Protein Alignment GluRIA and Grik4

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_036704.1
• Gene: Grik4 / 24406
• RGDID: 2734
• Length: 956
• Species: Rattus norvegicus
• Alignment Length: 911
• Identity: 291/911 - (31%)
• Similarity: 456/911 - (50%)
• Gaps: 147/911 - (16%)

  Fly    76 QAYVDVINTADAFKLSR--------LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMP---- 127
            :|.|:|    |.|:|.|        .:|....:||.::|| :.||.|...:.:.....::|
  Rat    61 KAKVEV----DIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKV 121

  Fly   128 -------FVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQ 185
                   |....|....|.||:          .|...|:...:.::...:...:....:.||.|:
  Rat   122 APEEFVRFQLQRFTTLNLHPSN----------TDISVAVAGILNFFNCTTACLICAKAECLLNLE 176

  Fly   186 QIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDI 250
            ::.::.....:|..|:|:....:.|      ..|:::.......|::...|.|:..|::: ..::
  Rat   177 KLLRQFLISKDTLSVRMLDDTRDPT------PLLKEIRDDKTATIIIHANASMSHTILLK-AAEL 234

  Fly   251 KLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQN 315
            .:....|.|:.:.|.........:|: ..:||.||.|.:.:....::|..|   |..|.|....:
  Rat   235 GMVSAYYTYIFTNLEFSLQRMDSLVD-DRVNILGFSIFNQSHAFFQEFSQS---LNQSWQENCDH 295

  Fly   316 AGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSA 380
            .  |.:.||:|  :||::|||:.:|.|...:.|                     |...|...
  Rat   296 V--PFTGPALS--SALLFDAVYAVVTAVQELNR---------------------SQEIGVKP--- 332

  Fly   381 LLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAE 445
             |.|.:::    .|:.|..:...||.||::||:|.|.|:..|:|.||.|.:::.:.|. .:|:.:
  Rat   333 -LSCGSAQ----IWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNG-FRQIGQ 391

  Fly   446 WRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYG--ESLVGNDRF 508
            |....||        :..||..:::..|...|.|.:|:::||.|||.||    |  :.:.||||:
  Rat   392 WHVAEGL--------SMDSRLYASNISDSLFNTTLVVTTILENPYLMLK----GNHQDMEGNDRY 444

  Fly   509 EGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAER 573
            ||:|.|:...||..|...|:||||.||.||...  |.|.|.|||||||.::||:|::.:||||||
  Rat   445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE--ANGTWTGMVGELIARKADLAVAGLTITAER 507

  Fly   574 ERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYE 638
            |:|||||||||||||||:.:..:.:.||.||||:|.|..:|:.::|:|:.||.||:.|.|..|||
  Rat   508 EKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYE 572

  Fly   639 WRIVRRPQADSTAQQP-PGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPS 702
            |            ..| |...|...|.          .|::::.||.|:.:..|||||..|.|.:
  Rat   573 W------------YSPHPCAQGRCNLL----------VNQYSLGNSLWFPVGGFMQQGSTIAPRA 615

  Fly   703 IAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFR 767
            ::.|..:.|||.||:|:||||||||||||||:||..||::.:||..||.:.|||:..||:..||:
  Rat   616 LSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQ 680

  Fly   768 RSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGR 831
            .|:...:.:||.||.:.|.. .|.:.:|||.||..|  .||.|:||..|||...| .|:..::|.
  Rat   681 NSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS--NYAFLLESTMNEYYRQR-NCNLTQIGG 742

  Fly   832 NIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNV 896
            .:||||:|:..|:||..|...:.|:|.|:||..|..::.||| :..:|. .:|......|.:.|:
  Rat   743 LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWW-EGGKCP-KEEDHRAKGLGMENI 805

  Fly   897 AGIYYILIGGLLLAVIVAIMEFF-------------CRNKTPQLKS---------PGSNGSAGGV 939
            .||:.:||.||::|:.:|::||.             |:....:|:|         |....| ||:
  Rat   806 GGIFVVLICGLIVAIFMAMLEFLWTLRHSEASEVSVCQEMMTELRSIILCQDNIHPRRRRS-GGL 869

  Fly   940 P 940
            |
  Rat   870 P 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	86/399 (22%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	180/405 (44%)
		Lig_chan	610..906	CDD:459656	115/297 (39%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	86/407 (21%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	180/401 (45%)
		QRL_CxxC_CxxC	863..927	CDD:469521	4/9 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956