DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grik5

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	916	Identity:	300/916 - (32%)
Similarity:	470/916 - (51%)	Gaps:	144/916 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FEQGTDDVQSAFKYAMLNHNLNVSSR---------RFELQAYVDVINTA----DAFKLSR----- 92
            |...:..|.|:.:.|.:..:..|..|         |.::...::|...|    |.|:|.|
  Rat    13 FANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYE 77

  Fly    93 ---LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFA-ISMR 152
               .:|....:||.|:|| :.||.|..|:.......::|.:... ||:  .|....|.|| :|:.
  Rat    78 TTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG-PEE--TPRLQYLRFASVSLY 139

  Fly   153 P---DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIE 214
            |   |...|:...::.:.:.|...:....:.||||:::.:......||..|:|:....:.|
  Rat   140 PSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPT---- 200

  Fly   215 FLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLS----------GLVMDNH 269
              ..|:::.......|::|..|.:: .::::...::.:....|.|:|:          |:|.|:.
  Rat   201 --PLLKEIRDDKVSTIIIDANASIS-HLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSS 262

  Fly   270 WPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYD 334
                       ||.||.:.:::.....:|..|   |..|.:...:.:..|.  ||:|  ||||:|
  Rat   263 -----------NILGFSMFNTSHPFYPEFVRS---LNMSWRENCEASTYPG--PALS--AALMFD 309

  Fly   335 AVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEK 399
            ||.|:|.|.             ..|.|....|....:.|..|                .|..|..
  Rat   310 AVHVVVSAV-------------RELNRSQEIGVKPLACTSAN----------------IWPHGTS 345

  Fly   400 ISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSS 464
            :...||.||.|||:|.:.|:..|:|.||||.::|.| ....:::..|             |::.:
  Rat   346 LMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKS-RQGHREIGVW-------------YSNRT 396

  Fly   465 RSASASTGDYD-----RNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLG 524
            .:.:|:|.|.:     .|.|.:|:::||.||: :::..: ::|.||:||||:|.|:...||..|.
  Rat   397 LAMNATTLDINLSQTLANKTLVVTTILENPYV-MRRPNF-QALSGNERFEGFCVDMLRELAELLR 459

  Fly   525 IKYEIRLVQDGNYGAENQYAPGGWDGMVGELI-RKEADIAISAMTITAERERVIDFSKPFMTLGI 588
            .:|.:|||:||.|||..  ..|.|.||||||| |::||:|::|.|||||||:|||||||||||||
  Rat   460 FRYRLRLVEDGLYGAPE--PNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGI 522

  Fly   589 SIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQ 653
            ||:.:..:.:.||.||||:|.|..:|:.::|:|:.||.||:...|..||||   ..|.....|:
  Rat   523 SILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW---YNPHPCLRAR- 583

  Fly   654 PPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTII 718
                             |.:..|::|:.||.|:.:..|||||.:|.|.:::.|..:.|||.||:|
  Rat   584 -----------------PHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLI 631

  Fly   719 LISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNA 783
            :||||||||||||||:||..|:::.:||..||::.|||:..|||..||:.|:...:.:||.||.:
  Rat   632 IISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQS 696

  Fly   784 NQHH-SVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSP 847
            .|.. .|.:.:|||.||..|  :||.|:||..||| :.|..|:..::|..:||||:|:..|:|||
  Rat   697 KQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKGYGIGMPLGSP 758

  Fly   848 LRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVI 912
            .|..:..|:|.|:||..|..::.||| :...|. .:|......|.:.|:.||:.:||.||::||.
  Rat   759 FRDEITLAILQLQENNRLEILKRKWW-EGGRCP-KEEDHRAKGLGMENIGGIFVVLICGLIIAVF 821

  Fly   913 VAIMEF 918
            ||:|||
  Rat   822 VAVMEF 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	101/442 (23%)
		ANF_receptor	53..434	CDD:279440	97/416 (23%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	178/403 (44%)
		Lig_chan	612..907	CDD:278489	114/295 (39%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	99/448 (22%)
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	178/399 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349657
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650