DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and glr-5

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_505244.1	Gene:	glr-5 / 179251	WormBaseID:	WBGene00001616	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	935	Identity:	257/935 - (27%)
Similarity:	440/935 - (47%)	Gaps:	147/935 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LGAIFEQGTD-DVQSAFKYAM-------LNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQF 98
            :||||.:..| .:::|.:|::       :..::::      :..|:||::..||.|.:   |...
Worm    27 IGAIFREREDAHIEAAVRYSVEWLSQRGIYGDIDL------VIEYIDVLDHYDAIKKA---CKML 82

  Fly    99 SRG-VYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISM---------RP 153
            .:. :.::||.........|...::...:||:|            .:.|....|         ||
Worm    83 EKDHIVALLGGSHAALNAQLERITDDLDIPFLT------------AIDDLRTDMGKSKIDFWPRP 135

  Fly   154 DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQ------------ELKPGNETFRVQMVKRI 206
            ...:|::|...::.|..|:.:|:..:.:.||:|:.:            ::..|:.....:.||.:
Worm   136 QLFEAVVDMFTHWRWNRIVLVYEGDERIRRLEQLLESEEYASIRFYLIKVHDGDYMKAARQVKEL 200

  Fly   207 ANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLS----GLVMD 267
            ....:    ||. :|...||  |:::|...|                 .||.:||:    ||:..
Worm   201 EECRL----LHK-KDCSEFS--RLLVDMNPE-----------------HTYTFLLASLQMGLIEL 241

  Fly   268 NHW-PSDVVEFGAINITGFRI----------VDS-----NRRAVRDFHDSRKRLEPSGQSQSQNA 316
            .|| ....:|...:::..||.          |||     ||.|. :|...::.:......::.|:
Worm   242 KHWFLLTNMELSTMDMELFRYNHARFISPYPVDSTFLTENRDAF-NFSHFKEHITEKWAMKTDNS 305

  Fly   317 GGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSAL 381
            .....:     :|...:|||:.....||.:         |:|:|              .|:....
Worm   306 RNLKMM-----EAVFTFDAVYAFANVFNEL---------SSHMQ--------------MNDVPQT 342

  Fly   382 LDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEI-RFDEDGRRINYTLHVVEMSVNSTLQQVAE 445
            | |..|......::.|..:...:...::.||||:: |.:....:.|:::.:..:..:..|..:..
Worm   343 L-CRKSSRNSRKYQHGRSLIDNIVHNDLHGLSGDLRRLNGHPLKSNFSMRIQLLGYSGRLDDIGF 406

  Fly   446 WRDDAGL-LPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFE 509
            |.....: :.:...:.|...|:...|  |..:.| :.|::::|.||:.||:..|  .|..|.:||
Worm   407 WEPATNVHVNMSGDSKAQLQRNVQVS--DELKPH-FRVTTIMERPYVMLKKNHY--ELDANSKFE 466

  Fly   510 GYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERE 574
            |:|.||...|:..||..|.|..|:||.|| .::|..|.||||:||::|.||::|::.:|:...|.
Worm   467 GFCIDLLAELSKDLGFTYTIHAVKDGKYG-NDKYGNGSWDGMMGEILRGEAEMAVAPLTVNYRRS 530

  Fly   575 RVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEW 639
            ..:||:|||::|||||:.|.|..|.|.:||||||||.:||.::..|.:.|:..:|||....||||
Worm   531 EAVDFTKPFLSLGISILYKVPDDQQPDLFSFLNPLSWQIWTAIATSIITVTLGMYFVANVTPYEW 595

  Fly   640 RIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIA 704
            .:   ..:..||.:|......||..|    .|.|..|.::..|:.||.|:..::.|||..|.:::
Worm   596 NL---NFSCCTAHEPHPAAAFATNQE----APIVMSNNYSFWNTVWYVLSTMLKGGCDFGPRAVS 653

  Fly   705 GRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRS 769
            .|:....||.|.:::||:|||||||.|||.|...|||..:||..||.::|||:..|||.:||:.|
Worm   654 TRLLGGTWWVFYLVIISAYTANLAAVLTVSRPYIPIKNLDDLANQTTISYGTIRGGSTMQFFQES 718

  Fly   770 QIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNID 834
            :|..|.|||:||. ::...|.:..:|:.|....  .||.|:||...|| ..:..|:..::|..:.
Worm   719 RIAAHVKMWQYMK-DKDVFVTSNGKGVERALSM--NYAYLMESTSLEY-ETQQNCNLTQIGGVLG 779

  Fly   835 TKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNE---LSLSNV 896
            :||:|:|....|....|::..:|...:.|.:...:.|||..|........::..::   ||:.||
Worm   780 SKGYGIALAKKSEWTDRISRQILLYAKRGIIEMKKTKWWRSKGAACASTASAVKHDRFALSMYNV 844

  Fly   897 AGIYYILIGGLLLAVIVAIMEFFCR 921
            ||::..|..|::||.||.|.|...|
Worm   845 AGLFITLGVGIVLAAIVVIFELIHR 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	84/462 (18%)
		ANF_receptor	53..434	CDD:279440	77/430 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	154/401 (38%)
		Lig_chan	612..907	CDD:278489	99/297 (33%)
glr-5	NP_505244.1	PBP1_iGluR_delta_like	26..418	CDD:107376	84/465 (18%)
		ANF_receptor	38..377	CDD:279440	75/413 (18%)
		PBP2_iGluR_Kainate	438..819	CDD:270432	152/395 (38%)
		Lig_chan	568..855	CDD:278489	99/297 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840