Protein Alignment GluRIA and gria2a

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_005170953.1
• Gene: gria2a / 170450
• ZFINID: ZDB-GENE-020125-3
• Length: 893
• Species: Danio rerio
• Alignment Length: 979
• Identity: 388/979 - (39%)
• Similarity: 556/979 - (56%)
• Gaps: 160/979 - (16%)

  Fly    40 IPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYS 104
            :.:|.:|.:|.|...|||:..|    :...:..|.|..::|.:..|::|.::...|:|||||||:
Zfish    22 VQIGGLFPRGADQEYSAFRIGM----VQFGTAEFRLTPHIDNLEVANSFAITNCFCSQFSRGVYA 82

  Fly   105 MLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQ 169
            :.|.....|.:|:.|:..|..:.|:||.|      |:.||..|.:.||||....:|..::||.|:
Zfish    83 IFGFYDKKSVNTITSFCETLHVSFITPSF------PADGLNQFVLQMRPDIKGPLISLVEYYKWE 141

  Fly   170 SIIYLYDSHDGLLRLQQIYQ----------ELKPGN-------ETFRVQMVKRIANVTMAIEFLH 217
            ...|||||..||..||.:..          .:..||       |.:|                 .
Zfish   142 KFAYLYDSDRGLSTLQAVLDTAAERKWQVTAINVGNLKDEWKDEAYR-----------------S 189

  Fly   218 TLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGR--RTYHYLLS--GLVMDNHWPSDV--VE 276
            ..:||...:::|::|||..:..|:|:.|   .|.:||  :.|||:::  |.|     ..|:  ::
Zfish   190 LFQDLENKNERRVILDCEQDKVKDIMEQ---VITIGRHVKGYHYIIANFGFV-----DGDLSKIQ 246

  Fly   277 FGAINITGFRIVDSNRRAVRDFHDSRKRLE----PSGQSQSQNAGGPNSLPAISAQAALMYDAVF 337
            :|..|::||:|||.:...|..|....:.||    |...|:            |...:||.||||.
Zfish   247 YGGANVSGFQIVDFDDPLVAKFDQRWEALEEKEYPGADSR------------IRYTSALTYDAVQ 299

  Fly   338 VLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISR 402
            |:.|||..:.:::.|      :.||.:.|                ||..:.  ..||.||.:|.|
Zfish   300 VMTEAFRFLHKQRID------ISRRGNNG----------------DCLANP--AVPWAQGVEIER 340

  Fly   403 VLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSA 467
            .|::|.:|||:|.|:||:.|||:|||::|:|:. ||...::..|.:...:....|..:.:.:...
Zfish   341 ALKQVRVDGLTGNIQFDQYGRRVNYTVNVMELK-NSGPVKIGYWNEMDKMAVTKSDLFPNDTMGM 404

  Fly   468 SASTGDYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLV 532
                    .|.|.||:::||.||:.||:  ..|....|:|:||||.|||..:|...|.||::|:|
Zfish   405 --------ENKTVIVTTILEAPYVMLKK--NAELFTDNERYEGYCVDLAAEIAKHCGFKYQLRIV 459

  Fly   533 QDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVK 597
            .||.|||.:.... .|:||||||:..:||||::.:|||..||.|||||||||:||||||||||.|
Zfish   460 ADGKYGARDAETK-IWNGMVGELVYGKADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQK 523

  Fly   598 QTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGAT 662
            ..|||||||:||:.|||:.::.:|:|||.||:.|:||.||||.         |.:...|.:|
Zfish   524 SKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH---------TEEFEDGQLG--- 576

  Fly   663 LSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANL 727
                    |....|||.:.||.|:||.|||||||||:|.|::|||...||||||:|:||||||||
Zfish   577 --------PSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 633

  Fly   728 AAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHT 791
            ||||||||||:||::.|||..||::.||||..|||.||||||:|.|.:|||:|| :|.....|..
Zfish   634 AAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFRRSKIALFDKMWQYMKSAEPSVFVKN 698

  Fly   792 YDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAV 856
            ..||:.|||:||||||.|:||..|||:..|.||||||||.|:|:||:|:|||.||.||..:|.||
Zfish   699 TVEGVLRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNAVNLAV 763

  Fly   857 LTLKENGELLRIRNKWWFDKTEC-----NLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIM 916
            |.|.|.|.|.:::||||:||.||     ...::||.   ||||||||::|||:|||.||::||::
Zfish   764 LKLNEQGLLDKLKNKWWYDKGECGSGGGESKEKTSA---LSLSNVAGVFYILVGGLGLAMLVALV 825

  Fly   917 EFFCRNKTPQLKSPGSNGSAGGVPGMLASSTYQRDSLSDAIMHSQAKLAMQASSEYDERLVGVEL 981
            ||..:::                    |.:...:.:.:|| |.|:|:|::..|:..:.|::..:.
Zfish   826 EFCYKSR--------------------AEAKRMKMTFTDA-MRSKARLSITGSTGENGRVLTPDF 869

  Fly   982 ASNV 985
            :..|
Zfish   870 SKAV 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	129/441 (29%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	224/402 (56%)
		Lig_chan	610..906	CDD:459656	163/301 (54%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_type1	23..393	CDD:471960	129/441 (29%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	222/399 (56%)