DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grin3a

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	922	Identity:	192/922 - (20%)
Similarity:	354/922 - (38%)	Gaps:	232/922 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 EKVLAPSSGLLDFAI----------SMRP-DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIY 188
            |.|:|..:||.|..:          |..| .:.|::..|:...|..:::....|.
  Rat   149 EVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQ---------- 203

  Fly   189 QELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLG 253
                  .|...:.:|..:.::.:.....|   :..|.|:..:.|    :::.|..:....|:.:.
  Rat   204 ------GEMMELDLVSSVLHIPVLSIVRH---EFPRESQNPLHL----QLSLENSLSSDADVTVS 255

  Fly   254 RRTYH--YLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFH-----------DSRKRL 305
            ..|.:  |..|.|:....|          |||.|.::..|.   ..||           .|.|.|
  Rat   256 ILTMNNWYNFSLLLCQEDW----------NITDFLLLTENN---SKFHLESVINITANLSSTKDL 307

  Fly   306 EPSGQSQSQNAGGPNSLPAISAQAALMY----DAVFVLVEAFNRILRKKP------------DQF 354
            ....|.|..|.  .||.|.:     :|:    |::..:.|...:.....|            ::.
  Rat   308 LSFLQVQMDNI--RNSTPTM-----VMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGDSQNVEEL 365

  Fly   355 RSNHLQRR--SHGGSSSS------------------SATGTNESSALL----DCNTSKGWVTPWE 395
            |:..|...  :||.::.|                  :||......|||    :|...|  .|...
  Rat   366 RTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVK--TTNLT 428

  Fly   396 QGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNS----TLQ----------QVAEW 446
            .|:.:||.|......||||.|:....         .:..|.|:    .||          ::..|
  Rat   429 SGQYLSRFLANTTFRGLSGSIKVKGS---------TIISSENNFFIWNLQHDPMGKPMWTRLGSW 484

  Fly   447 RD-----DAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPY---------------- 490
            :.     |:|:.|..:..:.:..:..       ::.|..:| :|:|.|:
  Rat   485 QGGRIVMDSGIWPEQAQRHKTHFQHP-------NKLHLRVV-TLIEHPFVFTREVDDEGLCPAGQ 541

  Fly   491 LSLKQYTYGESLV---------GND----RFE----GYCKDLADMLAAQLGIKYEIRLVQDGNYG 538
            |.|...|...|::         .||    :|:    |||.||.:.||..:...:::.:|.||.||
  Rat   542 LCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYG 606

  Fly   539 AENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVF 603
            |   :..|.|.|:||:|:...|::|:::.:|...|.:||||:.||.:..:.|:::......| :.
  Rat   607 A---WKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP-IG 667

  Fly   604 SFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQA 668
            :|:.||...:|:.:   :|.:.....|:|.   |||:            .|.|
  Rat   668 AFMWPLHWTMWLGI---FVALHITAIFLTL---YEWK------------SPFG------------ 702

  Fly   669 HVPPVPPNE---FTMLNSFWYSLAAFMQQGCDITPPSI-AGRIAAAVWWFFTIILISSYTANLAA 729
             :.|...|.   |:..::.....|....:...|.||.. .||....:|..|.:..:|:|||||||
  Rat   703 -MTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAA 766

  Fly   730 FLTVERM---VAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHT 791
            .:..|::   ::.|..|:.........:||:...|..::.|:|...:|    |||   :.::|..
  Rat   767 VMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMH----EYM---RRYNVPA 824

  Fly   792 YDEGIRRVRQSKGKY-ALLVESPKNEY-VNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNE 854
            ..:|::.::....|. |.:::....:| |:....|..:.||:....:|:|:..|..|||...::|
  Rat   825 TPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISE 889

  Fly   855 AVLTLKENGELLRIRNKWWFDKTECNLDQETSTPN-ELSLSNVAGIYYILIGGLLLAVIVAIMEF 918
            .:...|.:|.:..:.:| |:....|.......|.. ::.:.:.:|::.:|..|..|:::..|.|.
  Rat   890 LISQYKSHGFMDVLHDK-WYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEH 953

  Fly   919 FC-RNKTPQLKS 929
            .. |...|::|:
  Rat   954 IVHRLLLPRIKN 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	74/400 (19%)
		ANF_receptor	53..434	CDD:279440	67/362 (19%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	106/443 (24%)
		Lig_chan	612..907	CDD:278489	64/304 (21%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	74/401 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440	69/373 (18%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	105/439 (24%)
		Lig_chan	676..942	CDD:278489	64/304 (21%)
		PPP2CB binding site	951..987		4/15 (27%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349640
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740