DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GluRIA and Grin3a

DIOPT Version :9

Sequence 1:NP_476855.1 Gene:GluRIA / 38742 FlyBaseID:FBgn0004619 Length:991 Species:Drosophila melanogaster
Sequence 2:NP_001263284.1 Gene:Grin3a / 242443 MGIID:1933206 Length:1135 Species:Mus musculus


Alignment Length:929 Identity:195/929 - (20%)
Similarity:355/929 - (38%) Gaps:246/929 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 EKVLAPSSGLLDFAI----------SMRP-DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIY 188
            |.|:|..:||.|..:          |..| .:.|::..|:...|..:::....|.          
Mouse   149 EVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQ---------- 203

  Fly   189 QELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLG 253
                  .|...:.:|..:.::.:.....|   :..|.|:..:.|    :::.|..:....|:.:.
Mouse   204 ------GEMMELDLVSSVLHIPVLSIVRH---EFPRESQNPLHL----QLSLENSLSSDADVTVS 255

  Fly   254 RRTYH--YLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFH-----------DSRKRL 305
            ..|.:  |..|.|:....|          |||.|.::..|.   ..||           .|.|.|
Mouse   256 ILTMNNWYNFSLLLCQEDW----------NITDFLLLTENN---SKFHLESIINITANLSSTKDL 307

  Fly   306 EPSGQSQSQNAGGPNSLPA----------------ISAQAALM-YDAVFVLVEAFNRILRKKPDQ 353
            ....|.|.:|.  .||.|.                :|.|..|. .|..:||.::.|      .::
Mouse   308 LSFLQVQLENI--RNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLHWVLGDSQN------VEE 364

  Fly   354 FRSNHLQRR--SHGGSSSS------------------SATGTNESSALL----DCNTSKGWVTPW 394
            .|:..|...  :||.::.|                  :||......|||    :|...|  .|..
Mouse   365 LRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVK--TTNL 427

  Fly   395 EQGEKISRVLRKVEIDGLSGEIR-------------------FDEDGRRINYTLHVVEMSVNSTL 440
            ..|:.:||.|......||||.|:                   :|..|:.: :|            
Mouse   428 TSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPM-WT------------ 479

  Fly   441 QQVAEWRD-----DAGLLPLHSHNYASSSRSASASTGDYDRNHTYI-VSSLLEEPY--------- 490
             ::..|:.     |:|:.|..:..:         .|..:..|..:: |.:|:|.|:         
Mouse   480 -RLGSWQGGRIVMDSGIWP
EQAQRH---------KTHFHHPNKLHLRVVTLIEHPFVFTREVDDE 534

  Fly   491 -------LSLKQYTYGESLV---------GND----RFE----GYCKDLADMLAAQLGIKYEIRL 531
                   |.|...|...|::         .||    :|:    |||.||.:.||..:...:::.:
Mouse   535 GLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYI 599

  Fly   532 VQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPV 596
            |.||.|||   :..|.|.|:||:|:...|::|:::.:|...|.:||||:.||.:..:.|:::...
Mouse   600 VGDGKYGA---WKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRD 661

  Fly   597 KQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGA 661
            ...| :.:|:.||...:|:.:   :|.:.....|:|.   |||:            .|.|     
Mouse   662 TAAP-IGAFMWPLHWTMWLGI---FVALHITAIFLTL---YEWK------------SPFG----- 702

  Fly   662 TLSEPQAHVPPVPPNE---FTMLNSFWYSLAAFMQQGCDITPPSI-AGRIAAAVWWFFTIILISS 722
                    :.|...|.   |:..::.....|....:...|.||.. .||....:|..|.:..:|:
Mouse   703 --------MTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLST 759

  Fly   723 YTANLAAFLTVERM---VAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNAN 784
            |||||||.:..|::   ::.|..|:.........:||:...|..::.|:|...:|    |||   
Mouse   760 YTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMH----EYM--- 817

  Fly   785 QHHSVHTYDEGIRRVRQSKGKY-ALLVESPKNEY-VNARPPCDTMKVGRNIDTKGFGVATPIGSP 847
            :.::|....:|::.::....|. |.:::....:| |:....|..:.||:....:|:|:..|..||
Mouse   818 RRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSP 882

  Fly   848 LRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPN-ELSLSNVAGIYYILIGGLLLAV 911
            |...::|.:...|.:|.:..:.:| |:....|.......|.. ::.:.:.:|::.:|..|..|::
Mouse   883 LTSNISELISQYKSHGFMDVLHDK-WYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSI 946

  Fly   912 IVAIMEFFC-RNKTPQLKS 929
            :..|.|... |...|::|:
Mouse   947 LTTIGEHIVYRLLLPRIKN 965

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIANP_476855.1 PBP1_iGluR_AMPA 41..453 CDD:107375 76/406 (19%)
ANF_receptor 53..434 CDD:279440 73/382 (19%)
PBP2_iGluR_AMPA 477..879 CDD:270433 106/444 (24%)
Lig_chan 612..907 CDD:278489 64/304 (21%)
Grin3aNP_001263284.1 PBP1_iGluR_NMDA_NR3 30..497 CDD:107372 76/407 (19%)
PBP2_iGluR_NMDA_Nr3 512..908 CDD:270438 104/438 (24%)
Lig_chan 676..942 CDD:278489 64/304 (21%)
PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7 951..987 4/15 (27%)
GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7 1082..1115
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846178
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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