Protein Alignment GluRIA and glr-2

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001021114.1
• Gene: glr-2 / 175999
• WormBaseID: WBGene00001613
• Length: 977
• Species: Caenorhabditis elegans
• Alignment Length: 1002
• Identity: 343/1002 - (34%)
• Similarity: 520/1002 - (51%)
• Gaps: 164/1002 - (16%)

  Fly    37 TEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVD---VINTAD---------AFK 89
            ::|.||.|..  .:.|:.:...:|:: ..|.::...|...:.||   ::.|.|         .:.
 Worm    20 SKKFPLRAFV--ASTDIDNDTAHAII-EMLRLAEMTFNALSDVDFDVLLGTRDLPPMEMATMMWN 81

  Fly    90 LSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKV--LAPSSGLLDFAISMR 152
            |:|:||::...|...||...:..::......:|..:||.: .|.|.|.  :..::.......|:.
 Worm    82 LNRIICDEMKLGYMLMLAGTNFKNYGIYEDIANHMKMPLI-DWEPSKSENIGKTTENNPMIFSVA 145

  Fly   153 PDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIA--NVTMAIEF 215
            |...|.:||.|||.||:.::|::|..:....|:.::..|...:..:::.:...:|  :..|..||
 Worm   146 PSAEQLLIDYIQYKGWRDVVYIHDGKNADRTLRTMFSYLHEKSPKYQLFVDNYVAPSDEEMFKEF 210

  Fly   216 L----------HTL------EDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGL 264
            |          |||      |::.......:::|..........::.:.:..|.::.|||:.|..
 Worm   211 LNEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVDLEGSYRTRAFLRALEESVLVKKEYHYVFSNF 275

  Fly   265 VMDNHWPSDV--VEFGAINITGFRIVDSNRRAV----RDFHDSRKRLEPSGQSQSQNAGGPNSLP 323
            .:|.   :|:  ..|..||||.|||.|.|.:..    .:|||..:             ||.::..
 Worm   276 DVDE---TDLSGFHFSLINITIFRIFDKNNKKFLKTRAEFHDVYR-------------GGFSNTD 324

  Fly   324 AISAQAALMYDAVFVLVEAFNRILRKK-----PDQFRSNHLQRRSHGGSSSSSATGTNESSALLD 383
            :|...||..:||:.|..:|....:.:.     ...|..:.|..|...|               |.
 Worm   325 SIPTAAAFAHDAILVAGKALQIAMNEHGKGIFDKSFVRHQLFNRGRKG---------------LY 374

  Fly   384 C-----NTSKGWVTPWEQGEKISRVLRKVEI---DG-LSGEIRFDE-DGRRINYTLHVVEM---- 434
            |     .|.......:|.|:||:..::||.:   || |:|.|:||: .|:|.|::..:||:
 Worm   375 CRPHEDQTESRQFETFEHGKKIAEAIKKVVLTDKDGTLTGRIQFDKVTGKRTNFSAEIVEIKPGV 439

  Fly   435 -SVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNH---------TYIVSSLLEEP 489
             |:||..::. :|.:..|.| |....|....:..|:.|    |..         .:.|.::|.:|
 Worm   440 NSLNSIWERF-QWAEGEGFL-LGGERYVQEKKKDSSQT----RKGILPSKPWQLRFNVVTVLVKP 498

  Fly   490 YLSLKQYTYGE-SLVGNDRFEGYCKDLADMLAAQL-GIKYEIRLVQDGN-YGAENQYAPGGWDGM 551
            ::.||:...|| .|.|||||||||.||.::||..: |.:|:: .:.||| ||  ::.|.|.||||
 Worm   499 FVMLKRRNPGEPELKGNDRFEGYCIDLLNLLAKNITGFEYDV-FISDGNKYG--SRQADGSWDGM 560

  Fly   552 VGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWIS 616
            :|.|:.:.||:|::.:|||.||||.:||||||||.|||||||||.||...:|||:.||...|||.
 Worm   561 IGYLLNETADVAVAPLTITQERERAVDFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIF 625

  Fly   617 VILSYVGVSFVLYFVTRFPPYEWRI-VRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTM 680
            .:.||.|||..::.|:.|.|||.|| .:|.:...|                         ||||:
 Worm   626 TLSSYFGVSLTIFLVSWFSPYEKRIEFKRGEFTVT-------------------------NEFTL 665

  Fly   681 LNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPED 745
            .||.|::||||||||.||.|.:::||||::.|||||:|::||||||||||||:|||..||::.||
 Worm   666 YNSLWFTLAAFMQQGTDILPRAVSGRIASSCWWFFTLIIVSSYTANLAAFLTLERMTPPIESVED 730

  Fly   746 LTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-----------------NANQHHSVHTYD 793
            |..|..:.||....|||..||..|.:.|:.|||.:|                 :.:....|.:|.
 Worm   731 LANQNKILYGVNEGGSTAAFFEDSIVPLYKKMWNFMVSTTQKQIELEKQSITNSTSNRIFVSSYA 795

  Fly   794 EGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLT 858
            :||.:||.||||||.|:|...|.|.:.|.||||||||:|::|.|:|:||.||:|||..||.|:|.
 Worm   796 DGIEKVRTSKGKYAFLLEETTNNYESGRRPCDTMKVGQNLNTLGYGIATKIGNPLRVSLNLAILY 860

  Fly   859 LKENGELLRIRNKWWFDKTECNLDQETS---TPNELSLSNVAGIYYILIGGLLLAVIVAIMEF-F 919
            |.|.|||.::.||||:|:.:|  |..||   |.:.|:||.||||:|||:.|::|::..|::|| |
 Worm   861 LSEKGELKKLENKWWYDRGQC--DTGTSDGGTSSSLNLSKVAGIFYILLAGMVLSMCTALVEFLF 923

  Fly   920 CRNKTPQLKSPGSNGSAGGV-PGMLAS 945
            .:||..:.|......|:..: ||:|||
 Worm   924 RKNKENREKERNRMRSSRPLKPGILAS 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	108/472 (23%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	199/431 (46%)
		Lig_chan	610..906	CDD:459656	144/316 (46%)
glr-2	NP_001021114.1	PBP1_iGluR_AMPA	24..460	CDD:380603	108/472 (23%)
		Periplasmic_Binding_Protein_Type_2	491..875	CDD:473866	196/411 (48%)