DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grin2d

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_036008580.1	Gene:	Grin2d / 14814	MGIID:	95823	Length:	1345	Species:	Mus musculus

Alignment Length:	665	Identity:	154/665 - (23%)
Similarity:	267/665 - (40%)	Gaps:	136/665 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 PSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRK---KPDQFRSNHLQRRSHGGSS 368
            |:|....::||..:.|      |..:...|.|:......:||.   .|:.......|.|:|
Mouse   303 PAGLFAVRSAGWRDDL------ARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTH---- 357

  Fly   369 SSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVE 433
                                       :||.:.|....:..|  :.:..|:|||..:|.:|.|:.
Mouse   358 ---------------------------RGESLHRYFMNITWD--NRDYSFNEDGFLVNPSLVVIS 393

  Fly   434 MSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLK---- 494
            ::.:.|.:.|..|......|     .|...||.........|..| ..|::|.|.|::.::
Mouse   394 LTRDRTWEVVGSWEQQTLRL-----KYPLWSRYGRFLQPVDDTQH-LTVATLEERPFVIVEPADP 452

  Fly   495 --------------QYTYGESLVG------------NDRFEGYCKDLADMLAAQLGIKYEIRLVQ 533
                          |.....|||.            ....:|:|.|:...||..:|..|::.||.
Mouse   453 ISGTCIRDSVPCRSQLNRTHSLVAPRSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVT 517

  Fly   534 DGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQ 598
            :|.:|.:   ..|.|:||:||:..:.||:||.::||..||..::|||.||:..|||:|:.:. ..
Mouse   518 NGKHGKK---IDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARS-NG 578

  Fly   599 TPGVFSFL-----------NPLSQEIWISVILSYVGVSFVLYFVTRF-PPYEWRIVRRPQADSTA 651
            |....:||           .|.|..:|:.:.:..:.|..|..|:..: .|..:.     ::.:|.
Mouse   579 TVSPSAFLAFAWLMPPMSPEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYN-----RSLATG 638

  Fly   652 QQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFF 715
            ::|    ||:|               ||:..|.|...|........: .|.....:|...||.||
Mouse   639 KRP----GGST---------------FTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFF 684

  Fly   716 TIILISSYTANLAAFLTVERMVAPIKTPEDLTMQ------TDVNYGTLLYGSTWEFFRRSQIGLH 774
            .:|.::|||||||||:..|..|..:....|...|      ..:.:||:..|||.:..|.:...:|
Mouse   685 AVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMH 749

  Fly   775 NKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCD--TMKVGRNIDTKG 837
            :.|..|   ||..    .:|.:.:::..|....:...:..|........|.  |:..|:...|.|
Mouse   750 SYMVRY---NQPR----VEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTG 807

  Fly   838 FGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYI 902
            :|:|...||..::.::.|:|....:.|:..:...|.  ...|:.|:.....::|.:.|:||::|:
Mouse   808 YGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL--SGICHNDKIEVMSSKLDIDNMAGVFYM 870

  Fly   903 LIGGLLLAVIVAIME 917
            |:..:.|:::|...|
Mouse   871 LLVAMGLSLLVFAWE 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	28/148 (19%)
		ANF_receptor	53..434	CDD:279440	25/129 (19%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	110/452 (24%)
		Lig_chan	612..907	CDD:278489	70/304 (23%)
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:415822	29/155 (19%)
Grin2d	XP_036008580.1	PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	111/454 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810