DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIA and Grik5

DIOPT Version :9

Sequence 1:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_030098003.1	Gene:	Grik5 / 14809	MGIID:	95818	Length:	1003	Species:	Mus musculus

Alignment Length:	938	Identity:	301/938 - (32%)
Similarity:	469/938 - (50%)	Gaps:	165/938 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FEQGTDDVQSAFKYAMLNHNLNVSSR---------RFELQAYVDVINTA----DAFKLSR----- 92
            |...:..|.|:.:.|.:..:..|..|         |.::...::|...|    |.|:|.|
Mouse    13 FANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYE 77

  Fly    93 ---LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFA-ISMR 152
               .:|....:||.|:|| :.||.|..|:.......::|.:... ||:  .|....|.|| :|:.
Mouse    78 TTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG-PEE--TPRLQYLRFASVSLY 139

  Fly   153 P---DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIE 214
            |   |...|:...::.:.:.|...:....:.||||:::.:......||..|:|:....:.|
Mouse   140 PSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPT---- 200

  Fly   215 FLHTLEDLGRFSKKRIVLDCPAEMAKEII----------------------VQHVRDIKLGRRTY 257
              ..|:::.......|::|..|.::..::                      |....::.:....|
Mouse   201 --PLLKEIRDDKVSTIIIDANASISHLVLRLSLNLSSPLGFPRSLPLGLSCVLQASELGMTSAFY 263

  Fly   258 HYLLS----------GLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQ 312
            .|:|:          |:|.|:.           ||.||.:.:::.....:|..|   |..|.:..
Mouse   264 KYILTTMDFPILHLDGIVEDSS-----------NILGFSMFNTSHPFYPEFVRS---LNMSWREN 314

  Fly   313 SQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNE 377
            .:.:..|.  ||:|  ||||:|||.|:|.|.             ..|.|....|....:.|..|
Mouse   315 CEASTYPG--PALS--AALMFDAVHVVVSAV-------------RELNRSQEIGVKPLACTSAN- 361

  Fly   378 SSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQ 442
                           .|..|..:...||.||.|||:|.:.|:..|:|.||||.::|.| ....::
Mouse   362 ---------------IWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKS-RQGHRE 410

  Fly   443 VAEWRDDAGLLPLHSHNYASSSRSASASTGDYD-----RNHTYIVSSLLEEPYLSLKQYTYGESL 502
            :..|             |::.:.:.:|:|.|.:     .|.|.:|:::||.||: :::..: ::|
Mouse   411 IGVW-------------YSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYV-MRRPNF-QAL 460

  Fly   503 VGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELI-RKEADIAISA 566
            .||:||||:|.|:...||..|..:|.:|||:||.|||..  ..|.|.||||||| |::||:|::|
Mouse   461 SGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPE--PNGSWTGMVGELINRQKADLAVAA 523

  Fly   567 MTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFV 631
            .|||||||:|||||||||||||||:.:..:.:.||.||||:|.|..:|:.::|:|:.||.||:..
Mouse   524 FTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLA 588

  Fly   632 TRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGC 696
            .|..||||   ..|.....|:                  |.:..|::|:.||.|:.:..|||||.
Mouse   589 ARLSPYEW---YNPHPCLRAR------------------PHILENQYTLGNSLWFPVGGFMQQGS 632

  Fly   697 DITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGS 761
            :|.|.:::.|..:.|||.||:|:||||||||||||||:||..|:::.:||..||::.|||:..||
Mouse   633 EIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGS 697

  Fly   762 TWEFFRRSQIGLHNKMWEYMNANQHH-SVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCD 825
            |..||:.|:...:.:||.||.:.|.. .|.:.:|||.||..|  :||.|:||..||| :.|..|:
Mouse   698 TMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCN 759

  Fly   826 TMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNE 890
            ..::|..:||||:|:..|:|||.|..:..|:|.|:||..|..::.||| :...|. .:|......
Mouse   760 LTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWW-EGGRCP-KEEDHRAKG 822

  Fly   891 LSLSNVAGIYYILIGGLLLAVIVAIMEF 918
            |.:.|:.||:.:||.||::||.||:|||
Mouse   823 LGMENIGGIFVVLICGLIIAVFVAVMEF 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	102/464 (22%)
		ANF_receptor	53..434	CDD:279440	98/438 (22%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	178/403 (44%)
		Lig_chan	612..907	CDD:278489	114/295 (39%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	100/470 (21%)
Grik5	XP_030098003.1	Periplasmic_Binding_Protein_Type_2	437..808	CDD:419667	178/399 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846194
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.680