DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grin2b

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_001350679.1	Gene:	Grin2b / 14812	MGIID:	95821	Length:	1482	Species:	Mus musculus

Alignment Length:	1009	Identity:	217/1009 - (21%)
Similarity:	388/1009 - (38%)	Gaps:	230/1009 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CASSIFW-------PEFSSAQQQQQTVSLTEKIPLG-AIFEQGTDDVQSAFKYAMLN---HNLNV 68
            |.|..||       ...|.|:.|:...|      :| |:...||.| :.|.|.|...   |:|:|
Mouse     7 CCSPKFWLVLAVLAVSGSKARSQKSAPS------IGIAVILVGTSD-EVAIKDAHEKDDFHHLSV 64

  Fly    69 SSRRFELQAYVDVINTADAFKLSRLICNQFS-RGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPW 132
            .. |.||.|    :|..|...:...||:..| |.:..::.|...|. :.:....:......:||.
Mouse    65 VP-RVELVA----MNETDPKSIITRICDLMSDRKIQGVVFADDTDQ-EAIAQILDFISAQTLTPI 123

  Fly   133 F-----PEKVLA---PSSGLLDFAISMRPDYHQA--IIDTIQYYGWQSIIYLYDSHDGLLRLQQI 187
            .     ...::|   .||....|..|:.   .||  :::.::.|.|    |::          .|
Mouse   124 LGIHGGSSMIMADKDESSMFFQFGPSIE---QQASVMLNIMEEYDW----YIF----------SI 171

  Fly   188 YQELKPGNETFRVQMVKRIANVTMAIEFLHTL--------------EDLGRFSKKRIVLDCPAEM 238
            .....||.:.|..::...|.|..:..|....|              ..|.:.....|:|.|..|.
Mouse   172 VTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEE 236

  Fly   239 AKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRK 303
            | ..|.:....:.|....|.:::..||
Mouse   237 A-TYIFEVANSVGLTGYGYTWIVPSLV-------------------------------------- 262

  Fly   304 RLEPSGQSQSQNAGGPNSLPAIS------AQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRR 362
                :|.:.:..:..|..|.::|      ...|.:.|.:.::..|            .|:.|...
Mouse   263 ----AGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIAIITTA------------ASDMLSEH 311

  Fly   363 SHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINY 427
            |......||...|:|....              |...::|.|..|..:|.:  :.|.|||.:::.
Mouse   312 SFIPEPKSSCYNTHEKRIY--------------QSNMLNRYLINVTFEGRN--LSFSEDGYQMHP 360

  Fly   428 TLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLS 492
            .|.::.::.....::|.:|:|.:    |....|...  .....|.:.:.:|..|| :|.|.|::.
Mouse   361 KLVIILLNKERKWERVGKWKDKS----LQMKYYVWP--RMCPETEEQEDDHLSIV-TLEEAPFVI 418

  Fly   493 LKQ------------YTYGESLVGNDRFE-----------GYCKDLADMLAAQLGIKYEIRLVQD 534
            ::.            ....:.::..::.:           |:|.|:...::..:...|::.||.:
Mouse   419 VESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN 483

  Fly   535 GNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQT 599
            |.:|.:   ..|.|:||:||::.|.|.:|:.::||..||..|:|||.||:..|||:|:.:. ..|
Mouse   484 GKHGKK---INGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRS-NGT 544

  Fly   600 PGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTR-FPPYEWRIVRRPQADSTAQQPPGIIGGATL 663
            ....:||.|.|.::|:.:.:..:.||.|..||.. |.|..:   .|..||  .::|.|
Mouse   545 VSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY---NRCLAD--GREPGG------- 597

  Fly   664 SEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTANL 727
                       |: ||:..:.|............: .|.....:|..:||.||.:|.::||||||
Mouse   598 -----------PS-FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANL 650

  Fly   728 AAFLTVERMVAPIKTPEDLTMQ------TDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQH 786
            |||:..|..|..:....|...|      ....:||:..|||....|.:...:|..|.::   ||
Mouse   651 AAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKF---NQ- 711

  Fly   787 HSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPP-CD--TMKVGRNIDTKGFGVATPIGSPL 848
               ...|:.:..::..| ..|.:.::....|:..|.. |.  |:..|:...:.|:|:|....|..
Mouse   712 ---RGVDDALLSLKTGK-LDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGW 772

  Fly   849 RKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIV 913
            :::::.|:|.|..:||:..:...|.  ...|:.::.....::|.:.|:||::|:|...:.|::|.
Mouse   773 KRQVDLAILQLFGDGEMEELEALWL--TGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLIT 835

  Fly   914 AIME--FFCRNKTPQLKSPGSNGSAGGVPGMLAS 945
            .|.|  |:.:.:...:      |...|.|||:.|
Mouse   836 FICEHLFYWQFRHCFM------GVCSGKPGMVFS 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	81/446 (18%)
		ANF_receptor	53..434	CDD:279440	73/414 (18%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	107/435 (25%)
		Lig_chan	612..907	CDD:278489	72/305 (24%)
Grin2b	NP_001350679.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	83/459 (18%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	108/438 (25%)
		NMDAR2_C	840..1482	CDD:402274	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846174
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840