Protein Alignment GluRIA and glr-4

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001254126.1
• Gene: glr-4 / 174258
• WormBaseID: WBGene00001615
• Length: 951
• Species: Caenorhabditis elegans
• Alignment Length: 913
• Identity: 271/913 - (29%)
• Similarity: 433/913 - (47%)
• Gaps: 195/913 - (21%)

  Fly    62 LNHNLNVSSRRFEL--QAYVDVI-NTADAFKLSRLI---CNQFSRGVYSMLGAVSPDSFDTLHSY 120
            :.::.|...|..|:  |..|.|: :..::.:.|:||   |:.|:....|:......||..
 Worm    70 IRYDNNYEERMCEIMQQGIVAVVLSNEESEQDSQLIKSMCHYFNIPCLSLQSTSLRDSVS----- 129

  Fly   121 SNTFQMPFVTPWFPEKVLAPSSG-----LLDFAISMRPDYHQAIIDTIQYYGWQSIIYLY----D 176
                  .|||      :|.||.|     ..:|..|||               |...:..|    |
 Worm   130 ------DFVT------LLGPSRGAGARATSEFLDSMR---------------WTGFLLAYQHGSD 167

  Fly   177 SHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIE-FLHTLEDLGRFSKKRIVLDCPAEMAK 240
            ..| |..|.|..|.:..|.....:: ::|:.|.|...| ||..::.  |..:..|::........
 Worm   168 LED-LSPLMQYKQIVDTGGRRIHIK-IRRLPNNTDDYEPFLKYVKT--RLKQTNIIIHSNNITVL 228

  Fly   241 EIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVE--FGA---INITGFRIVDSNRRAVRDFHD 300
            ..::|..|.:.:....:.|:.:.  .|.....|.:.  :||   .||||.::|.::
 Worm   229 YNLLQQARGLNMAEPPFSYVFTN--TDLSLLEDFLNNMYGASFHCNITGLQLVKND--------- 282

  Fly   301 SRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHG 365
                                  |.:..|.||..:||:|:..:..|             ::...|
 Worm   283 ----------------------PMMKTQLALTSEAVYVVGMSIYR-------------MRELGH- 311

  Fly   366 GSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEI-DGLSGEIRFDEDGRRINYTL 429
                    ...:||.:.|.:..      |..|..::..:||::: :.|:|:::|..:|.|.:...
 Worm   312 --------APRQSSIMCDSHDI------WSDGRIMNEGIRKLKLRNQLTGDVQFKSNGERDDIMY 362

  Fly   430 HVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRN-------HTYIVSSLLE 487
            |.|. .:||...::..|.:..|        :...||.|:....|.|.:       |..:| ..||
 Worm   363 HGVG-RINSQFVKLGNWSEKRG--------WNFDSRYANRWEFDIDPDSEDLEGLHLRVV-VYLE 417

  Fly   488 EPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMV 552
            ||:: :|        .|.:::||:|.||.:.:...|...|.|..||||.||.|::  .|.|:|::
 Worm   418 EPFV-IK--------TGENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTYGIEDE--SGRWNGII 471

  Fly   553 GELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTP--GVFSFLNPLSQEIWI 615
            |.|.|.|||:::||:|||..|..|:||:.|||.|||||::.:..::|.  .:::||.|||..:||
 Worm   472 GALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILLARTSEETDKGSLWTFLEPLSLTVWI 536

  Fly   616 SVILSYVGVSFVLYFVTRFPPYEW----RIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPN 676
            |:::||..||:.::.:.:|.||||    ||..|...:...|:                      |
 Worm   537 SLLISYCIVSYSMHILAKFSPYEWYNLERIDERDFENIKNQK----------------------N 579

  Fly   677 EFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIK 741
            :||:|||||:::.:.||||.|:.|.:.|.|:.|.|||.||.|:||||||.||||||||||..||:
 Worm   580 QFTVLNSFWFTMGSLMQQGSDVIPRAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMSTPIE 644

  Fly   742 TPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVRQSKGK 805
            :.:||..|..:.||.|..|||.:|||.|:|.::.:||..|.::... .|::..|||.||:  .|.
 Worm   645 STQDLANQQKIRYGVLKSGSTMDFFRESKIPMYERMWSVMESSSPGVFVNSSREGIARVK--SGG 707

  Fly   806 YALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRN 870
            ||.::||...||...| .|:...:|..:|:||:|:|.|.|||||..|:..||.|:|...|..::|
 Worm   708 YAYMMESSMLEYYLER-DCELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKN 771

  Fly   871 KWWFDKTE---CNLDQETSTPNELSLS----NVAGIYYILIGGLLLAVIVAIMEFFC---RNKTP 925
            |||.|:.|   |.     ..|:|.:.:    |:.||:|:|:.||::|.::|..| :|   |::..
 Worm   772 KWWRDRREGPSCG-----PPPSEKATNSKPQNIFGIFYVLLTGLIVAFLLACGE-YCIESRHEAF 830

  Fly   926 QLK 928
            :||
 Worm   831 RLK 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	81/415 (20%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	168/418 (40%)
		Lig_chan	610..906	CDD:459656	122/307 (40%)
glr-4	NP_001254126.1	Periplasmic_Binding_Protein_type1	30..385	CDD:471960	81/420 (19%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:473866	164/401 (41%)