DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and glr-7

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001337310.1	Gene:	glr-7 / 180547	WormBaseID:	WBGene00001618	Length:	885	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	139/544 - (25%)
Similarity:	256/544 - (47%)	Gaps:	93/544 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   426 NYT---LHVVEMSVNSTLQQVAEWRDDAGLL---------PLHSHNYASSSRSASASTGDYD-RN 477
            |||   |::....|...:.::...||....|         |:       |..|....|...| ||
Worm   313 NYTEAGLNMFFQDVEVRIYKIDRDRDHEDALFNKEVGVWSPI-------SKLSVMYGTLQVDVRN 370

  Fly   478 -HTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAEN 541
             :.:.|.:|::.|::   |.| |:.   :..:||||.||.:|:..::...|.|..|:||::|..:
Worm   371 LNIFRVVTLIQPPFV---QRT-GDP---DTPYEGYCIDLINMIQVEVNFTYTIYEVEDGSFGTMD 428

  Fly   542 QYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTL-GISIMIKKPVKQTPGVFSF 605
            .  .|.|:|::|.|:...||||::.:::.||||..:||:.|:..| |.:|::||...:. .:|.|
Worm   429 D--NGNWNGLIGALVSGSADIALAPLSVMAERENDVDFTVPYYDLVGTTILMKKADVEY-SLFKF 490

  Fly   606 LNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHV 670
            :..|...:|:.::.:|:..|.:|:...||.||.:                       .:..:.:.
Worm   491 MKVLEWPVWLCIVAAYLFTSILLWIFDRFSPYSF-----------------------TNNKERYQ 532

  Fly   671 PPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVER 735
            ..:...:|::....|:.:.:...||....|.:|:||:.||.||.|..|:|:||||||||||||.|
Worm   533 NDIEKRQFSLKECLWFCMTSLTPQGGGEAPKNISGRLVAATWWLFGFIIIASYTANLAAFLTVSR 597

  Fly   736 MVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRR------------SQIGLHNKM----------W 778
            :..||.:.:||..|..:.|..:...::..:|||            .::.|:..|          |
Worm   598 LEQPISSLDDLAKQYKIEYAPIKGSASETYFRRMAEIEETFYNMWKEMSLNESMSPRDRAKLAVW 662

  Fly   779 EYMNANQHHSVHTY----------DEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNI 833
            :|..:::..::..|          |..:.||..|...:|.:.::.:.:|. |...|:..:||...
Worm   663 DYPVSDKFTNMWRYMQESKLPVNMDTAVDRVLNSVDGFAFIGDATEIKYA-ALTNCNLQQVGTEF 726

  Fly   834 DTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFD---KTECNLDQETSTPNELSLSN 895
            ..|.:.:|...|..|:.:::.|:|.|.....|..::.|||.|   |..|....:.|  :.:|:.|
Worm   727 SRKPYAIAVQSGHILKDKISSAILMLLNERRLETLKEKWWTDNPNKVSCPDSSDES--DGISIQN 789

  Fly   896 VAGIYYILIGGLLLAVIVAIMEFF 919
            :.|::.:::.|:.|:::....|::
Worm   790 IGGVFIVILAGIALSIVTLAFEYY 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	7/29 (24%)
		ANF_receptor	53..434	CDD:279440	4/10 (40%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	117/438 (27%)
		Lig_chan	612..907	CDD:278489	78/329 (24%)
glr-7	NP_001337310.1	Periplasmic_Binding_Protein_Type_1	<102..>220	CDD:324556
glr-7	NP_001337310.1	PBP2_iGluR_putative	373..767	CDD:270435	113/427 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810