DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and glr-2

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001021114.1	Gene:	glr-2 / 175999	WormBaseID:	WBGene00001613	Length:	977	Species:	Caenorhabditis elegans

Alignment Length:	1002	Identity:	343/1002 - (34%)
Similarity:	520/1002 - (51%)	Gaps:	164/1002 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVD---VINTAD---------AFK 89
            ::|.||.|..  .:.|:.:...:|:: ..|.::...|...:.||   ::.|.|         .:.
Worm    20 SKKFPLRAFV--ASTDIDNDTAHAII-EMLRLAEMTFNALSDVDFDVLLGTRDLPPMEMATMMWN 81

  Fly    90 LSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKV--LAPSSGLLDFAISMR 152
            |:|:||::...|...||...:..::......:|..:||.: .|.|.|.  :..::.......|:.
Worm    82 LNRIICDEMKLGYMLMLAGTNFKNYGIYEDIANHMKMPLI-DWEPSKSENIGKTTENNPMIFSVA 145

  Fly   153 PDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIA--NVTMAIEF 215
            |...|.:||.|||.||:.::|::|..:....|:.::..|...:..:::.:...:|  :..|..||
Worm   146 PSAEQLLIDYIQYKGWRDVVYIHDGKNADRTLRTMFSYLHEKSPKYQLFVDNYVAPSDEEMFKEF 210

  Fly   216 L----------HTL------EDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGL 264
            |          |||      |::.......:::|..........::.:.:..|.::.|||:.|..
Worm   211 LNEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVDLEGSYRTRAFLRALEESVLVKKEYHYVFSNF 275

  Fly   265 VMDNHWPSDV--VEFGAINITGFRIVDSNRRAV----RDFHDSRKRLEPSGQSQSQNAGGPNSLP 323
            .:|.   :|:  ..|..||||.|||.|.|.:..    .:|||..:             ||.::..
Worm   276 DVDE---TDLSGFHFSLINITIFRIFDKNNKKFLKTRAEFHDVYR-------------GGFSNTD 324

  Fly   324 AISAQAALMYDAVFVLVEAFNRILRKK-----PDQFRSNHLQRRSHGGSSSSSATGTNESSALLD 383
            :|...||..:||:.|..:|....:.:.     ...|..:.|..|...|               |.
Worm   325 SIPTAAAFAHDAILVAGKALQIAMNEHGKGIFDKSFVRHQLFNRGRKG---------------LY 374

  Fly   384 C-----NTSKGWVTPWEQGEKISRVLRKVEI---DG-LSGEIRFDE-DGRRINYTLHVVEM---- 434
            |     .|.......:|.|:||:..::||.:   || |:|.|:||: .|:|.|::..:||:
Worm   375 CRPHEDQTESRQFETFEHGKKIAEAIKKVVLTDKDGTLTGRIQFDKVTGKRTNFSAEIVEIKPGV 439

  Fly   435 -SVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNH---------TYIVSSLLEEP 489
             |:||..::. :|.:..|.| |....|....:..|:.|    |..         .:.|.::|.:|
Worm   440 NSLNSIWERF-QWAEGEGFL-LGGERYVQEKKKDSSQT----RKGILPSKPWQLRFNVVTVLVKP 498

  Fly   490 YLSLKQYTYGE-SLVGNDRFEGYCKDLADMLAAQL-GIKYEIRLVQDGN-YGAENQYAPGGWDGM 551
            ::.||:...|| .|.|||||||||.||.::||..: |.:|:: .:.||| ||  ::.|.|.||||
Worm   499 FVMLKRRNPGEPELKGNDRFEGYCIDLLNLLAKNITGFEYDV-FISDGNKYG--SRQADGSWDGM 560

  Fly   552 VGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWIS 616
            :|.|:.:.||:|::.:|||.||||.:||||||||.|||||||||.||...:|||:.||...|||.
Worm   561 IGYLLNETADVAVAPLTITQERERAVDFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIF 625

  Fly   617 VILSYVGVSFVLYFVTRFPPYEWRI-VRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTM 680
            .:.||.|||..::.|:.|.|||.|| .:|.:...|                         ||||:
Worm   626 TLSSYFGVSLTIFLVSWFSPYEKRIEFKRGEFTVT-------------------------NEFTL 665

  Fly   681 LNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPED 745
            .||.|::||||||||.||.|.:::||||::.|||||:|::||||||||||||:|||..||::.||
Worm   666 YNSLWFTLAAFMQQGTDILPRAVSGRIASSCWWFFTLIIVSSYTANLAAFLTLERMTPPIESVED 730

  Fly   746 LTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-----------------NANQHHSVHTYD 793
            |..|..:.||....|||..||..|.:.|:.|||.:|                 :.:....|.:|.
Worm   731 LANQNKILYGVNEGGSTAAFFEDSIVPLYKKMWNFMVSTTQKQIELEKQSITNSTSNRIFVSSYA 795

  Fly   794 EGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLT 858
            :||.:||.||||||.|:|...|.|.:.|.||||||||:|::|.|:|:||.||:|||..||.|:|.
Worm   796 DGIEKVRTSKGKYAFLLEETTNNYESGRRPCDTMKVGQNLNTLGYGIATKIGNPLRVSLNLAILY 860

  Fly   859 LKENGELLRIRNKWWFDKTECNLDQETS---TPNELSLSNVAGIYYILIGGLLLAVIVAIMEF-F 919
            |.|.|||.::.||||:|:.:|  |..||   |.:.|:||.||||:|||:.|::|::..|::|| |
Worm   861 LSEKGELKKLENKWWYDRGQC--DTGTSDGGTSSSLNLSKVAGIFYILLAGMVLSMCTALVEFLF 923

  Fly   920 CRNKTPQLKSPGSNGSAGGV-PGMLAS 945
            .:||..:.|......|:..: ||:|||
Worm   924 RKNKENREKERNRMRSSRPLKPGILAS 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	107/469 (23%)
		ANF_receptor	53..434	CDD:279440	97/433 (22%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	199/431 (46%)
		Lig_chan	612..907	CDD:278489	144/315 (46%)
glr-2	NP_001021114.1	Periplasmic_Binding_Protein_Type_1	7..453	CDD:299141	107/468 (23%)
		Periplasmic_Binding_Protein_Type_2	491..875	CDD:304360	196/411 (48%)
		Lig_chan	621..910	CDD:278489	144/315 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	341	1.000	Domainoid score	I575
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37353
Inparanoid	1	1.050	556	1.000	Inparanoid score	I600
Isobase	1	0.950	-	0	Normalized mean entropy	S4333
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm4754
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.960