DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and glr-4

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	913	Identity:	271/913 - (29%)
Similarity:	433/913 - (47%)	Gaps:	195/913 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LNHNLNVSSRRFEL--QAYVDVI-NTADAFKLSRLI---CNQFSRGVYSMLGAVSPDSFDTLHSY 120
            :.::.|...|..|:  |..|.|: :..::.:.|:||   |:.|:....|:......||..
Worm    70 IRYDNNYEERMCEIMQQGIVAVVLSNEESEQDSQLIKSMCHYFNIPCLSLQSTSLRDSVS----- 129

  Fly   121 SNTFQMPFVTPWFPEKVLAPSSG-----LLDFAISMRPDYHQAIIDTIQYYGWQSIIYLY----D 176
                  .|||      :|.||.|     ..:|..|||               |...:..|    |
Worm   130 ------DFVT------LLGPSRGAGARATSEFLDSMR---------------WTGFLLAYQHGSD 167

  Fly   177 SHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIE-FLHTLEDLGRFSKKRIVLDCPAEMAK 240
            ..| |..|.|..|.:..|.....:: ::|:.|.|...| ||..::.  |..:..|::........
Worm   168 LED-LSPLMQYKQIVDTGGRRIHIK-IRRLPNNTDDYEPFLKYVKT--RLKQTNIIIHSNNITVL 228

  Fly   241 EIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVE--FGA---INITGFRIVDSNRRAVRDFHD 300
            ..::|..|.:.:....:.|:.:.  .|.....|.:.  :||   .||||.::|.::
Worm   229 YNLLQQARGLNMAEPPFSYVFTN--TDLSLLEDFLNNMYGASFHCNITGLQLVKND--------- 282

  Fly   301 SRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHG 365
                                  |.:..|.||..:||:|:..:..|             ::...|
Worm   283 ----------------------PMMKTQLALTSEAVYVVGMSIYR-------------MRELGH- 311

  Fly   366 GSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEI-DGLSGEIRFDEDGRRINYTL 429
                    ...:||.:.|.:..      |..|..::..:||::: :.|:|:::|..:|.|.:...
Worm   312 --------APRQSSIMCDSHDI------WSDGRIMNEGIRKLKLRNQLTGDVQFKSNGERDDIMY 362

  Fly   430 HVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRN-------HTYIVSSLLE 487
            |.|. .:||...::..|.:..|        :...||.|:....|.|.:       |..:| ..||
Worm   363 HGVG-RINSQFVKLGNWSEKRG--------WNFDSRYANRWEFDIDPDSEDLEGLHLRVV-VYLE 417

  Fly   488 EPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMV 552
            ||:: :|        .|.:::||:|.||.:.:...|...|.|..||||.||.|::  .|.|:|::
Worm   418 EPFV-IK--------TGENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTYGIEDE--SGRWNGII 471

  Fly   553 GELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTP--GVFSFLNPLSQEIWI 615
            |.|.|.|||:::||:|||..|..|:||:.|||.|||||::.:..::|.  .:::||.|||..:||
Worm   472 GALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILLARTSEETDKGSLWTFLEPLSLTVWI 536

  Fly   616 SVILSYVGVSFVLYFVTRFPPYEW----RIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPN 676
            |:::||..||:.::.:.:|.||||    ||..|...:...|:                      |
Worm   537 SLLISYCIVSYSMHILAKFSPYEWYNLERIDERDFENIKNQK----------------------N 579

  Fly   677 EFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIK 741
            :||:|||||:::.:.||||.|:.|.:.|.|:.|.|||.||.|:||||||.||||||||||..||:
Worm   580 QFTVLNSFWFTMGSLMQQGSDVIPRAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMSTPIE 644

  Fly   742 TPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVRQSKGK 805
            :.:||..|..:.||.|..|||.:|||.|:|.::.:||..|.::... .|::..|||.||:  .|.
Worm   645 STQDLANQQKIRYGVLKSGSTMDFFRESKIPMYERMWSVMESSSPGVFVNSSREGIARVK--SGG 707

  Fly   806 YALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRN 870
            ||.::||...||...| .|:...:|..:|:||:|:|.|.|||||..|:..||.|:|...|..::|
Worm   708 YAYMMESSMLEYYLER-DCELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKN 771

  Fly   871 KWWFDKTE---CNLDQETSTPNELSLS----NVAGIYYILIGGLLLAVIVAIMEFFC---RNKTP 925
            |||.|:.|   |.     ..|:|.:.:    |:.||:|:|:.||::|.::|..| :|   |::..
Worm   772 KWWRDRREGPSCG-----PPPSEKATNSKPQNIFGIFYVLLTGLIVAFLLACGE-YCIESRHEAF 830

  Fly   926 QLK 928
            :||
Worm   831 RLK 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	81/412 (20%)
		ANF_receptor	53..434	CDD:279440	77/393 (20%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	168/418 (40%)
		Lig_chan	612..907	CDD:278489	121/306 (40%)
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	81/420 (19%)
		ANF_receptor	45..365	CDD:279440	76/391 (19%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	164/401 (41%)
		Lig_chan	533..810	CDD:278489	121/306 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950