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Protein Alignment GluRIA and Grin2a

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_036705.3	Gene:	Grin2a / 24409	RGDID:	2737	Length:	1464	Species:	Rattus norvegicus

Alignment Length:	1005	Identity:	213/1005 - (21%)
Similarity:	370/1005 - (36%)	Gaps:	270/1005 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 AIFEQGTDDVQSAFKYAMLNHNLNVSSRRFE----------LQAYVDVI----NTADAFKLSRLI 94
            |..|:|...:..|   .:|.|:.:|:.|...          |...|:|:    |..|...|...:
  Rat    25 AAAEKGPPALNIA---VLLGHSHDVTERELRNLWGPEQATGLPLDVNVVALLMNRTDPKSLITHV 86

  Fly    95 CNQFS---------------RGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLA---PS 141
            |:..|               ..|..||..:|..:|..:........|          ::|   |:
  Rat    87 CDLMSGARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASM----------IMADKDPT 141

  Fly   142 SGLLDFAISMRPDYHQA--IIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVK 204
            |....|..|::   .||  ::..:|.|.|              .:..:...:.||...| :..:|
  Rat   142 STFFQFGASIQ---QQATVMLKIMQDYDW--------------HVFSLVTTIFPGYRDF-ISFIK 188

  Fly   205 -------------RIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRT 256
                         .:..:..:.|...|...|.:.....|:|.|..:.| .:|:...|.:.|....
  Rat   189 TTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEA-VLILSEARSLGLTGYD 252

  Fly   257 YHYLLSGLVMDN------HWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQN 315
            :.:::..||..|      .:||     |.|:::              :.|....||
  Rat   253 FFWIVPSLVSGNTELIPKEFPS-----GLISVS--------------YDDWDYSLE--------- 289

  Fly   316 AGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSA 380
                          |.:.|.:.:|..|            .|:.|::.|:...:.:|..|..|...
  Rat   290 --------------ARVRDGLGILTTA------------ASSMLEKFSYIPEAKASCYGQAEKPE 328

  Fly   381 LLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAE 445
                       ||.   ..:.:.:..|..||  .::.|.|:|.:::..|.|:.::.:...::|.:
  Rat   329 -----------TPL---HTLHQFMVNVTWDG--KDLSFTEEGYQVHPRLVVIVLNKDREWEKVGK 377

  Fly   446 WRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQY-TYGESLVGND--- 506
            |.:..     .|..:|...|..|.|..:.|.||..|| :|.|.|::.::.. ...|:.|.|.
  Rat   378 WENQT-----LSLRHAVWPRYKSFSDCEPDDNHLSIV-TLEEAPFVIVEDIDPLTETCVRNTVPC 436

  Fly   507 -RF-----------------EGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVG 553
             :|                 :|:|.|:...|:..:...|::.||.:|.:|.:   ....|:||:|
  Rat   437 RKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKK---VNNVWNGMIG 498

  Fly   554 ELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVI 618
            |::.:.|.:|:.::||..||..|:|||.||:..|||:|:.:. ..|....:||.|.|..:|:.:.
  Rat   499 EVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS-NGTVSPSAFLEPFSASVWVMMF 562

  Fly   619 LSYVGVSFVLYFVTR-FPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLN 682
            :..:.||.:..||.. |.|..:   .|..|...|...|                     .||:..
  Rat   563 VMLLIVSAIAVFVFEYFSPVGY---NRNLAKGKAPHGP---------------------SFTIGK 603

  Fly   683 SFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDL 746
            :.|............: .|.....:|..:||.||.:|.::|||||||||:..|..|..:....|.
  Rat   604 AIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDK 668

  Fly   747 TMQTDVNY------GTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHH------SVHT-------Y 792
            ..|...:|      ||:..|||....|.:...:|..|..:   ||..      |:.|       |
  Rat   669 KFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRF---NQRGVEDALVSLKTGKLDAFIY 730

  Fly   793 DEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVL 857
            |..:...:..:.:...||               |:..|....|.|:|:|...|||.:::::.|:|
  Rat   731 DAAVLNYKAGRDEGCKLV---------------TIGSGYIFATTGYGIALQKGSPWKRQIDLALL 780

  Fly   858 TLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF---- 918
            ....:||:..:...|.  ...|:.::.....::|.:.|:||::|:|...:.|::|..|.|.
  Rat   781 QFVGDGEMEELETLWL--TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYW 843

  Fly   919 ---FCRNKTPQLKSPGSNGSAGGVPGMLAS 945
               ||           ..|.....||:|.|
  Rat   844 KLRFC-----------FTGVCSDRPGLLFS 862

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.