Protein Alignment GluRIA and gria3a

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_073805840.1
• Gene: gria3a / 170452
• ZFINID: ZDB-GENE-020125-5
• Length: 940
• Species: Danio rerio
• Alignment Length: 982
• Identity: 385/982 - (39%)
• Similarity: 549/982 - (55%)
• Gaps: 135/982 - (13%)

  Fly    31 QQTVSLTEKIPLGAIFEQGTDDVQSAFKYA--MLNHNLNVSSRRFELQAYVDVINTADAFKLSRL 93
            |.......:|.:|.:|.:.|....|||::|  :.|.|.|::.:.|.|...||.:.::::|.::..
Zfish    18 QTQAGFPNQINIGGLFMRSTVQEHSAFRFAVQLYNTNQNITEKPFHLNYNVDNLESSNSFSVTHA 82

  Fly    94 ICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQA 158
            .|:|||||||::.|.....|.:||.|:.......|:||.|      |:...:.|.:.|||....|
Zfish    83 FCSQFSRGVYAIFGFYDRRSMNTLTSFCGALHTSFITPSF------PTDTDVQFVLQMRPSLRGA 141

  Fly   159 IIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLG 223
            ::..:.:|.|:..:||||:..|...||.|.:.....|  ::| ..:.:.|:...:|:...:|::.
Zfish   142 LLSLLAHYKWEKFVYLYDTDRGFSILQAIMESAVMNN--WQV-TARSVGNIVDPLEYRRIIEEMD 203

  Fly   224 RFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIV 288
            |..:||.::||..|....|:.|.|...| ..|.|||:|:.|...| ...|.|..|..|||||:|:
Zfish   204 RRQEKRFLIDCEVERINSILEQVVIAGK-NSRGYHYILANLGFTN-MSLDKVFSGGANITGFQII 266

  Fly   289 DSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQ 353
            :.:...|:.|....:||:.....:|:::       .:...:||.:||:.|:.|||..:.|::.|
Zfish   267 NPDSPIVQQFLQRWERLDEREFPESRSS-------PLKYTSALTHDAILVIAEAFRYLRRQRVD- 323

  Fly   354 FRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRF 418
                 :.||...|                ||..:.  ..||.||..|.|.|:.|::.|::|.|:|
Zfish   324 -----ISRRGSAG----------------DCLANP--AVPWSQGIDIERALKMVQVQGMTGNIQF 365

  Fly   419 DEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVS 483
            |..|||.|||:.|.||..... :::..|.:....:.:......:.|.|.        .|.|.:|:
Zfish   366 DSFGRRSNYTVDVYEMKPGGA-RKIGYWNEFEKFVYIVEQQVTNESSSV--------ENRTIVVT 421

  Fly   484 SLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGW 548
            :::|.||:..|: .|.: |.||||:||||.|||..:|..:||||::.:|.||.|||.:.... .|
Zfish   422 TIMEAPYVMYKR-NYMQ-LEGNDRYEGYCVDLASEIAKHVGIKYKLSIVADGKYGARDPETK-TW 483

  Fly   549 DGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEI 613
            :||||||:...||||::.:|||..||.|||||||||:||||||||||.|..|||||||:||:.||
Zfish   484 NGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEI 548

  Fly   614 WISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEF 678
            |:.::.:|:|||.||:.|:||.||||.:      |...:          ..:||  .||.|||:|
Zfish   549 WMCIVFAYIGVSVVLFLVSRFSPYEWHL------DDNEE----------TKDPQ--TPPDPPNDF 595

  Fly   679 TMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTP 743
            .:.||.|:||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||:||::.
Zfish   596 GIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESA 660

  Fly   744 EDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYA 807
            |||..||::.||||..|||.||||||:|.::.|||.|| :|.....|.|..:|:.|||:||||:|
Zfish   661 EDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFVKTTPDGVARVRKSKGKFA 725

  Fly   808 LLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKW 872
            .|:||..|||:..|.||||||||.|:|:||:|||||.||.||..:|.|||.|.|.|.|.:::|||
Zfish   726 FLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRSAVNLAVLKLNEQGLLDKLKNKW 790

  Fly   873 WFDKTECN--------------------------------------LDQ----------ETSTPN 889
            |:||.||.                                      ||:          |..|.:
Zfish   791 WYDKGECGSGGGDSKHKARCPTVSLWLTDIRTPVNLAVLKLSEQGILDKLKNKWWYDKGECGTKD 855

  Fly   890 E--------LSLSNVAGIYYILIGGLLLAVIVAIMEFFCRN--KTPQLKSPGSNGSAGGVPGMLA 944
            .        ||||||||::|||:|||.||:.||::||..::  :|.:||...:..:....|...|
Zfish   856 SGSKDKTSALSLSNVAGVFYILVGGLGLAMTVALVEFCYKSHQETKRLKLAKNAQNFKPAPPSTA 920

  Fly   945 SS--TYQ 949
            .|  ||:
Zfish   921 QSFTTYR 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	122/416 (29%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	225/402 (56%)
		Lig_chan	610..906	CDD:459656	166/352 (47%)
gria3a	XP_073805840.1	None