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Protein Alignment GluRIA and Grin2b

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_036706.1	Gene:	Grin2b / 24410	RGDID:	2738	Length:	1482	Species:	Rattus norvegicus

Alignment Length:	1009	Identity:	217/1009 - (21%)
Similarity:	388/1009 - (38%)	Gaps:	230/1009 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CASSIFW-------PEFSSAQQQQQTVSLTEKIPLG-AIFEQGTDDVQSAFKYAMLN---HNLNV 68
            |.|..||       ...|.|:.|:...|      :| |:...||.| :.|.|.|...   |:|:|
  Rat     7 CCSPKFWLVLAVLAVSGSKARSQKSPPS------IGIAVILVGTSD-EVAIKDAHEKDDFHHLSV 64

  Fly    69 SSRRFELQAYVDVINTADAFKLSRLICNQFS-RGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPW 132
            .. |.||.|    :|..|...:...||:..| |.:..::.|...|. :.:....:......:||.
  Rat    65 VP-RVELVA----MNETDPKSIITRICDLMSDRKIQGVVFADDTDQ-EAIAQILDFISAQTLTPI 123

  Fly   133 F-----PEKVLA---PSSGLLDFAISMRPDYHQA--IIDTIQYYGWQSIIYLYDSHDGLLRLQQI 187
            .     ...::|   .||....|..|:.   .||  :::.::.|.|    |::          .|
  Rat   124 LGIHGGSSMIMADKDESSMFFQFGPSIE---QQASVMLNIMEEYDW----YIF----------SI 171

  Fly   188 YQELKPGNETFRVQMVKRIANVTMAIEFLHTL--------------EDLGRFSKKRIVLDCPAEM 238
            .....||.:.|..::...|.|..:..|....|              ..|.:.....|:|.|..|.
  Rat   172 VTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEE 236

  Fly   239 AKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRK 303
            | ..|.:....:.|....|.:::..||
  Rat   237 A-TYIFEVANSVGLTGYGYTWIVPSLV-------------------------------------- 262

  Fly   304 RLEPSGQSQSQNAGGPNSLPAIS------AQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRR 362
                :|.:.:..:..|..|.::|      ...|.:.|.:.::..|            .|:.|...
  Rat   263 ----AGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIAIITTA------------ASDMLSEH 311

  Fly   363 SHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINY 427
            |......||...|:|....              |...::|.|..|..:|.:  :.|.|||.:::.
  Rat   312 SFIPEPKSSCYNTHEKRIY--------------QSNMLNRYLINVTFEGRN--LSFSEDGYQMHP 360

  Fly   428 TLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLS 492
            .|.::.::.....::|.:|:|.:    |....|...  .....|.:.:.:|..|| :|.|.|::.
  Rat   361 KLVIILLNKERKWERVGKWKDKS----LQMKYYVWP--RMCPETEEQEDDHLSIV-TLEEAPFVI 418

  Fly   493 LKQ------------YTYGESLVGNDRFE-----------GYCKDLADMLAAQLGIKYEIRLVQD 534
            ::.            ....:.::..::.:           |:|.|:...::..:...|::.||.:
  Rat   419 VESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN 483

  Fly   535 GNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQT 599
            |.:|.:   ..|.|:||:||::.|.|.:|:.::||..||..|:|||.||:..|||:|:.:. ..|
  Rat   484 GKHGKK---INGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRS-NGT 544

  Fly   600 PGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTR-FPPYEWRIVRRPQADSTAQQPPGIIGGATL 663
            ....:||.|.|.::|:.:.:..:.||.|..||.. |.|..:   .|..||  .::|.|
  Rat   545 VSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY---NRCLAD--GREPGG------- 597

  Fly   664 SEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTANL 727
                       |: ||:..:.|............: .|.....:|..:||.||.:|.::||||||
  Rat   598 -----------PS-FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANL 650

  Fly   728 AAFLTVERMVAPIKTPEDLTMQ------TDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQH 786
            |||:..|..|..:....|...|      ....:||:..|||....|.:...:|..|.::   ||
  Rat   651 AAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKF---NQ- 711

  Fly   787 HSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPP-CD--TMKVGRNIDTKGFGVATPIGSPL 848
               ...|:.:..::..| ..|.:.::....|:..|.. |.  |:..|:...:.|:|:|....|..
  Rat   712 ---RGVDDALLSLKTGK-LDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGW 772

  Fly   849 RKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIV 913
            :::::.|:|.|..:||:..:...|.  ...|:.::.....::|.:.|:||::|:|...:.|::|.
  Rat   773 KRQVDLAILQLFGDGEMEELEALWL--TGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLIT 835

  Fly   914 AIME--FFCRNKTPQLKSPGSNGSAGGVPGMLAS 945
            .|.|  |:.:.:...:      |...|.|||:.|
  Rat   836 FICEHLFYWQFRHCFM------GVCSGKPGMVFS 863

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.