Protein Alignment GluRIA and Grin1

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001257531.1
• Gene: Grin1 / 24408
• RGDID: 2736
• Length: 959
• Species: Rattus norvegicus
• Alignment Length: 1041
• Identity: 245/1041 - (23%)
• Similarity: 435/1041 - (41%)
• Gaps: 214/1041 - (20%)

  Fly     8 LAYLHFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRR 72
            ::.:|.:..:.:|...|:.|....:.|:      :||:.  .|...:..|:.|:...|....|.:
  Rat     1 MSTMHLLTFALLFSCSFARAACDPKIVN------IGAVL--STRKHEQMFREAVNQANKRHGSWK 57

  Fly    73 FELQAYVDVINTADAFKLSRLICNQ-FSRGVYSMLGAVSPDSFD----TLHSYSNTF-QMPFVTP 131
            .:|.| ..|.:..:|.:::..:|.. .|..||::|.:..|...|    |..||:..| ::|.:..
  Rat    58 IQLNA-TSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGL 121

  Fly   132 WFPEKVLAPSSGLLDFAISMRPDYHQAII--DTIQYYGWQSIIYLY-DSHDGLL---RLQQIYQE 190
            .....:.:..|..|.|..::.|..||:.:  :.::.|.|..||.|. |.|:|..   ||:.:.:|
  Rat   122 TTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEE 186

  Fly   191 LKPGNETFRVQMV-------KRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVR 248
            .:..::....:.:       ||.......::|     |.|..:...::::.....|:.||:....
  Rat   187 RESKSKKRNYENLDQLSYDNKRGPKAEKVLQF-----DPGTKNVTALLMEARELEARVIILSASE 246

  Fly   249 DIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQS 313
            |   ...|.:...:.|.|...        |.:.:.|.|.:..|          ..|..|.|....
  Rat   247 D---DAATVYRAAAMLNMTGS--------GYVWLVGEREISGN----------ALRYAPDGIIGL 290

  Fly   314 QNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNES 378
            |...|.|       ::|.:.|||.|:.:|.:.:|.|:                         |.:
  Rat   291 QLINGKN-------ESAHISDAVGVVAQAVHELLEKE-------------------------NIT 323

  Fly   379 SALLDC--NTSKGWVTPWEQGEKISRVLRKVE-IDGLSGEIRFDEDGRR--INYTLHVVEMSVNS 438
            .....|  ||:     .|:.|....|||...: .||::|.:.|:|||.|  .||::..::   |.
  Rat   324 DPPRGCVGNTN-----IWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQ---NR 380

  Fly   439 TLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLL------EEPYLSLK--- 494
            .|.||..: :...::|        :.|......|:.::...|.:|:.|      :||::.:|
  Rat   381 KLVQVGIY-NGTHVIP--------NDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTM 436

  Fly   495 -------QYTY-------------GESLVGNDRFE------GYCKDLADMLAAQLGIKYEIRLVQ 533
                   ::|.             .::..|:.|..      |:|.||...||..:...||:.||.
  Rat   437 SDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA 501

  Fly   534 DGNYGAE---NQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKP 595
            ||.:|.:   |......|:||:|||:..:||:.::.:||..||.:.|:|||||...|::|::||.
  Rat   502 DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKE 566

  Fly   596 VKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGG 660
            :.::. :.||:.|....:|:.|.||...|:.:||.:.||.|:     .|.:.:|..::...:
  Rat   567 IPRST-LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPF-----GRFKVNSEEEEEDAL--- 622

  Fly   661 ATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGC-DITPPSIAGRIAAAVWWFFTIILISSYT 724
                              |:.::.|:|....:..|. :..|.|.:.||...||..|.:|:::|||
  Rat   623 ------------------TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYT 669

  Fly   725 ANLAAFLTVER---MVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQH 786
            |||||||.::|   .:..|..|..........|.|:...|...:||| |:.| :.|:.:|   :.
  Rat   670 ANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRR-QVEL-STMYRHM---EK 729

  Fly   787 HSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKR 851
            |:..:..|.|:.||.:| .:|.:.:|...|: .|...||.:..|......|||:.....||.::.
  Rat   730 HNYESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQN 792

  Fly   852 LNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIM 916
            ::.::|...||| .:...:|.|....||  |..::.|..|:..|:||::.::.||::..:.:..:
  Rat   793 VSLSILKSHENG-FMEDLDKTWVRYQEC--DSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFI 854

  Fly   917 EFF------CRNKTPQL---------------KS------PGSNGSAGGVPGMLASSTYQRDSLS 954
            |..      .|.|..||               ||      |....:...:...||||..:|.|..
  Rat   855 EIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSK 919

  Fly   955 D 955
            |
  Rat   920 D 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	94/438 (21%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	119/443 (27%)
		Lig_chan	610..906	CDD:459656	79/299 (26%)
Grin1	NP_001257531.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	96/462 (21%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	120/440 (27%)
		CaM_bdg_C0	856..884	CDD:402271	4/27 (15%)