Protein Alignment GluRIA and nmr-1

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_495033.2
• Gene: nmr-1 / 173929
• WormBaseID: WBGene00003774
• Length: 1025
• Species: Caenorhabditis elegans
• Alignment Length: 945
• Identity: 210/945 - (22%)
• Similarity: 378/945 - (40%)
• Gaps: 215/945 - (22%)

  Fly    46 FEQGTDDVQSAFKYA-----------------MLNHNLN--------VSSRRFELQAYVDVINTA 85
            :..|.|.:.:||..|                 ||||:|.        .||.||     :|:: |:
 Worm    56 YHLGNDTISAAFVDAKSGDNRLELTQDIVCSQMLNHSLASVIFSPLLTSSSRF-----IDLV-TS 114

  Fly    86 DAFKLSRLICNQFSRGVYSM--LGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFA 148
            .|:.||          .|.:  :|.:..|:         .|....:.|.|    :.|::.|.|
 Worm   115 SAYTLS----------FYKLPVVGVMVRDA---------EFSKKNIYPTF----VRPTAPLSD-- 154

  Fly   149 ISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAI 213
                                ::.::|:    .||.|:  |:::.       |..|||..|....:
 Worm   155 --------------------EAFVFLH----MLLSLK--YRQVV-------VLSVKRDINADQFV 186

  Fly   214 EFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFG 278
            |         .|.|:|:..        :||||...:::|               |...:|.:...
 Worm   187 E---------EFEKRRVEF--------KIIVQRYIEVEL---------------NENLNDTLAES 219

  Fly   279 AINITGFRIVDSNRR--AVRDFHDSRKRLEPSGQSQ----SQNAGGPNSLPAIS-----AQAA-- 330
            ...:|...||...::  |||.|.::.   :.:|:.:    |::||..:::|..|     .|.|
 Worm   220 FEEVTSNIIVLFAKKDDAVRIFANAG---DLTGKGKVWIVSESAGEAHNVPNGSLGCRLGQTAFS 281

  Fly   331 LMYDAVFVLVEAFNRILRK-KPDQFRSNHLQRRSHGGSSSSSATGTNESSALLD--CNTSKGWVT 392
            ::.|:..:|..|...|.|: |.|.|......|     .|..:...:.::.|||:  |.||...|
 Worm   282 VLRDSFSILKSAMETIFRESKIDIFPPVECDR-----DSVDAEWNSLQAPALLNEICGTSTSRV- 340

  Fly   393 PWEQGEKISRV----------LRKVEIDGLSGEI-RFDEDGRRINYTLHVVEMSVNSTLQ--QVA 444
              ...:|..|:          :.:.::..:.|:| |.|||..........:|:|:...|:  .||
 Worm   341 --HFNDKCERIGVEYDIINFHMERKQVGNMVGDILRLDEDSIEWAGGTKPLEISLPKHLRVVTVA 403

  Fly   445 EWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFE 509
            :        |...:.....|.|..|..|     :|.:..|:.::..:|...|:...:|..:..:
 Worm   404 D--------PPFVYTTPIGSPSQCAELG-----NTVVEWSIFDKIVVSGPWYSCPLTLENSTEY- 454

  Fly   510 GYCKDLADMLAAQLGI---------KYEIRLVQDGNYGAENQYAPGG--WDGMVGELIRKEADIA 563
            ..|..||..|.:.|.:         .:...|..:.:||........|  ..|::|||....||:|
 Worm   455 FCCAGLAIDLLSNLSLPEANNSIDTSFTFSLHLNESYGVVQASETTGITISGVIGELDGDTADMA 519

  Fly   564 ISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVL 628
            |..:||..||||::||::|::..||.|:.|...:.:| :.|||.||...:|.::.:|.:.|...:
 Worm   520 IGGITINPERERIVDFTEPWLYHGIRILEKNIPRDSP-MQSFLQPLQSSLWTALFISVILVGLAI 583

  Fly   629 YFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQ 693
            |.:....|:|    |..|||...:|.       ...|.:..:............:.|:.....:.
 Worm   584 YCLDFKSPFE----RFYQADKEMEQD-------LKKEFELWIGKDADENVNFGEAMWFVWGVLLN 637

  Fly   694 QG-CDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTV---ERMVAPIKTPEDLTMQTDVNY 754
            .| .:.||.|.:.|:...||..|.:|:::||||||||||.:   |:.:..:..|.......:.::
 Worm   638 SGVSEKTPRSCSARVLGIVWCGFCMIMVASYTANLAAFLVLDQPEKGLTGVTDPRLRNPSANFSF 702

  Fly   755 GTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVN 819
            ||:|..:.:::|:|     |.::.......:.|:|....|.:..:... ...|.:.:|.:.|:..
 Worm   703 GTVLNSNVYQYFKR-----HVELSSMFRKMEPHNVRRASEAVHSLLNG-SLDAFIWDSTRLEFEA 761

  Fly   820 ARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDK--TECNLD 882
            || .|:....|.......:|:.....||....:..|:|.:.|:|.:.::..| |.|:  ..|.::
 Worm   762 AR-HCELRTRGSLFGRSAYGIGLQKNSPWTPHITSAILRMSESGVMEKLDQK-WIDRGGPNCVVE 824

  Fly   883 QETSTPNELSLSNVAGIYYILIGGLLLAVIVAIME 917
            ...| |..|.|.|:..|:.::..|:.|.:.::.:|
 Worm   825 AHKS-PARLGLVNMKDIFILVSSGVALGIFLSFVE 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	95/465 (20%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	101/418 (24%)
		Lig_chan	610..906	CDD:459656	67/301 (22%)
nmr-1	NP_495033.2	Periplasmic_Binding_Protein_type1	19..384	CDD:471960	89/434 (21%)
		PBP2_iGluR_NMDA_Nr1	394..822	CDD:270437	109/461 (24%)
		Lig_chan	566..844	CDD:459656	67/297 (23%)
		LITAF	949..1017	CDD:197841