DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grin3b

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_006513350.1	Gene:	Grin3b / 170483	MGIID:	2150393	Length:	1138	Species:	Mus musculus

Alignment Length:	1020	Identity:	217/1020 - (21%)
Similarity:	362/1020 - (35%)	Gaps:	339/1020 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LNHNLNVSSRRFELQAYVDVINTADAFKLSRLICN-----------------------QF----- 98
            |.|||::     ||.|...  .|.|...|:|.:|.                       ||
Mouse   146 LPHNLSL-----ELVAVAS--PTRDPASLARGLCQVLAPPGVVASITFPEARPELRLLQFLAAAT 203

  Fly    99 --------SRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDY 155
                    .|.|.:.|||.:|            |.:..  .|     .:|...:||..:|:
Mouse   204 ETPVLSVLRREVRAPLGAPTP------------FHLQL--DW-----ASPLETILDVLVSL---- 245

  Fly   156 HQAIIDTIQYYGWQSI-------------IYLYDSHDG-----LLRLQQIYQELKPGNETFRVQM 202
                   ::.:.|:.|             :.|:.|...     :|.|.|    |..||::.|
Mouse   246 -------VRAHAWEDIALVLCRVRDPSGLVTLWTSRASQAPKFVLDLSQ----LDSGNDSLR--- 296

  Fly   203 VKRIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMD 267
                  .|:|:  |.|||..|......::|.|....|                  |.:|......
Mouse   297 ------ATLAL--LGTLEGGGTPVSAAVLLGCSTAHA------------------HEVLEAAPPG 335

  Fly   268 NHW------PSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAIS 326
            ..|      |::     |:..||.                     |.|.......|.|      |
Mouse   336 PQWLLGTPLPAE-----ALPKTGL---------------------PPGVLVLGETGQP------S 368

  Fly   327 AQAALMYDAVFVLVEAFNRILRKKPDQF---RSNHLQRRSHGGSSSSSATGTNESSALLDCNTSK 388
            .:|| ::|.|.::..|.:.:....|::.   .:.:.:....|||.|::.|
Mouse   369 LEAA-VHDMVELVARALSSMALMHPERALLPAAVNCEDLKTGGSESTART--------------- 417

  Fly   389 GWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVN------STLQQVAEWR 447
                       ::|.|......|.:|.: :.....:::.:.|....|:.      .....|..|:
Mouse   418 -----------LARFLSNTSFQGRTGAV-WVAGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQ 470

  Fly   448 DDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTY-GESLVG------- 504
            |  |.|.....  |::.|..|.| |...|....:| :|:|.|::..::... |:...|
Mouse   471 D--GQLDFQPG--AAALRVPSPS-GTQARPKLRVV-TLVEHPFVFTRESDEDGQCPAGQLCLDPG 529

  Fly   505 -ND--RFE--------------------GYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPG 546
             ||  |.:                    |||.||.:.||..|...:|:.:|.||.|||   ...|
Mouse   530 TNDSARLDALFTALENGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGA---LRDG 591

  Fly   547 GWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQ 611
            .|.|:||:|:...|.:|:::.:|.:.|.:|:||:.||.:..:.||::.....:| :.:|:.||..
Mouse   592 RWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASP-IGAFMWPLHW 655

  Fly   612 EIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPN 676
            .:|:.|   :..:.....|:|.   ||||            .|.|:             .|...|
Mouse   656 SMWVGV---FAALHLTALFLTL---YEWR------------SPYGL-------------TPRGRN 689

  Fly   677 EFTMLNSFWYSLA-------AFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVE 734
            ..|:   |.||.|       .|.:.....||....||....:|..|.::::|||||||||.:..:
Mouse   690 RGTV---FSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGD 751

  Fly   735 RMVAPIKTPEDLTMQTD---------VNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVH 790
                  ||.|:|:...|         ..:||:...|...:.:.|...:|..|       :.||..
Mouse   752 ------KTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHM-------RRHSAP 803

  Fly   791 TYDEGIRRVRQSKGKY-ALLVESPKNEY-VNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLN 853
            |...|:..:.....|. |.:::....:| |:....|..:.||:....:|:|:..|..|||...|:
Mouse   804 TTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLS 868

  Fly   854 EAVLTLKENGELLRIRNKWW---------FDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLL 909
            |.:...|.:|.:..:.:||:         |..||         ..::.:.:::|::.:|..||..
Mouse   869 EFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTE---------TLQMGVYHLSGLFVLLCLGLGS 924

  Fly   910 AVIVAIME-FFCR---------NK------TPQLKSPGSNGSAGG 938
            |::.::.| .|.|         ||      |.|::.....|..||
Mouse   925 ALLTSLGEHVFYRLVLPRIRRGNKLQYWLHTSQVRRQDKVGRGGG 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	80/459 (17%)
		ANF_receptor	53..434	CDD:279440	75/434 (17%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	114/459 (25%)
		Lig_chan	612..907	CDD:278489	72/321 (22%)
Grin3b	XP_006513350.1	PBP1_iGluR_NMDA_NR3	141..481	CDD:380600	81/468 (17%)
		PBP2_iGluR_NMDA_Nr3	494..888	CDD:270438	112/445 (25%)
		Lig_chan	656..922	CDD:365843	72/321 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846186
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740