Protein Alignment GluRIA and Grin2c

DIOPT Version :10

• Sequence 1: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_017169765.1
• Gene: Grin2c / 14813
• MGIID: 95822
• Length: 1307
• Species: Mus musculus
• Alignment Length: 1000
• Identity: 213/1000 - (21%)
• Similarity: 363/1000 - (36%)
• Gaps: 264/1000 - (26%)

  Fly    74 ELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDT------LHSYSNTFQMPF---- 128
            |:|.....:|..:...:...||...  |...:.|.|..|:.||      |...|:...:|.
Mouse   123 EIQPLTIGVNNTNPSSILTQICGLL--GAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSIS 185

  Fly   129 ------VTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQSIIYLYDSHDG---LLR- 183
                  :||      ..|.|..|...:|:.... |.:...::.|.|.:...:...|.|   .|.
Mouse   186 GGSAVVLTP------KEPGSAFLQLGVSLEQQL-QVLFKVLEEYDWSAFAVITSLHPGHALFLEG 243

  Fly   184 --------------LQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDC 234
                          |..:..||.||....|.|.:.|..:..:.:.:                  |
Mouse   244 VRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAPVLVAY------------------C 290

  Fly   235 PAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNH-WPSDVVEFGAINITGFRIVDSNRRAVRDF 298
            ..|.|:.:..:..:             :|||...| |
Mouse   291 SREEAEVLFAEAAQ-------------AGLVGPGHVW---------------------------- 314

  Fly   299 HDSRKRLEPS---GQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSN--- 357
                  |.|:   |.:.:..|..|..|             :.|:.|::...||:|   .|..
Mouse   315 ------LVPNLALGSTDAPPAAFPVGL-------------ISVVTESWRLSLRQK---VRDGVAI 357

  Fly   358 -----HLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIR 417
                 |..||.:|...:.:.          ||.:..|.|:|  ..|...|.|..|..:|  .:..
Mouse   358 LALGAHSYRRQYGTLPAPAG----------DCRSHPGPVSP--AREAFYRHLLNVTWEG--RDFS 408

  Fly   418 FDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIV 482
            |...|..:..|:.|:.::.:...:.|..|  |.|:|.:   .|....|.:::.....|..| ..|
Mouse   409 FSPGGYLVQPTMVVIALNRHRLWEMVGRW--DHGVLYM---KYPVWPRYSTSLQPVVDSRH-LTV 467

  Fly   483 SSLLEEPYLSLKQYTYGES----------LVGNDRF-------------EGYCKDLADMLAAQLG 524
            ::|.|.|::.::....|..          ...|..|             :|:|.|:...||..:.
Mouse   468 ATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDITPYTKLCCKGFCIDILKKLAKVVK 532

  Fly   525 IKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGIS 589
            ..|::.||.:|.:|   :...|.|:||:||:..|.||:||.::||..||..:||||.||:..|||
Mouse   533 FSYDLYLVTNGKHG---KRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGIS 594

  Fly   590 IMIKKPVKQTPGVFSFLNPLSQEIWISV-ILSYVGVSFVLYFVTRFPP--YEWRIVRRPQADSTA 651
            :|:.:. ..|....:||.|.|..:|:.: ::....|:..::....|.|  |...:.:..::
Mouse   595 VMVARS-NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKS---- 654

  Fly   652 QQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFF 715
                   ||.:               ||:..|.|...|........| .|.....:|...||.||
Mouse   655 -------GGPS---------------FTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFF 697

  Fly   716 TIILISSYTANLAAFLTVERMVAPIKTPEDLTMQ------TDVNYGTLLYGSTWEFFRRSQIGLH 774
            .:|.::|||||||||:..|:.:..:....|...|      ....:||:..|||....|.:...:|
Mouse   698 AVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMH 762

  Fly   775 NKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPP-CD--TMKVGRNIDTK 836
            ..|.::...:...::.:...|.|.|  |:...|.:.::....|:..:.. |.  |:..|:...|.
Mouse   763 THMVKFNQRSVEDALTSLKMGARHV--SRKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATT 825

  Fly   837 GFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYY 901
            |:|:|....|..::.::.|:|....:||..::...|.  ...|:.::.....::|.:.|:||::|
Mouse   826 GYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL--SGICHNEKNEVMSSKLDIDNMAGVFY 888

  Fly   902 ILIGGLLLAVIVAIME---------------------------FFCRNKTPQLKSPG-------S 932
            :|:..:.||::|...|                           :.|.|....|.||.       :
Mouse   889 MLLVAMGLALLVFAWEHLVYWKLRHSVPSSSQLDFLLAFSRGIYSCFNGVQSLPSPARPPSPDLT 953

  Fly   933 NGSA-GGVPGMLASSTYQRDSLSDA 956
            .||| ..|..||.::   ||.:|.|
Mouse   954 AGSAQANVLKMLQAA---RDMVSTA 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	77/427 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	107/437 (24%)
		Lig_chan	610..906	CDD:459656	67/308 (22%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	77/431 (18%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	108/440 (25%)
		NMDAR2_C	905..>980	CDD:463148	14/73 (19%)