DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIA and ZK867.2

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001355384.1	Gene:	ZK867.2 / 191445	WormBaseID:	WBGene00022829	Length:	354	Species:	Caenorhabditis elegans

Alignment Length:	136	Identity:	33/136 - (24%)
Similarity:	59/136 - (43%)	Gaps:	27/136 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 VGNDRFEGYCKDLADMLAAQLGIKYEI-----RLVQDGNYGAENQYAPGGWDGMVGELIRKEADI 562
            |.|.:..|...::..|:...:|:.|.:     :..|..::|::.:  .|.|.||:|.|...:.|:
Worm    21 VPNCKHPGAEVEILKMIFRLIGVNYTMIDVWKKFGQQYDFGSKQK--NGNWSGMIGLLQSDQLDM 83

  Fly   563 AISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFV 627
            ...:|.|..|||.|:.||.|......||.            ||  |:|..:.:.:||      ..
Worm    84 IGLSMRIAPEREEVVLFSYPTRVFETSIQ------------SF--PVSSRMLLLIIL------IA 128

  Fly   628 LYFVTR 633
            .:|:::
Worm   129 TFFISQ 134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375
		ANF_receptor	53..434	CDD:279440
		PBP2_iGluR_AMPA	477..879	CDD:270433	33/136 (24%)
		Lig_chan	612..907	CDD:278489	3/22 (14%)
ZK867.2	NP_001355384.1	Lig_chan-Glu_bd	22..77	CDD:214911	12/56 (21%)
ZK867.2	NP_001355384.1	Periplasmic_Binding_Protein_Type_2	<69..>103	CDD:389745	14/33 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900