANVTMAIEFLHTL--------------EDLGRFSKKRIVLDCPAEM 238
            .....||.:.|..::...|.|..:..|....|              ..|.:.....|:|.|..|.
  Rat   172 VTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEE 236

  Fly   239 AKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRK 303
            | ..|.:....:.|....|.:::..||
  Rat   237 A-TYIFEVANSVGLTGYGYTWIVPSLV-------------------------------------- 262

  Fly   304 RLEPSGQSQSQNAGGPNSLPAIS------AQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRR 362
                :|.:.:..:..|..|.::|      ...|.:.|.:.::..|            .|:.|...
  Rat   263 ----AGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIAIITTA------------ASDMLSEH 311

  Fly   363 SHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINY 427
            |......||...|:|....              |...::|.|..|..:|.:  :.|.|||.:::.
  Rat   312 SFIPEPKSSCYNTHEKRIY--------------QSNMLNRYLINVTFEGRN--LSFSEDGYQMHP 360

  Fly   428 TLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLS 492
            .|.::.::.....::|.:|:|.:    |....|...  .....|.:.:.:|..|| :|.|.|::.
  Rat   361 KLVIILLNKERKWERVGKWKDKS----LQMKYYVWP--RMCPETEEQEDDHLSIV-TLEEAPFVI 418

  Fly   493 LKQ------------YTYGESLVGNDRFE-----------GYCKDLADMLAAQLGIKYEIRLVQD 534
            ::.            ....:.::..::.:           |:|.|:...::..:...|::.||.:
  Rat   419 VESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN 483

  Fly   535 GNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQT 599
            |.:|.:   ..|.|:||:||::.|.|.:|:.::||..||..|:|||.||:..|||:|:.:. ..|
  Rat   484 GKHGKK---INGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRS-NGT 544

  Fly   600 PGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTR-FPPYEWRIVRRPQADSTAQQPPGIIGGATL 663
            ....:||.|.|.::|:.:.:..:.||.|..||.. |.|..:   .|..||  .::|.|
  Rat   545 VSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY---NRCLAD--GREPGG------- 597

  Fly   664 SEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTANL 727
                       |: ||:..:.|............: .|.....:|..:||.||.:|.::||||||
  Rat   598 -----------PS-FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANL 650

  Fly   728 AAFLTVERMVAPIKTPEDLTMQ------TDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQH 786
            |||:..|..|..:....|...|      ....:||:..|||....|.:...:|..|.::   ||
  Rat   651 AAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKF---NQ- 711

  Fly   787 HSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPP-CD--TMKVGRNIDTKGFGVATPIGSPL 848
               ...|:.:..::..| ..|.:.::....|:..|.. |.  |:..|:...:.|:|:|....|..
  Rat   712 ---RGVDDALLSLKTGK-LDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGW 772

  Fly   849 RKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIV 913
            :::::.|:|.|..:||:..:...|.  ...|:.::.....::|.:.|:||::|:|...:.|::|.
  Rat   773 KRQVDLAILQLFGDGEMEELEALWL--TGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLIT 835

  Fly   914 AIME--FFCRNKTPQLKSPGSNGSAGGVPGMLAS 945
            .|.|  |:.:.:...:      |...|.|||:.|
  Rat   836 FICEHLFYWQFRHCFM------GVCSGKPGMVFS 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	81/449 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	107/435 (25%)
		Lig_chan	610..906	CDD:459656	73/306 (24%)
Grin2b	NP_036706.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	83/459 (18%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	108/438 (25%)
		Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489	604..623		1/18 (6%)
		NMDAR2_C	840..1482	CDD:463148	7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1269..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding	1480..1482