DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GluRIA and Grin3b

DIOPT Version :9

Sequence 1:NP_476855.1 Gene:GluRIA / 38742 FlyBaseID:FBgn0004619 Length:991 Species:Drosophila melanogaster
Sequence 2:NP_579842.2 Gene:Grin3b / 170796 RGDID:621705 Length:1002 Species:Rattus norvegicus


Alignment Length:1006 Identity:207/1006 - (20%)
Similarity:351/1006 - (34%) Gaps:346/1006 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 LNHNLNVSSRRFELQAYVDVINTADAFKLSRLICN-----------------------QF----- 98
            |.|||::     ||.|...  .|.|...|:|.:|.                       ||     
  Rat    66 LPHNLSL-----ELVAVAS--PTRDPASLARGLCQVLAPPGVVASIAFPEARPELRLLQFLAAAT 123

  Fly    99 --------SRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDY 155
                    .|.|.:.|||.:|            |.:..  .|     .:|...:||..:|:    
  Rat   124 ETPVVSVLRREVRTALGAPTP------------FHLQL--DW-----ASPLETILDVLVSL---- 165

  Fly   156 HQAIIDTIQYYGWQ-------------SIIYLYDSHDG--------LLRLQQIYQELKPGNETFR 199
                   ::.:.|:             |::.|:.:|..        |.||......|:.|     
  Rat   166 -------VRAHAWEDIALVLCRVRDPGSLVTLWTNHASQAPKFVLDLSRLDSRNDSLRAG----- 218

  Fly   200 VQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGL 264
                         :..|..||..|......::|.|....|                  |.:|...
  Rat   219 -------------LALLGALEGGGTPVPAAVLLGCSTARA------------------HEVLEAA 252

  Fly   265 VMDNHW------PSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPS----GQSQSQNAGGP 319
            .....|      |::     |:..||                    |.|.    |:::.      
  Rat   253 PPGPQWLLGTPLPAE-----ALPTTG--------------------LPPGVLALGETEQ------ 286

  Fly   320 NSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALL-- 382
            :||.|:      ::|.|.::.:|.:.:....|::                          |||  
  Rat   287 HSLEAV------VHDMVELVAQALSSMALVHPER--------------------------ALLPA 319

  Fly   383 -----DCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVN----- 437
                 |..|.....|    |..::|.|......|.:|.: :.....:::.:.|....|:.     
  Rat   320 VVNCDDLKTGGSEAT----GRTLARFLGNTSFQGRTGAV-WVTGSSQVHVSRHFKVWSLRRDPLG 379

  Fly   438 -STLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTY-GE 500
             .....|..|:|  |.|.....  |::.|..|.| |...|....:| :|:|.|::..::... |:
  Rat   380 APAWATVGSWQD--GQLDFQPG--AAALRV
PSPS-GTQARPKLRVV-TLVEHPFVFTRESDEDGQ 438

  Fly   501 SLVG--------ND--RFE--------------------GYCKDLADMLAAQLGIKYEIRLVQDG 535
            ...|        ||  |.:                    |||.||.:.||..|...:|:.:|.||
  Rat   439 CPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDG 503

  Fly   536 NYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTP 600
            .|||   ...|.|.|:||:|:...|.:|:::.:|.:.|.:|:||:.||.:..:.||::.....:|
  Rat   504 KYGA---LRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASP 565

  Fly   601 GVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSE 665
             :.:|:.||...:|:.|   :..:.....|:|.   ||||            .|.|:        
  Rat   566 -IGAFMWPLHWSMWVGV---FAALHLTALFLTL---YEWR------------SPYGL-------- 603

  Fly   666 PQAHVPPVPPNEFTMLNSFWYSLA-------AFMQQGCDITPPSIAGRIAAAVWWFFTIILISSY 723
                 .|...|..|:   |.||.|       .|.:.....||....||....:|..|.::::|||
  Rat   604 -----TPRGRNRGTV---FSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSY 660

  Fly   724 TANLAAFLTVERMVAPIKTPEDLTMQTD---------VNYGTLLYGSTWEFFRRSQIGLHNKMWE 779
            ||||||.:..:      ||.|:|:...|         ..:||:...|...:.:.|...:|..|  
  Rat   661 TANLAAVMVGD------KTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHM-- 717

  Fly   780 YMNANQHHSVHTYDEGIRRVRQSKGKY-ALLVESPKNEY-VNARPPCDTMKVGRNIDTKGFGVAT 842
                 :.||..|...|:..:.....|. |.:::....:| |:....|..:.||:....:|:|:..
  Rat   718 -----RRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGL 777

  Fly   843 PIGSPLRKRLNEAVLTLKENGELLRIRNKWW---------FDKTECNLDQETSTPNELSLSNVAG 898
            |..|||...|:|.:...|.:|.:..:.:||:         |..||         ..::.:.:.:|
  Rat   778 PQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTE---------TLQMGVYHFSG 833

  Fly   899 IYYILIGGLLLAVIVAIME-FFCRNKTPQLK 928
            ::.:|..||..|::.::.| .|.|...|:::
  Rat   834 LFVLLCLGLGSALLTSLGEHVFYRLVLPRIR 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIANP_476855.1 PBP1_iGluR_AMPA 41..453 CDD:107375 76/470 (16%)
ANF_receptor 53..434 CDD:279440 71/445 (16%)
PBP2_iGluR_AMPA 477..879 CDD:270433 114/459 (25%)
Lig_chan 612..907 CDD:278489 72/321 (22%)
Grin3bNP_579842.2 PBP1_iGluR_NMDA_NR3 21..405 CDD:107372 78/483 (16%)
PBP2_iGluR_NMDA_Nr3 414..808 CDD:270438 112/445 (25%)
Lig_chan 576..842 CDD:278489 72/321 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 882..910
Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250 951..984
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166349649
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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