DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grin2a

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_032196.2	Gene:	Grin2a / 14811	MGIID:	95820	Length:	1464	Species:	Mus musculus

Alignment Length:	1005	Identity:	214/1005 - (21%)
Similarity:	372/1005 - (37%)	Gaps:	270/1005 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 AIFEQGTDDVQSAFKYAMLNHNLNVSSRRFE----------LQAYVDVI----NTADAFKLSRLI 94
            |..|:||..:..|   .:|.|:.:|:.|...          |...|:|:    |..|...|...:
Mouse    25 AAAEKGTPALNIA---VLLGHSHDVTERELRNLWGPEQATGLPLDVNVVALLMNRTDPKSLITHV 86

  Fly    95 CNQFS---------------RGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLA---PS 141
            |:..|               ..|..||..:|..:|..:........|          ::|   |:
Mouse    87 CDLMSGARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASM----------IMADKDPT 141

  Fly   142 SGLLDFAISMRPDYHQA--IIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVK 204
            |....|..|::   .||  ::..:|.|.|              .:..:...:.||...| :..:|
Mouse   142 STFFQFGASIQ---QQATVMLKIMQDYDW--------------HVFSLVTTIFPGYRDF-ISFIK 188

  Fly   205 -------------RIANVTMAIEFLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRT 256
                         .:..:..:.|...|...|.:.....|:|.|..:.| .:|:...|.:.|....
Mouse   189 TTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEA-VLILSEARSLGLTGYD 252

  Fly   257 YHYLLSGLVMDN------HWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQN 315
            :.:::..||..|      .:||     |.|:::              :.|....||
Mouse   253 FFWIVPSLVSGNTELIPKEFPS-----GLISVS--------------YDDWDYSLE--------- 289

  Fly   316 AGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSA 380
                          |.:.|.:.:|..|            .|:.|::.|:...:.:|..|..|...
Mouse   290 --------------ARVRDGLGILTTA------------ASSMLEKFSYIPEAKASCYGQTEKPE 328

  Fly   381 LLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAE 445
                       ||.   ..:.:.:..|..||  .::.|.|:|.:::..|.|:.::.:...::|.:
Mouse   329 -----------TPL---HTLHQFMVNVTWDG--KDLSFTEEGYQVHPRLVVIVLNKDREWEKVGK 377

  Fly   446 WRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQY-TYGESLVGND--- 506
            |.:..     .|..:|...|..|.|..:.|.||..|| :|.|.|::.::.. ...|:.|.|.
Mouse   378 WENQT-----LSLRHAVWPRYKSFSDCEPDDNHLSIV-TLEEAPFVIVEDIDPLTETCVRNTVPC 436

  Fly   507 -RF-----------------EGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVG 553
             :|                 :|:|.|:...|:..:...|::.||.:|.:|.:   ....|:||:|
Mouse   437 RKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKK---VNNVWNGMIG 498

  Fly   554 ELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVI 618
            |::.:.|.:|:.::||..||..|:|||.||:..|||:|:.:. ..|....:||.|.|..:|:.:.
Mouse   499 EVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS-NGTVSPSAFLEPFSASVWVMMF 562

  Fly   619 LSYVGVSFVLYFVTR-FPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLN 682
            :..:.||.:..||.. |.|..:   .|..|...|...|                     .||:..
Mouse   563 VMLLIVSAIAVFVFEYFSPVGY---NRNLAKGKAPHGP---------------------SFTIGK 603

  Fly   683 SFWYSLAAFMQQGCDI-TPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDL 746
            :.|............: .|.....:|..:||.||.:|.::|||||||||:..|..|..:....|.
Mouse   604 AIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDK 668

  Fly   747 TMQTDVNY------GTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHH------SVHT-------Y 792
            ..|...:|      ||:..|||....|.:...:|..|.::   ||..      |:.|       |
Mouse   669 KFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKF---NQRGVEDALVSLKTGKLDAFIY 730

  Fly   793 DEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVL 857
            |..:...:..:.:...||               |:..|....|.|:|:|...|||.:::::.|:|
Mouse   731 DAAVLNYKAGRDEGCKLV---------------TIGSGYIFATTGYGIALQKGSPWKRQIDLALL 780

  Fly   858 TLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF---- 918
            ....:||:..:...|.  ...|:.::.....::|.:.|:||::|:|...:.|::|..|.|.
Mouse   781 QFVGDGEMEELETLWL--TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYW 843

  Fly   919 ---FCRNKTPQLKSPGSNGSAGGVPGMLAS 945
               ||           ..|.....||:|.|
Mouse   844 KLRFC-----------FTGVCSDRPGLLFS 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	79/461 (17%)
		ANF_receptor	53..434	CDD:279440	73/433 (17%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	111/444 (25%)
		Lig_chan	612..907	CDD:278489	72/315 (23%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	77/466 (17%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	112/447 (25%)
		HisJ	<458..>541	CDD:223904	30/86 (35%)
		Lig_chan	556..828	CDD:278489	72/315 (23%)
		NMDAR2_C	839..1464	CDD:287527	7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910