Protein Alignment GluRIA and glr-3

DIOPT Version :9

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_492017.3
• Gene: glr-3 / 172449
• WormBaseID: WBGene00001614
• Length: 836
• Species: Caenorhabditis elegans
• Alignment Length: 889
• Identity: 257/889 - (28%)
• Similarity: 406/889 - (45%)
• Gaps: 178/889 - (20%)

  Fly    86 DAFKLSRLICNQFSRGVYS-----MLGA---VSPDSFD-------TLHSYSNTFQMPFVTPWFPE 135
            ::||:..:   ....|::|     :|||   :.|:.:|       .:.|.::...:|.|:
 Worm    59 ESFKIVGI---SIENGLFSVCNCLILGASAIILPEQYDGHLAAAAIVQSIADNTNVPCVS----- 115

  Fly   136 KVLAPSSGLLDFAISMRPDYH---------QAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQEL 191
                     |..:...||..|         .|:...|:...|:.::.:::..|.||.:..:....
 Worm   116 ---------LHLSPPTRPSTHLHPHLNAKSLAVAAFIKREKWKDVVVVFEEPDELLEITDMITAG 171

  Fly   192 KPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRT 256
            ....::|..|:|:.........|..|....|.|:   |||::.|.:.|...:.| ..::.:....
 Worm   172 HFDPDSFSSQLVRLKHGDDYGNELKHIKNKLDRY---RIVINIPLQKALHFLEQ-AANMSMCGVL 232

  Fly   257 YHYLLSGLVMDNHWPSDV--VEFGAI------NITGFRIVDSNRRAVRDF-----HDSRKRLEPS 308
            |||    :|||    .|:  |:..:|      |||.|.:.|.|...:.|.     |.|..||...
 Worm   233 YHY----VVMD----MDLVTVDIDSIRGIEDCNITSFGVHDVNSEYIEDIRQEIVHKSSIRLPKK 289

  Fly   309 GQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSAT 373
            |               :....::..|.:.:|:.:           .:|..:......|||
 Worm   290 G---------------VPYTTSIWIDTLRLLIRS-----------MKSIQIWDEPRCGSS----- 323

  Fly   374 GTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNS 438
                                |:.|..|.:...:..:.|:||::.:...|.|.||||||...::
 Worm   324 --------------------WKSGSDIKKRFFENPLAGISGDLHWAPSGERSNYTLHVYRRTL-- 366

  Fly   439 TLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGD---YDRNHTYIVSSLLEEPYLSLKQYTYGE 500
            :.|:.|||..       .:...|||.....|::.:   .:..|..| |..||.|::
 Worm   367 SFQKFAEWSS-------RTRRIASSEAVVIANSSEKLTLEGKHLKI-SVYLEAPFV--------- 414

  Fly   501 SLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAIS 565
            .:..|..:||||.||...:|..|...|.|:.|:|..||::.  :.|.|.||||||.|.:||:|::
 Worm   415 MITSNGSYEGYCIDLLHKIANILKFTYTIQKVRDNAYGSKE--SNGKWSGMVGELQRGDADLAVA 477

  Fly   566 AMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYF 630
            ::||:..|..||||:.|:|.|||||:.|||..:....|.|::|||.::||....||..||..::.
 Worm   478 SLTISYGRSEVIDFTVPYMHLGISILFKKPRIRDSDWFKFMDPLSTQVWIMTFASYFVVSVAIWI 542

  Fly   631 VTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQG 695
            :.:..|||       |.:.              .|......|| .|:|::.||||:::.:.||||
 Worm   543 IAKISPYE-------QFER--------------DEDNGQYKPV-DNQFSLRNSFWFTVCSLMQQG 585

  Fly   696 CDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYG 760
            .::.|.:.:.|:...:||||.:||||||||||||.||..||..||:..:||..||.:.||||..|
 Worm   586 SELCPRAASTRLLTGIWWFFALILISSYTANLAAVLTTRRMETPIENADDLAAQTKIKYGTLGRG 650

  Fly   761 STWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCD 825
            ||..||..|:|..:.:||:.|:::....|.:..|||.||:.|  .||.|:||...||...| .|:
 Worm   651 STMSFFNESKIETYERMWQLMSSSPGLFVQSSKEGIARVKSS--DYAYLMESSMLEYAVER-DCE 712

  Fly   826 TMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKT-EC----NLDQET 885
            .|::|..||.||:|:..|.|||.|:.::.|:|.|:|..||..::.|||.||: .|    ..||:.
 Worm   713 LMQIGGLIDQKGYGIGLPKGSPYRELISTAILRLQEKTELTELKEKWWKDKSVVCEQPKRKDQDD 777

  Fly   886 STPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNKTPQLKS 929
            .       .::.||:.||:.||:|..::.|.|.....|....:|
 Worm   778 G-------ESIGGIFIILVVGLVLTAVLVIFELITTRKPSPAQS 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	80/403 (20%)
		ANF_receptor	53..434	CDD:279440	76/384 (20%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	159/402 (40%)
		Lig_chan	612..907	CDD:278489	111/299 (37%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591	82/414 (20%)
		Periplasmic_Binding_Protein_Type_2	401..761	CDD:419667	156/396 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840