DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GluRIA and Grin2c

DIOPT Version :9

Sequence 1:NP_476855.1 Gene:GluRIA / 38742 FlyBaseID:FBgn0004619 Length:991 Species:Drosophila melanogaster
Sequence 2:XP_017169765.1 Gene:Grin2c / 14813 MGIID:95822 Length:1307 Species:Mus musculus


Alignment Length:1000 Identity:213/1000 - (21%)
Similarity:363/1000 - (36%) Gaps:264/1000 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 ELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDT------LHSYSNTFQMPF---- 128
            |:|.....:|..:...:...||...  |...:.|.|..|:.||      |...|:...:|.    
Mouse   123 EIQPLTIGVNNTNPSSILTQICGLL--GAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSIS 185

  Fly   129 ------VTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDG---LLR- 183
                  :||      ..|.|..|...:|:.... |.:...::.|.|.:...:...|.|   .|. 
Mouse   186 GGSAVVLTP------KEPGSAFLQLGVSLEQQL-QVLFKVLEEYDWSAFAVITSLHPGHALFLEG 243

  Fly   184 --------------LQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDC 234
                          |..:..||.||....|.|.:.|..:..:.:.:                  |
Mouse   244 VRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAPVLVAY------------------C 290

  Fly   235 PAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNH-WPSDVVEFGAINITGFRIVDSNRRAVRDF 298
            ..|.|:.:..:..:             :|||...| |                            
Mouse   291 SREEAEVLFAEAAQ-------------AGLVGPGHVW---------------------------- 314

  Fly   299 HDSRKRLEPS---GQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSN--- 357
                  |.|:   |.:.:..|..|..|             :.|:.|::...||:|   .|..   
Mouse   315 ------LVPNLALGSTDAPPAAFPVGL-------------ISVVTESWRLSLRQK---VRDGVAI 357

  Fly   358 -----HLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIR 417
                 |..||.:|...:.:.          ||.:..|.|:|  ..|...|.|..|..:|  .:..
Mouse   358 LALGAHSYRRQYGTLPAPAG----------DCRSHPGPVSP--AREAFYRHLLNVTWEG--RDFS 408

  Fly   418 FDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIV 482
            |...|..:..|:.|:.::.:...:.|..|  |.|:|.:   .|....|.:::.....|..| ..|
Mouse   409 FSPGGYLVQPTMVVIALNRHRLWEMVGRW--DHGVLYM---KY
PVWPRYSTSLQPVVDSRH-LTV 467

  Fly   483 SSLLEEPYLSLKQYTYGES----------LVGNDRF-------------EGYCKDLADMLAAQLG 524
            ::|.|.|::.::....|..          ...|..|             :|:|.|:...||..:.
Mouse   468 ATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDITPYTKLCCKGFCIDILKKLAKVVK 532

  Fly   525 IKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGIS 589
            ..|::.||.:|.:|   :...|.|:||:||:..|.||:||.::||..||..:||||.||:..|||
Mouse   533 FSYDLYLVTNGKHG---KRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGIS 594

  Fly   590 IMIKKPVKQTPGVFSFLNPLSQEIWISV-ILSYVGVSFVLYFVTRFPP--YEWRIVRRPQADSTA 651
            :|:.:. ..|....:||.|.|..:|:.: ::....|:..::....|.|  |...:.:..::    
Mouse   595 VMVARS-NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKS---- 654

  Fly   652 QQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFF 715
                   ||.:               ||:..|.|...|........| .|.....:|...||.||
Mouse   655 -------GGPS---------------FTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFF 697

  Fly   716 TIILISSYTANLAAFLTVERMVAPIKTPEDLTMQ------TDVNYGTLLYGSTWEFFRRSQIGLH 774
            .:|.::|||||||||:..|:.:..:....|...|      ....:||:..|||....|.:...:|
Mouse   698 AVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMH 762

  Fly   775 NKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPP-CD--TMKVGRNIDTK 836
            ..|.::...:...::.:...|.|.|  |:...|.:.::....|:..:.. |.  |:..|:...|.
Mouse   763 THMVKFNQRSVEDALTSLKMGARHV--SRKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATT 825

  Fly   837 GFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYY 901
            |:|:|....|..::.::.|:|....:||..::...|.  ...|:.::.....::|.:.|:||::|
Mouse   826 GYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL--SGICHNEKNEVMSSKLDIDNMAGVFY 888

  Fly   902 ILIGGLLLAVIVAIME---------------------------FFCRNKTPQLKSPG-------S 932
            :|:..:.||::|...|                           :.|.|....|.||.       :
Mouse   889 MLLVAMGLALLVFAWEHLVYWKLRHSVPSSSQLDFLLAFSRGIYSCFNGVQSLPSPARPPSPDLT 953

  Fly   933 NGSA-GGVPGMLASSTYQRDSLSDA 956
            .||| ..|..||.::   ||.:|.|
Mouse   954 AGSAQANVLKMLQAA---RDMVSTA 975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIANP_476855.1 PBP1_iGluR_AMPA 41..453 CDD:107375 76/424 (18%)
ANF_receptor 53..434 CDD:279440 72/405 (18%)
PBP2_iGluR_AMPA 477..879 CDD:270433 107/437 (24%)
Lig_chan 612..907 CDD:278489 66/307 (21%)
Grin2cXP_017169765.1 PBP1_iGluR_NMDA_NR2 90..446 CDD:380601 77/431 (18%)
PBP2_iGluR_NMDA_Nr2 462..868 CDD:270436 108/440 (25%)
NMDAR2_C 905..>980 CDD:371139 14/73 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846188
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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